TDR Targets

Basic information

Technical information

TDR Targets ID: 20250
Name: N-quinolin-2-yl-4-[3-(2H-tetrazol-5-yl)propox y]benzamide
MW: 374.396 | Formula: C20H18N6O2
H donors: 2 H acceptors: 5 LogP: 3.3 Rotable bonds: 8
Rule of 5 violations (Lipinski): 1
SMILES: O=C(c1ccc(cc1)OCCCc1nnn[nH]1)Nc1ccc2c(n1)cccc2
InChi: 1S/C20H18N6O2/c27-20(22-18-12-9-14-4-1-2-5-17(14)21-18)15-7-10-16(11-8-15)28-13-3-6-19-23-25-26-24-19/h1-2,4-5,7-12H,3,6,13H2,(H,21,22,27)(H,23,24,25,26)
InChiKey: OTKQFXXAASNTOH-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

N-(2-quinolyl)-4-[3-(2H-tetrazol-5-yl)propoxy]benzamide
N-quinolin-2-yl-4-[3-(2H-1,2,3,4-tetrazol-5-yl)propoxy]benzamide

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Echinococcus granulosus	neuropeptide receptor	0.0167	0.0172	0.0626
Echinococcus granulosus	glucan 14 alpha branching enzyme 1	0.0048	0.0035	0.0128
Toxoplasma gondii	1,4-alpha-glucan-branching enzyme	0.0048	0.0035	0.0091
Echinococcus granulosus	g protein coupled receptor	0.0167	0.0172	0.0626
Echinococcus granulosus	tm gpcr rhodopsin	0.0167	0.0172	0.0626
Schistosoma mansoni	histamine h1 receptor	0.0167	0.0172	0.0626
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0167	0.0172	0.0626
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0167	0.0172	0.0626
Trichomonas vaginalis	alpha-amylase, putative	0.0096	0.009	0.0694
Loa Loa (eye worm)	hypothetical protein	0.0167	0.0172	0.0172
Loa Loa (eye worm)	hypothetical protein	0.0167	0.0172	0.0172
Echinococcus multilocularis	tachykinin peptides receptor 99D	0.0167	0.0172	0.0626
Plasmodium falciparum	bifunctional dihydrofolate reductase-thymidylate synthase	0.3408	0.3879	1
Brugia malayi	sulfakinin receptor protein	0.8758	1	1
Schistosoma mansoni	histamine-responsive GPCR (AAF21638)	0.0167	0.0172	0.0626
Onchocerca volvulus		0.0167	0.0172	0.0626
Echinococcus multilocularis	G-protein coupled receptor, putative	0.0167	0.0172	0.0626
Brugia malayi	dihydrofolate reductase family protein	0.0987	0.111	0.111
Loa Loa (eye worm)	hypothetical protein	0.0167	0.0172	0.0172
Echinococcus multilocularis	growth hormone secretagogue receptor type 1	0.0167	0.0172	0.0626
Echinococcus multilocularis	thyrotropin releasing hormone receptor	0.0167	0.0172	0.0626
Loa Loa (eye worm)	hypothetical protein	0.0167	0.0172	0.0172
Schistosoma mansoni	neuropeptide receptor	0.0167	0.0172	0.0626
Loa Loa (eye worm)	hypothetical protein	0.0167	0.0172	0.0172
Loa Loa (eye worm)	hypothetical protein	0.0167	0.0172	0.0172
Schistosoma mansoni	dihydrofolate reductase	0.0987	0.111	0.4036
Loa Loa (eye worm)	hypothetical protein	0.0167	0.0172	0.0172
Brugia malayi	Serotonin receptor	0.0167	0.0172	0.0172
Loa Loa (eye worm)	hypothetical protein	0.0167	0.0172	0.0172
Echinococcus multilocularis	biogenic amine (5HT) receptor	0.0167	0.0172	0.0626
Schistosoma mansoni	amine GPCR	0.0167	0.0172	0.0626
Echinococcus granulosus	serotonin receptor	0.0167	0.0172	0.0626
Brugia malayi	Dopamine receptor protein 1, putative (partial)	0.0167	0.0172	0.0172
Brugia malayi	Tachykinin-like peptides receptor 99D	0.0167	0.0172	0.0172
Schistosoma mansoni	hypothetical protein	0.0167	0.0172	0.0626
