Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | protein tyrosine phosphatase, non-receptor type 1 | Starlite/ChEMBL | References |
Homo sapiens | protein tyrosine phosphatase, non-receptor type 11 | Starlite/ChEMBL | References |
Homo sapiens | protein tyrosine phosphatase, receptor type, A | Starlite/ChEMBL | References |
Homo sapiens | protein tyrosine phosphatase, non-receptor type 2 | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Schistosoma mansoni | protein tyrosine phosphatase | protein tyrosine phosphatase, non-receptor type 2 | 410 aa | 335 aa | 25.7 % |
Echinococcus granulosus | receptor type tyrosine protein phosphatase zeta | protein tyrosine phosphatase, receptor type, A | 802 aa | 657 aa | 31.2 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | protein-tyrosine phosphatase | 0.0452 | 0.6129 | 1 |
Echinococcus granulosus | tyrosine protein phosphatase non receptor type | 0.0452 | 0.6129 | 0.6129 |
Schistosoma mansoni | protein tyrosine phosphatase non-receptor type nt1 | 0.0452 | 0.6129 | 1 |
Echinococcus multilocularis | tyrosine protein phosphatase non receptor type | 0.0452 | 0.6129 | 0.6129 |
Brugia malayi | Protein-tyrosine phosphatase containing protein | 0.0452 | 0.6129 | 1 |
Echinococcus multilocularis | receptor type tyrosine protein phosphatase protein tyrosine phosphatase receptor type | 0.0627 | 1 | 1 |
Echinococcus granulosus | receptor type tyrosine protein phosphatase | 0.0627 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 2.4 nM | Inhibition of PTP1B (unknown origin) | LITERATURE. | 27526040 |
IC50 (binding) | = 10 uM | Inhibition of human recombinant SHP2 | ChEMBL. | 18680359 |
Ki (binding) | = 2.4 nM | Inhibitory activity against protein-tyrosine phosphatase 1B (PTP 1B) was determined | ChEMBL. | 12877578 |
Ki (binding) | = 2.4 nM | Inhibitory activity against Protein-tyrosine phosphatase 1B | ChEMBL. | 15293983 |
Ki (binding) | = 2.4 nM | Inhibition of PTP1B expressed in human HepG2 cells | ChEMBL. | 17249650 |
Ki (binding) | = 2.4 nM | Inhibitory activity against protein-tyrosine phosphatase 1B (PTP 1B) was determined | ChEMBL. | 12877578 |
Ki (binding) | = 2.4 nM | Inhibitory activity against Protein-tyrosine phosphatase 1B | ChEMBL. | 15293983 |
Ki (binding) | = 2.4 nM | Inhibition of PTP1B expressed in human HepG2 cells | ChEMBL. | 17249650 |
Ki (binding) | = 2.4 nM | Inhibition of PTP1B | ChEMBL. | 20153651 |
Ki (binding) | = 2.4 nM | Inhibition of PTP1B | ChEMBL. | 21420867 |
Ki (binding) | = 24 nM | Inhibitory constant against T cell protein tyrosine phosphatase | ChEMBL. | 12877578 |
Ki (binding) | = 24 nM | Inhibitory constant against T cell protein tyrosine phosphatase | ChEMBL. | 12877578 |
Ki (binding) | = 24 nM | Inhibition of TCPTP | ChEMBL. | 20153651 |
Ki (binding) | = 0.0024 uM | Inhibition of PTP1B | ChEMBL. | 20000419 |
Ki (binding) | = 0.026 uM | Inhibition of TCPTP | ChEMBL. | 20000419 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
8 literature references were collected for this gene.