Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | ABC transporter transmembrane region family protein | 0.003 | 0.1053 | 0.102 |
Schistosoma mansoni | multidrug resistance protein | 0.003 | 0.1053 | 0.5 |
Entamoeba histolytica | ATP-binding cassette protein, putative | 0.003 | 0.1053 | 0.5 |
Echinococcus granulosus | multidrug resistance associated protein 7 | 0.003 | 0.1053 | 1 |
Schistosoma mansoni | multidrug resistance protein | 0.003 | 0.1053 | 0.5 |
Echinococcus multilocularis | multidrug resistance associated protein 1 | 0.003 | 0.1053 | 1 |
Entamoeba histolytica | ATP-binding cassette protein, putative | 0.003 | 0.1053 | 0.5 |
Trypanosoma cruzi | multidrug resistance protein E, putative | 0.003 | 0.1053 | 1 |
Leishmania major | ATP-binding cassette protein subfamily C, member 6, putative | 0.003 | 0.1053 | 0.5 |
Echinococcus multilocularis | multidrug resistance associated protein 7 | 0.003 | 0.1053 | 1 |
Echinococcus granulosus | multidrug resistance associated protein 1 | 0.003 | 0.1053 | 1 |
Leishmania major | p-glycoprotein e | 0.003 | 0.1053 | 0.5 |
Loa Loa (eye worm) | inward rectifying k channel family protein 1 | 0.009 | 1 | 1 |
Schistosoma mansoni | multidrug resistance protein | 0.003 | 0.1053 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.009 | 1 | 1 |
Schistosoma mansoni | multidrug resistance protein | 0.003 | 0.1053 | 0.5 |
Trypanosoma brucei | multidrug resistance protein E | 0.003 | 0.1053 | 0.5 |
Entamoeba histolytica | ABC transporter, putative | 0.003 | 0.1053 | 0.5 |
Toxoplasma gondii | hypothetical protein | 0.009 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.009 | 1 | 1 |
Entamoeba histolytica | multidrug resistance protein, putative | 0.003 | 0.1053 | 0.5 |
Brugia malayi | ABC transporter transmembrane region family protein | 0.003 | 0.1053 | 0.5 |
Leishmania major | ATP-binding cassette protein subfamily C, member 1, putative | 0.003 | 0.1053 | 0.5 |
Trypanosoma brucei | multidrug resistance-associated protein, putative | 0.003 | 0.1053 | 0.5 |
Entamoeba histolytica | ATP-binding cassette protein, putative | 0.003 | 0.1053 | 0.5 |
Giardia lamblia | Multidrug resistance-associated protein 1 | 0.003 | 0.1053 | 1 |
Giardia lamblia | MRP-like ABC transporter | 0.003 | 0.1053 | 1 |
Leishmania major | ATP-binding cassette protein subfamily C, member 2, putative | 0.003 | 0.1053 | 0.5 |
Giardia lamblia | Multidrug resistance-associated protein 1 | 0.003 | 0.1053 | 1 |
Entamoeba histolytica | ATP-binding cassette protein, putative | 0.003 | 0.1053 | 0.5 |
Leishmania major | ATP-binding cassette protein subfamily C, member 5, putative | 0.003 | 0.1053 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.003 | 0.1053 | 0.102 |
Leishmania major | pentamidine resistance protein 1 | 0.003 | 0.1053 | 0.5 |
Trypanosoma cruzi | multidrug resistance-associated protein, putative | 0.003 | 0.1053 | 1 |
Giardia lamblia | ABC transporter, putative | 0.003 | 0.1053 | 1 |
Trypanosoma cruzi | multidrug resistance-associated protein, putative | 0.003 | 0.1053 | 1 |
Trypanosoma brucei | p-glycoprotein | 0.003 | 0.1053 | 0.5 |
Brugia malayi | multidrug resistance related protein 1 | 0.003 | 0.1053 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.003 | 0.1053 | 0.102 |
Loa Loa (eye worm) | hypothetical protein | 0.003 | 0.1016 | 0.0983 |
Trypanosoma brucei | multidrug resistance-associated protein, putative | 0.003 | 0.1053 | 0.5 |
Entamoeba histolytica | hypothetical protein | 0.003 | 0.1053 | 0.5 |
Leishmania major | ABC-thiol transporter | 0.003 | 0.1053 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (functional) | = 8 | In vivo antiviral protection againstlethal Forest virus (SFV) infection at dosage of 200 mg/kg tested in 12 mice | ChEMBL. | 8230133 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.