Brugia malayi	Unidentified vitellogenin-linked transcript protein 6, putative	0.0167	0.0172	0.0172
Onchocerca volvulus		0.0167	0.0172	0.0626
Echinococcus granulosus	thymidylate synthase	0.2421	0.275	1
Mycobacterium ulcerans	dihydrofolate reductase DfrA	0.0987	0.111	0.3959
Brugia malayi	hypothetical protein	0.0167	0.0172	0.0172
Trypanosoma cruzi	dihydrofolate reductase-thymidylate synthase	0.3408	0.3879	1
Echinococcus multilocularis	neuropeptide Y receptor	0.0167	0.0172	0.0626
Echinococcus granulosus	peptide allatostatin:somatostatin	0.0167	0.0172	0.0626
Onchocerca volvulus	Neuropeptide F receptor homolog	0.0167	0.0172	0.0626
Leishmania major	cathepsin L-like protease	0.0064	0.0054	0.0139
Entamoeba histolytica	alpha-amylase family protein	0.0107	0.0104	1
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0167	0.0172	0.0626
Onchocerca volvulus		0.0167	0.0172	0.0626
Echinococcus multilocularis	sex peptide receptor	0.0167	0.0172	0.0626
Loa Loa (eye worm)	hypothetical protein	0.0167	0.0172	0.0172
Schistosoma mansoni	neuropeptide receptor	0.0167	0.0172	0.0626
Brugia malayi	hypothetical protein	0.0167	0.0172	0.0172
Echinococcus granulosus	fmrfamide receptor	0.0167	0.0172	0.0626
Brugia malayi	larval opioid receptor	0.0167	0.0172	0.0172
Schistosoma mansoni	neuropeptide f receptor 76f	0.0167	0.0172	0.0626
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0167	0.0172	0.0626
Loa Loa (eye worm)	hypothetical protein	0.0167	0.0172	0.0172
Brugia malayi	hypothetical protein	0.1152	0.1298	0.1298
Mycobacterium tuberculosis	Probable thymidylate synthase ThyA (ts) (TSASE)	0.2421	0.275	1
Loa Loa (eye worm)	thymidylate synthase	0.2421	0.275	0.275
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0167	0.0172	0.0626
Loa Loa (eye worm)	hypothetical protein	0.0167	0.0172	0.0172
Echinococcus granulosus	neuropeptides capa receptor	0.0167	0.0172	0.0626
Brugia malayi	G protein-coupled receptor	0.0167	0.0172	0.0172
Giardia lamblia	1,4-alpha-glucan branching enzyme	0.0048	0.0035	0.5
Loa Loa (eye worm)	hypothetical protein	0.0167	0.0172	0.0172
Echinococcus granulosus	allatostatin A receptor	0.0167	0.0172	0.0626
Brugia malayi	G-protein-linked acetylcholine receptor protein 2, putative	0.0167	0.0172	0.0172
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0167	0.0172	0.0626
Brugia malayi	GnHR receptor homolog	0.0167	0.0172	0.0172
Loa Loa (eye worm)	hypothetical protein	0.0167	0.0172	0.0172
Loa Loa (eye worm)	hypothetical protein	0.0167	0.0172	0.0172
Echinococcus granulosus	somatostatin receptor	0.0167	0.0172	0.0626
Leishmania major	dihydrofolate reductase-thymidylate synthase	0.3408	0.3879	1
Onchocerca volvulus		0.0167	0.0172	0.0626
Brugia malayi	RE15519p	0.0167	0.0172	0.0172
Brugia malayi	hypothetical protein	0.0167	0.0172	0.0172
Echinococcus multilocularis	fmrfamide receptor	0.0167	0.0172	0.0626
Loa Loa (eye worm)	hypothetical protein	0.0167	0.0172	0.0172
Schistosoma mansoni	peptide (FMRFamide/neurokinin-3)-like receptor	0.0167	0.0172	0.0626
Schistosoma mansoni	hypothetical protein	0.0167	0.0172	0.0626
