Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma cruzi | carbonic anhydrase-like protein, putative | 0.1184 | 0.7187 | 1 |
Brugia malayi | Carbonic anhydrase like protein 2 precursor | 0.0556 | 0.3226 | 0.4054 |
Onchocerca volvulus | 0.0075 | 0.0192 | 0.5 | |
Echinococcus multilocularis | carbonic anhydrase II | 0.1184 | 0.7187 | 1 |
Mycobacterium tuberculosis | Beta-carbonic anhydrase | 0.1082 | 0.6542 | 1 |
Entamoeba histolytica | ankyrin, putative | 0.0078 | 0.021 | 0.0273 |
Brugia malayi | Eukaryotic-type carbonic anhydrase family protein | 0.0556 | 0.3226 | 0.4054 |
Echinococcus granulosus | carbonic anhydrase | 0.0556 | 0.3226 | 0.4323 |
Brugia malayi | Eukaryotic-type carbonic anhydrase family protein | 0.1184 | 0.7187 | 1 |
Echinococcus granulosus | carbonic anhydrase | 0.0556 | 0.3226 | 0.4323 |
Trypanosoma cruzi | carbonic anhydrase-like protein, putative | 0.1184 | 0.7187 | 1 |
Toxoplasma gondii | hypothetical protein | 0.0556 | 0.3226 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0556 | 0.3226 | 0.4054 |
Mycobacterium ulcerans | carbonic anhydrase | 0.1267 | 0.7714 | 0.7714 |
Loa Loa (eye worm) | carbonic anhydrase 3 | 0.1184 | 0.7187 | 1 |
Brugia malayi | Carbonic anhydrase like protein 2 precursor | 0.0556 | 0.3226 | 0.4054 |
Echinococcus granulosus | carbonic anhydrase II | 0.1184 | 0.7187 | 1 |
Trypanosoma brucei | carbonic anhydrase-like protein | 0.1184 | 0.7187 | 1 |
Schistosoma mansoni | carbonic anhydrase II (carbonate dehydratase II) | 0.1184 | 0.7187 | 0.8827 |
Leishmania major | carbonic anhydrase-like protein | 0.1184 | 0.7187 | 0.9317 |
Entamoeba histolytica | acetyltransferase, putative | 0.0078 | 0.021 | 0.0273 |
Brugia malayi | Eukaryotic-type carbonic anhydrase family protein | 0.0556 | 0.3226 | 0.4054 |
Brugia malayi | Putative carbonic anhydrase 5 precursor | 0.1184 | 0.7187 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.163 | 1 | 1 |
Entamoeba histolytica | carbonic anhydrase, putative | 0.1267 | 0.7714 | 1 |
Mycobacterium leprae | CARBONIC ANHYDRASE (CARBONATE DEHYDRATASE) (CARBONIC DEHYDRATASE) | 0.1267 | 0.7714 | 1 |
Brugia malayi | Eukaryotic-type carbonic anhydrase family protein | 0.0556 | 0.3226 | 0.4054 |
Trichomonas vaginalis | conserved hypothetical protein | 0.163 | 1 | 1 |
Wolbachia endosymbiont of Brugia malayi | N-acetylglucosamine-1-phosphate uridyltransferase | 0.0078 | 0.021 | 1 |
Wolbachia endosymbiont of Brugia malayi | 2,3,4,5-tetrahydropyridine-2,6-carboxylate N-succinyltransferase | 0.0078 | 0.021 | 1 |
Schistosoma mansoni | carbonic anhydrase | 0.1267 | 0.7714 | 1 |
Echinococcus granulosus | carbonic anhydrase | 0.0556 | 0.3226 | 0.4323 |
Loa Loa (eye worm) | eukaryotic-type carbonic anhydrase | 0.0556 | 0.3226 | 0.4054 |
Mycobacterium tuberculosis | Beta-carbonic anhydrase CanB | 0.0719 | 0.4256 | 0.6505 |
Loa Loa (eye worm) | hypothetical protein | 0.0556 | 0.3226 | 0.4054 |
Plasmodium falciparum | carbonic anhydrase | 0.0556 | 0.3226 | 0.5 |
Mycobacterium ulcerans | transferase | 0.0075 | 0.0192 | 0.0192 |
Mycobacterium tuberculosis | Probable transmembrane carbonic anhydrase (carbonate dehydratase) (carbonic dehydratase) | 0.0548 | 0.3175 | 0.4853 |
Leishmania major | carbonic anhydrase family protein, putative | 0.1267 | 0.7714 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0556 | 0.3226 | 0.4054 |
Schistosoma mansoni | carbonic anhydrase II (carbonate dehydratase II) | 0.1184 | 0.7187 | 0.8827 |
Loa Loa (eye worm) | eukaryotic-type carbonic anhydrase | 0.1184 | 0.7187 | 1 |
Mycobacterium tuberculosis | Probable serine acetyltransferase CysE (sat) | 0.0078 | 0.021 | 0.0322 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
ED50 (functional) | > 10 mg kg-1 | Potentiation of 5-HT induced behavorial syndrome in pargyline-pretreated rats (ip) | ChEMBL. | 7200144 |
ED50 (functional) | > 20 mg kg-1 | Prevention of amphetamine aggregation toxicity in mice (po) | ChEMBL. | 7200144 |
ED50 (functional) | > 20 mg kg-1 | Prevention of amphetamine aggregation toxicity in mice (po) | ChEMBL. | 7200144 |
ED50 (functional) | > 40 mg kg-1 | Inhibition of pentylenetetrazol lethality in mice (po) | ChEMBL. | 7200144 |
ED50 (functional) | > 40 mg kg-1 | Inhibition of pentylenetetrazol lethality in mice (po) | ChEMBL. | 7200144 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.