Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium tuberculosis | NAD(P)H quinone reductase LpdA | 0.0118 | 0.125 | 1 |
Plasmodium vivax | SET domain protein, putative | 0.0029 | 0.0182 | 0.4358 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0029 | 0.0182 | 0.1126 |
Schistosoma mansoni | histone-lysine n-methyltransferase suv9 | 0.0029 | 0.0182 | 0.1126 |
Echinococcus multilocularis | thioredoxin glutathione reductase | 0.0047 | 0.0389 | 0.3729 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.006 | 0.0548 | 0.3391 |
Onchocerca volvulus | 0.0233 | 0.2639 | 1 | |
Echinococcus granulosus | thioredoxin glutathione reductase | 0.0047 | 0.0389 | 0.3729 |
Loa Loa (eye worm) | hypothetical protein | 0.0845 | 1 | 1 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.006 | 0.0548 | 1 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.006 | 0.0548 | 1 |
Brugia malayi | Pre-SET motif family protein | 0.0029 | 0.0182 | 0.016 |
Plasmodium vivax | glutathione reductase, putative | 0.0047 | 0.0389 | 1 |
Schistosoma mansoni | alpha-galactosidase/alpha-n-acetylgalactosaminidase | 0.0101 | 0.1043 | 0.6451 |
Wolbachia endosymbiont of Brugia malayi | dihydrolipoamide dehydrogenase E3 component | 0.0016 | 0.0022 | 0.5 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.006 | 0.0548 | 1 |
Schistosoma mansoni | alpha-galactosidase/alpha-n-acetylgalactosaminidase | 0.0101 | 0.1043 | 0.6451 |
Toxoplasma gondii | melibiase subfamily protein | 0.0101 | 0.1043 | 1 |
Echinococcus multilocularis | histone lysine N methyltransferase SETMAR | 0.0029 | 0.0182 | 0.1746 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0029 | 0.0182 | 0.1126 |
Schistosoma mansoni | alpha-galactosidase/alpha-n-acetylgalactosaminidase | 0.0101 | 0.1043 | 0.6451 |
Loa Loa (eye worm) | glutathione reductase | 0.0047 | 0.0389 | 0.0389 |
Mycobacterium tuberculosis | Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras | 0.0118 | 0.125 | 1 |
Plasmodium falciparum | glutathione reductase | 0.0047 | 0.0389 | 1 |
Mycobacterium tuberculosis | Probable reductase | 0.0106 | 0.1107 | 0.8837 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.006 | 0.0548 | 0.3391 |
Schistosoma mansoni | dihydrolipoamide dehydrogenase | 0.0016 | 0.0022 | 0.0138 |
Toxoplasma gondii | thioredoxin reductase | 0.0047 | 0.0389 | 0.3591 |
Giardia lamblia | NADH oxidase lateral transfer candidate | 0.0016 | 0.0022 | 0.5 |
Schistosoma mansoni | alpha-galactosidase/alpha-n-acetylgalactosaminidase | 0.0067 | 0.0638 | 0.3948 |
Mycobacterium leprae | DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE | 0.0118 | 0.125 | 1 |
Echinococcus multilocularis | histone lysine methyltransferase setb histone lysine methyltransferase eggless | 0.0029 | 0.0182 | 0.1746 |
Schistosoma mansoni | alpha-galactosidase/alpha-n-acetylgalactosaminidase | 0.0067 | 0.0638 | 0.3948 |
Toxoplasma gondii | histone lysine methyltransferase SET/SUV39 | 0.0029 | 0.0182 | 0.1565 |
Trichomonas vaginalis | alpha-galactosidase/alpha-N-acetylgalactosaminidase, putative | 0.0067 | 0.0638 | 0.2355 |
Chlamydia trachomatis | dihydrolipoyl dehydrogenase | 0.0016 | 0.0022 | 0.5 |
Mycobacterium tuberculosis | Probable dehydrogenase | 0.0106 | 0.1107 | 0.8837 |
Echinococcus multilocularis | Alpha N acetylgalactosaminidase | 0.0101 | 0.1043 | 1 |
Plasmodium falciparum | thioredoxin reductase | 0.0047 | 0.0389 | 1 |
Brugia malayi | hypothetical protein | 0.012 | 0.1272 | 0.1252 |
Mycobacterium tuberculosis | Probable NADH dehydrogenase Ndh | 0.0106 | 0.1107 | 0.8837 |