Mycobacterium tuberculosis	Dihydrofolate reductase DfrA (DHFR) (tetrahydrofolate dehydrogenase)	0.0987	0.111	0.3959
Loa Loa (eye worm)	follicle stimulating hormone receptor	0.0167	0.0172	0.0172
Schistosoma mansoni	ancient conserved domain protein 2 (cyclin m2)	0.0167	0.0172	0.0626
Echinococcus granulosus	neuropeptide Y receptor	0.0167	0.0172	0.0626
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0167	0.0172	0.0626
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0167	0.0172	0.0626
Onchocerca volvulus		0.0167	0.0172	0.0626
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0167	0.0172	0.0626
Loa Loa (eye worm)	hypothetical protein	0.0167	0.0172	0.0172
Brugia malayi	Serotonin/octopamine receptor family protein 7	0.0167	0.0172	0.0172
Loa Loa (eye worm)	hypothetical protein	0.0167	0.0172	0.0172
Brugia malayi	hypothetical protein	0.0167	0.0172	0.0172
Echinococcus multilocularis	orexin receptor type 2	0.0167	0.0172	0.0626
Loa Loa (eye worm)	hypothetical protein	0.0167	0.0172	0.0172
Echinococcus granulosus	rhodopsin orphan GPCR	0.0167	0.0172	0.0626
Brugia malayi	hypothetical protein	0.0167	0.0172	0.0172
Loa Loa (eye worm)	hypothetical protein	0.0167	0.0172	0.0172
Onchocerca volvulus		0.0167	0.0172	0.0626
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0167	0.0172	0.0626
Echinococcus granulosus	tachykinin peptides receptor 99D	0.0167	0.0172	0.0626
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0167	0.0172	0.0626
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0167	0.0172	0.0626
Echinococcus multilocularis	7TM GPCR, rhodopsin	0.0167	0.0172	0.0626
Loa Loa (eye worm)	G-protein coupled receptor	0.0167	0.0172	0.0172
Brugia malayi	AKH receptor	0.0167	0.0172	0.0172
Echinococcus multilocularis	neuropeptides capa receptor	0.0167	0.0172	0.0626
Trichomonas vaginalis	alpha-amylase, putative	0.0107	0.0104	0.0798
Trypanosoma cruzi	cysteine peptidase, putative	0.0064	0.0054	0.0139
Echinococcus granulosus	orexin receptor type 2	0.0167	0.0172	0.0626
Schistosoma mansoni	bifunctional dihydrofolate reductase-thymidylate synthase	0.2421	0.275	1
Brugia malayi	G-protein coupled receptor	0.0167	0.0172	0.0172
Echinococcus multilocularis	g protein coupled receptor	0.0167	0.0172	0.0626
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0167	0.0172	0.0626
Schistosoma mansoni	amine GPCR	0.0167	0.0172	0.0626
Echinococcus multilocularis	neuropeptide s receptor	0.0167	0.0172	0.0626
Loa Loa (eye worm)	melatonin receptor type 1A	0.0167	0.0172	0.0172
Loa Loa (eye worm)	hypothetical protein	0.0167	0.0172	0.0172
Brugia malayi	1,4-alpha-glucan branching enzyme	0.0048	0.0035	0.0035
Brugia malayi	G-protein coupled receptor	0.0167	0.0172	0.0172
Echinococcus granulosus	dro:myosuppressin receptor	0.0167	0.0172	0.0626
Schistosoma mansoni	neuropeptide receptor	0.0167	0.0172	0.0626
Echinococcus multilocularis	g protein coupled receptor	0.0167	0.0172	0.0626
Entamoeba histolytica	alpha-amylase family protein	0.0107	0.0104	1
Echinococcus granulosus	neuropeptide receptor	0.0167	0.0172	0.0626
Schistosoma mansoni	neuropeptide receptor	0.0167	0.0172	0.0626
Echinococcus multilocularis	dro:myosuppressin receptor	0.0167	0.0172	0.0626
