Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | protein tyrosine phosphatase, non-receptor type 2 | Starlite/ChEMBL | References |
Homo sapiens | protein tyrosine phosphatase, receptor type, A | Starlite/ChEMBL | References |
Homo sapiens | protein tyrosine phosphatase, non-receptor type 1 | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Echinococcus granulosus | receptor type tyrosine protein phosphatase zeta | protein tyrosine phosphatase, receptor type, A | 802 aa | 657 aa | 31.2 % |
Schistosoma mansoni | protein tyrosine phosphatase | protein tyrosine phosphatase, non-receptor type 2 | 410 aa | 335 aa | 25.7 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | Protein-tyrosine phosphatase containing protein | 0.0445 | 0 | 0.5 |
Echinococcus multilocularis | receptor type tyrosine protein phosphatase protein tyrosine phosphatase receptor type | 0.062 | 1 | 1 |
Echinococcus granulosus | receptor type tyrosine protein phosphatase | 0.062 | 1 | 1 |
Loa Loa (eye worm) | protein-tyrosine phosphatase | 0.0445 | 0 | 0.5 |
Schistosoma mansoni | protein tyrosine phosphatase non-receptor type nt1 | 0.0445 | 0 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Ki (binding) | = 6.9 | Inhibition of PTP1B | ChEMBL. | 19385614 |
Ki (binding) | = 6.92 | Inhibition of PTP1B (unknown origin) | LITERATURE. | No reference |
Ki (binding) | = 0.12 uM | Inhibitory activity against Protein-tyrosine phosphatase 1B (PTP 1B) was determined | ChEMBL. | 12877578 |
Ki (binding) | = 0.12 uM | Inhibitory activity against Protein-tyrosine phosphatase 1B (PTP 1B) was determined | ChEMBL. | 12877578 |
Ki (binding) | = 0.12 uM | Inhibition of human PTP1B (1 to 288 residues) expressed in Escherichia coli BL21 (DE3) cells using p-nitrophenyl phosphate as substrate monitered every 30 secs for 15 mins by micro plate reader method | ChEMBL. | 27353889 |
Ki (binding) | = 0.12 uM | Inhibition of PTP1B (unknown origin) | LITERATURE. | No reference |
Ki (binding) | = 0.47 uM | Inhibitory constant against T cell protein tyrosine phosphatase | ChEMBL. | 12877578 |
Ki (binding) | = 0.47 uM | Inhibitory constant against T cell protein tyrosine phosphatase | ChEMBL. | 12877578 |
Ki (binding) | = 0.47 uM | Inhibition of TCPTP (unknown origin) | ChEMBL. | 27353889 |
Ki (binding) | = 33 uM | Inhibitory activity against Leukocyte antigen related Tyrosine Phosphatase (Receptor linked protein tyrosine phosphatase LAR) was determined | ChEMBL. | 12877578 |
Ki (binding) | = 96 uM | Inhibitory activity against SH-domain containing phosphotyrosine phosphatase-2 (Tyrosine phosphatase SHP2) was determined | ChEMBL. | 12877578 |
Ki (binding) | = 96 uM | Inhibitory activity against SH-domain containing phosphotyrosine phosphatase-2 (Tyrosine phosphatase SHP2) was determined | ChEMBL. | 12877578 |
Ki (binding) | = 178 uM | Inhibitory activity against Cell division cycle 25 degree C was determined | ChEMBL. | 12877578 |
Ki (binding) | = 178 uM | Inhibitory activity against Cell division cycle 25 degree C was determined | ChEMBL. | 12877578 |
Ki (binding) | > 200 uM | Inhibitory activity against CD45 tyrosine phosphatase was determined | ChEMBL. | 12877578 |
Ki (binding) | > 200 uM | Inhibitory activity against (calcineurin) was determined | ChEMBL. | 12877578 |
Ki (binding) | > 200 uM | Inhibitory activity against CD45 tyrosine phosphatase was determined | ChEMBL. | 12877578 |
Ki (binding) | > 200 uM | Inhibitory activity against (calcineurin) was determined | ChEMBL. | 12877578 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
3 literature references were collected for this gene.