Mycobacterium tuberculosis | Probable membrane NADH dehydrogenase NdhA | 0.0106 | 0.1107 | 0.8837 |
Echinococcus granulosus | nuclear factor of activated T cells 5 | 0.0073 | 0.0701 | 0.6726 |
Loa Loa (eye worm) | pre-SET domain-containing protein family protein | 0.0205 | 0.2296 | 0.2296 |
Leishmania major | trypanothione reductase | 0.0047 | 0.0389 | 0.697 |
Loa Loa (eye worm) | hypothetical protein | 0.0845 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0029 | 0.0182 | 0.0182 |
Loa Loa (eye worm) | hypothetical protein | 0.0313 | 0.359 | 0.359 |
Treponema pallidum | NADH oxidase | 0.0016 | 0.0022 | 0.5 |
Trypanosoma cruzi | trypanothione reductase, putative | 0.0047 | 0.0389 | 1 |
Echinococcus granulosus | histone lysine methyltransferase setb | 0.0029 | 0.0182 | 0.1746 |
Brugia malayi | Melibiase family protein | 0.0067 | 0.0638 | 0.0617 |
Loa Loa (eye worm) | NNMT/PNMT/TEMT family protein | 0.0845 | 1 | 1 |
Leishmania major | aldehyde dehydrogenase, mitochondrial precursor | 0.006 | 0.0548 | 1 |
Echinococcus granulosus | Alpha N acetylgalactosaminidase | 0.0101 | 0.1043 | 1 |
Echinococcus granulosus | aldehyde dehydrogenase mitochondrial | 0.006 | 0.0548 | 0.5257 |
Echinococcus multilocularis | dihydrolipoamide dehydrogenase | 0.0016 | 0.0022 | 0.0215 |
Brugia malayi | glutathione reductase | 0.0047 | 0.0389 | 0.0367 |
Trichomonas vaginalis | set domain proteins, putative | 0.0233 | 0.2637 | 1 |
Toxoplasma gondii | aldehyde dehydrogenase | 0.006 | 0.0548 | 0.5153 |
Echinococcus multilocularis | aldehyde dehydrogenase, mitochondrial | 0.006 | 0.0548 | 0.5257 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0029 | 0.0182 | 0.1126 |
Echinococcus multilocularis | nuclear factor of activated T cells 5 | 0.0073 | 0.0701 | 0.6726 |
Mycobacterium tuberculosis | Probable oxidoreductase | 0.0118 | 0.125 | 1 |
Mycobacterium tuberculosis | Putative ferredoxin reductase | 0.0106 | 0.1107 | 0.8837 |
Echinococcus granulosus | dihydrolipoamide dehydrogenase | 0.0016 | 0.0022 | 0.0215 |
Schistosoma mansoni | alpha-galactosidase/alpha-n-acetylgalactosaminidase | 0.0101 | 0.1043 | 0.6451 |
Mycobacterium tuberculosis | Probable aldehyde dehydrogenase | 0.006 | 0.0548 | 0.4283 |
Brugia malayi | Thioredoxin reductase | 0.0047 | 0.0389 | 0.0367 |
Wolbachia endosymbiont of Brugia malayi | dihydrolipoamide dehydrogenase E3 component | 0.0016 | 0.0022 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0067 | 0.0638 | 0.0638 |
Trypanosoma brucei | trypanothione reductase | 0.0047 | 0.0389 | 1 |
Echinococcus granulosus | 5'partial|histone lysine N methyltransferase SETDB2 | 0.0028 | 0.0169 | 0.1621 |
Loa Loa (eye worm) | thioredoxin reductase | 0.0047 | 0.0389 | 0.0389 |
Mycobacterium tuberculosis | Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB | 0.0106 | 0.1107 | 0.8837 |
Mycobacterium tuberculosis | NADPH-dependent mycothiol reductase Mtr | 0.0047 | 0.0389 | 0.2985 |
Echinococcus multilocularis | Glycoside hydrolase, family 27 | 0.0101 | 0.1043 | 1 |
Brugia malayi | Pre-SET motif family protein | 0.0205 | 0.2296 | 0.2279 |
Plasmodium vivax | thioredoxin reductase, putative | 0.0047 | 0.0389 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | = 9 uM | Concentration required for 50% inhibition of Amyloid beta protein production in Amyloid precursor protein(APP)-transfected Chinese hamster ovary(CHO) cells | ChEMBL. | 10978191 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.