Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | protein kinase C, alpha | Starlite/ChEMBL | References |
Homo sapiens | protein kinase C, epsilon | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | protein kinase c iota type | 0.0035 | 0.1446 | 0.1446 |
Trichomonas vaginalis | AGC family protein kinase | 0.0021 | 0 | 0.5 |
Echinococcus multilocularis | Protein kinase C, brain isozyme | 0.0086 | 0.6463 | 0.6463 |
Echinococcus granulosus | protein kinase c epsilon type | 0.0122 | 1 | 1 |
Echinococcus granulosus | serine:threonine protein kinase N2 | 0.0084 | 0.6253 | 0.6253 |
Trichomonas vaginalis | AGC family protein kinase | 0.0021 | 0 | 0.5 |
Echinococcus multilocularis | RNA directed DNA polymerase | 0.0048 | 0.2671 | 0.2671 |
Brugia malayi | Protein kinase c protein 2 | 0.0066 | 0.4462 | 0.4462 |
Trichomonas vaginalis | AGC family protein kinase | 0.0021 | 0 | 0.5 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0086 | 0.6463 | 0.6463 |
Trichomonas vaginalis | AGC family protein kinase | 0.0021 | 0 | 0.5 |
Echinococcus granulosus | protein kinase C gamma type | 0.0071 | 0.5017 | 0.5017 |
Trypanosoma brucei | rac serine-threonine kinase, putative | 0.0021 | 0 | 0.5 |
Trichomonas vaginalis | AGC family protein kinase | 0.0021 | 0 | 0.5 |
Trichomonas vaginalis | AGC family protein kinase | 0.0021 | 0 | 0.5 |
Echinococcus multilocularis | serine:threonine protein kinase N2 | 0.0104 | 0.8254 | 0.8254 |
Loa Loa (eye worm) | hypothetical protein | 0.0048 | 0.2671 | 0.2671 |
Entamoeba histolytica | PH domain containing protein kinase, putative | 0.0084 | 0.6253 | 1 |
Echinococcus multilocularis | serine threonine protein kinase | 0.0071 | 0.5017 | 0.5017 |
Loa Loa (eye worm) | AGC/PKC/ETA protein kinase | 0.0122 | 1 | 1 |
Schistosoma mansoni | atypical protein kinase C | 0.0035 | 0.1446 | 0.1446 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0122 | 1 | 1 |
Trichomonas vaginalis | AGC family protein kinase | 0.0021 | 0 | 0.5 |
Trichomonas vaginalis | AGC family protein kinase | 0.0021 | 0 | 0.5 |
Trichomonas vaginalis | AGC family protein kinase | 0.0021 | 0 | 0.5 |
Echinococcus granulosus | Protein kinase C brain isozyme | 0.0086 | 0.6463 | 0.6463 |
Loa Loa (eye worm) | AGC/PKC/ALPHA protein kinase | 0.0051 | 0.3016 | 0.3016 |
Trichomonas vaginalis | AGC family protein kinase | 0.0021 | 0 | 0.5 |
Echinococcus multilocularis | protein kinase c iota type | 0.0035 | 0.1446 | 0.1446 |
Echinococcus granulosus | RNA directed DNA polymerase | 0.0048 | 0.2671 | 0.2671 |
Echinococcus multilocularis | telomerase reverse transcriptase subunit | 0.0048 | 0.2671 | 0.2671 |
Trichomonas vaginalis | AGC family protein kinase | 0.0021 | 0 | 0.5 |
Echinococcus multilocularis | protein kinase c epsilon type | 0.0122 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0062 | 0.4117 | 0.4117 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0086 | 0.6463 | 0.6463 |
Toxoplasma gondii | AGC kinase | 0.0021 | 0 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Ki (binding) | = 4.1 nM | Displacement of [20-3H] phorbol 12, 13-dibutylate from recombinant PKCepsilon (unknown origin) in presence of 100 ug/ml 100% phosphatidylserine | ChEMBL. | 25437619 |
Ki (binding) | = 5.2 nM | Displacement of [20-3H] phorbol 12, 13-dibutylate from recombinant PKCepsilon (unknown origin) in presence of nuclear membrane mimetic lipid mixture | ChEMBL. | 25437619 |
Ki (binding) | = 8.26 nM | Displacement of [20-3H] phorbol 12, 13-dibutylate from recombinant PKCalpha (unknown origin) in presence of 100 ug/ml 100% phosphatidylserine | ChEMBL. | 25437619 |
Ki (binding) | = 25.7 nM | Displacement of [20-3H] phorbol 12, 13-dibutylate from recombinant PKCalpha (unknown origin) in presence of nuclear membrane mimetic lipid mixture | ChEMBL. | 25437619 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.