Loa Loa (eye worm)	hypothetical protein	0.0167	0.0172	0.0172
Echinococcus multilocularis	serotonin receptor	0.0167	0.0172	0.0626
Echinococcus multilocularis	pyroglutamylated rfamide peptide receptor	0.0167	0.0172	0.0626
Echinococcus granulosus	g-protein coupled receptor	0.0167	0.0172	0.0626
Schistosoma mansoni	neuropeptide F-like receptor	0.0167	0.0172	0.0626
Echinococcus granulosus	hypothetical protein	0.0167	0.0172	0.0626
Echinococcus granulosus	g protein coupled receptor	0.0167	0.0172	0.0626
Loa Loa (eye worm)	hypothetical protein	0.0167	0.0172	0.0172
Loa Loa (eye worm)	hypothetical protein	0.0048	0.0035	0.0035
Schistosoma mansoni	neuropeptide F-like receptor	0.0167	0.0172	0.0626
Brugia malayi	Dopamine receptor protein 2	0.0167	0.0172	0.0172
Echinococcus granulosus	rhodopsin orphan GPCR	0.0167	0.0172	0.0626
Onchocerca volvulus		0.0167	0.0172	0.0626
Brugia malayi	thymidylate synthase	0.2421	0.275	0.275
Chlamydia trachomatis	dihydrofolate reductase	0.0987	0.111	1
Schistosoma mansoni	opsin-like receptor	0.0167	0.0172	0.0626
Brugia malayi	putative neuropeptide receptor	0.0167	0.0172	0.0172
Loa Loa (eye worm)	hypothetical protein	0.0167	0.0172	0.0172
Onchocerca volvulus		0.0167	0.0172	0.0626
Onchocerca volvulus	Dopamine\/Ecdysteroid receptor homolog	0.0167	0.0172	0.0626
Loa Loa (eye worm)	hypothetical protein	0.0167	0.0172	0.0172
Trichomonas vaginalis	alpha-amylase, putative	0.0107	0.0104	0.0798
Echinococcus granulosus	rhodopsin orphan GPCR	0.0167	0.0172	0.0626
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0167	0.0172	0.0626
Onchocerca volvulus		0.0167	0.0172	0.0626
Schistosoma mansoni	amine GPCR	0.0167	0.0172	0.0626
Mycobacterium ulcerans	thymidylate synthase	0.2421	0.275	1
Brugia malayi	gonadotropin-releasing hormone receptor 2	0.0167	0.0172	0.0172
Brugia malayi	G protein-coupled receptor F59B2.13	0.0167	0.0172	0.0172
Echinococcus granulosus	rhodopsin orphan GPCR	0.0167	0.0172	0.0626
Loa Loa (eye worm)	hypothetical protein	0.0167	0.0172	0.0172
Echinococcus granulosus	neuropeptide Y receptor	0.0167	0.0172	0.0626
Loa Loa (eye worm)	hypothetical protein	0.0167	0.0172	0.0172
Echinococcus multilocularis	G protein coupled 5 hydroxytryptamine receptor	0.0167	0.0172	0.0626
Echinococcus granulosus	biogenic amine 5HT receptor	0.0167	0.0172	0.0626
Echinococcus granulosus	rhodopsin orphan GPCR	0.0167	0.0172	0.0626
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0167	0.0172	0.0626
Brugia malayi	hypothetical protein	0.0167	0.0172	0.0172
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0167	0.0172	0.0626
Brugia malayi	Melatonin receptor type 1A	0.0167	0.0172	0.0172
Echinococcus multilocularis	neuropeptides capa receptor	0.0167	0.0172	0.0626
Echinococcus granulosus	thyrotropin releasing hormone receptor	0.0167	0.0172	0.0626
Schistosoma mansoni	hypothetical protein	0.0167	0.0172	0.0626
Schistosoma mansoni	peptide (allatostatin/somatostatin)-like receptor	0.0167	0.0172	0.0626
Echinococcus granulosus	neuropeptides capa receptor	0.0167	0.0172	0.0626
Loa Loa (eye worm)	hypothetical protein	0.0167	0.0172	0.0172
Trypanosoma cruzi	dihydrofolate reductase-thymidylate synthase, putative	0.1152	0.1298	0.3346
Echinococcus multilocularis	allatostatin A receptor	0.0167	0.0172	0.0626
Echinococcus multilocularis	neuropeptide receptor	0.0167	0.0172	0.0626
Echinococcus multilocularis	neuropeptide receptor A26	0.0167	0.0172	0.0626
Echinococcus granulosus	7TM GPCR rhodopsin	0.0167	0.0172	0.0626
Loa Loa (eye worm)	hypothetical protein	0.0167	0.0172	0.0172
Onchocerca volvulus		0.0167	0.0172	0.0626
Echinococcus granulosus	G protein coupled receptor 139	0.0167	0.0172	0.0626
Echinococcus granulosus	7tm_1 domain containing protein	0.0167	0.0172	0.0626
Trypanosoma brucei	dihydrofolate reductase-thymidylate synthase	0.3408	0.3879	1
Echinococcus multilocularis	thymidylate synthase	0.2421	0.275	1
Mycobacterium tuberculosis	Hypothetical protein	0.1152	0.1298	0.4652
Schistosoma mansoni	biogenic amine (octopamine/dopamine) receptor	0.0167	0.0172	0.0626
Echinococcus granulosus	dihydrofolate reductase	0.0987	0.111	0.4036
Echinococcus granulosus	sex peptide receptor	0.0167	0.0172	0.0626
Loa Loa (eye worm)	hypothetical protein	0.0167	0.0172	0.0172
Echinococcus multilocularis	alpha 1A adrenergic receptor	0.0167	0.0172	0.0626
Loa Loa (eye worm)	hypothetical protein	0.0167	0.0172	0.0172
Loa Loa (eye worm)	hypothetical protein	0.0167	0.0172	0.0172
Loa Loa (eye worm)	hypothetical protein	0.0167	0.0172	0.0172
Mycobacterium leprae	PROBABLE THYMIDYLATE SYNTHASE THYA (TS) (TSASE)	0.2421	0.275	1
Loa Loa (eye worm)	TYRA-2 protein	0.0167	0.0172	0.0172
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0167	0.0172	0.0626
Onchocerca volvulus		0.0167	0.0172	0.0626
Schistosoma mansoni	adenoreceptor	0.0167	0.0172	0.0626
Loa Loa (eye worm)	gonadotropin-releasing hormone receptor 2	0.0167	0.0172	0.0172
Echinococcus granulosus	biogenic amine 5HT receptor	0.0167	0.0172	0.0626
Trichomonas vaginalis	amylase, putative	0.0107	0.0104	0.0798
Schistosoma mansoni	amine GPCR	0.0167	0.0172	0.0626
Schistosoma mansoni	thyrotropin-releasing hormone receptor	0.0167	0.0172	0.0626
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0167	0.0172	0.0626
Trypanosoma cruzi	cysteine peptidase, putative	0.0064	0.0054	0.0139
Brugia malayi	ORL1-like opioid receptor	0.0167	0.0172	0.0172
Schistosoma mansoni	alpha-1 adrenergic receptor	0.0167	0.0172	0.0626
Echinococcus multilocularis	fmrfamide receptor	0.0167	0.0172	0.0626
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0167	0.0172	0.0626
Loa Loa (eye worm)	5-hydroxytryptamine 2C receptor	0.0167	0.0172	0.0172
Brugia malayi	neuropeptide F receptor	0.0167	0.0172	0.0172
Brugia malayi	hypothetical protein	0.0167	0.0172	0.0172
Echinococcus multilocularis	neuropeptide Y receptor	0.0167	0.0172	0.0626
Echinococcus granulosus	rhodopsin orphan GPCR	0.0167	0.0172	0.0626
Onchocerca volvulus		0.0167	0.0172	0.0626
Echinococcus granulosus	pyroglutamylated rfamide peptide receptor	0.0167	0.0172	0.0626
Loa Loa (eye worm)	hypothetical protein	0.0167	0.0172	0.0172
Loa Loa (eye worm)	dihydrofolate reductase	0.0987	0.111	0.111
Trypanosoma cruzi	cysteine peptidase, clan CA, family C1, cathepsin L-like, putative	0.0059	0.0048	0.0123
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0167	0.0172	0.0626
Schistosoma mansoni	hypothetical protein	0.0167	0.0172	0.0626
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0167	0.0172	0.0626
Echinococcus granulosus	neuropeptide s receptor	0.0167	0.0172	0.0626
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0167	0.0172	0.0626
Loa Loa (eye worm)	hypothetical protein	0.0167	0.0172	0.0172
Onchocerca volvulus		0.0167	0.0172	0.0626
Toxoplasma gondii	alpha amylase, catalytic domain-containing protein	0.0048	0.0035	0.0091
Loa Loa (eye worm)	hypothetical protein	0.0167	0.0172	0.0172
Schistosoma mansoni	growth hormone secretagogue receptor	0.0167	0.0172	0.0626
Schistosoma mansoni	biogenic amine receptor	0.0167	0.0172	0.0626
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0167	0.0172	0.0626
Brugia malayi	Dihydrofolate reductase	0.0987	0.111	0.111
Echinococcus granulosus	alpha 1A adrenergic receptor	0.0167	0.0172	0.0626
Plasmodium vivax	bifunctional dihydrofolate reductase-thymidylate synthase, putative	0.3408	0.3879	1
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0167	0.0172	0.0626
Toxoplasma gondii	glycosyltransferase	0.0048	0.0035	0.0091
Trypanosoma cruzi	cruzipain precursor, putative	0.0064	0.0054	0.0139
Echinococcus multilocularis	glucan (1,4 alpha), branching enzyme 1	0.0048	0.0035	0.0128
Echinococcus granulosus	neuropeptide receptor A26	0.0167	0.0172	0.0626
Schistosoma mansoni	opsin-like receptor	0.0167	0.0172	0.0626
Schistosoma mansoni	opsin-like receptor	0.0167	0.0172	0.0626
Echinococcus multilocularis	serotonin receptor	0.0167	0.0172	0.0626
Brugia malayi	Serotonin receptor	0.0167	0.0172	0.0172
Echinococcus granulosus	G protein coupled 5 hydroxytryptamine receptor	0.0167	0.0172	0.0626
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0167	0.0172	0.0626
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0167	0.0172	0.0626
Onchocerca volvulus		0.0167	0.0172	0.0626
Trichomonas vaginalis	starch branching enzyme II, putative	0.0048	0.0035	0.0272
Loa Loa (eye worm)	hypothetical protein	0.0167	0.0172	0.0172
Loa Loa (eye worm)	hypothetical protein	0.0167	0.0172	0.0172
Onchocerca volvulus		0.2421	0.275	1
Brugia malayi	follicle stimulating hormone receptor	0.0167	0.0172	0.0172
Loa Loa (eye worm)	G-protein coupled receptor	0.0167	0.0172	0.0172
Loa Loa (eye worm)	hypothetical protein	0.0167	0.0172	0.0172
Brugia malayi	hypothetical protein	0.0167	0.0172	0.0172
Trichomonas vaginalis	alpha-amylase, putative	0.0107	0.0104	0.0798
Loa Loa (eye worm)	hypothetical protein	0.0167	0.0172	0.0172
Loa Loa (eye worm)	hypothetical protein	0.0167	0.0172	0.0172
Trichomonas vaginalis	alpha-amylase, putative	0.0107	0.0104	0.0798
Echinococcus multilocularis	g protein coupled receptor	0.0167	0.0172	0.0626
Trichomonas vaginalis	conserved hypothetical protein	0.1152	0.1298	1
Loa Loa (eye worm)	neuropeptide F receptor	0.0167	0.0172	0.0172
Echinococcus multilocularis	g-protein coupled receptor	0.0167	0.0172	0.0626
Brugia malayi	putative neuropeptide receptor NPR1	0.0167	0.0172	0.0172
Echinococcus multilocularis	neuropeptide receptor	0.0167	0.0172	0.0626
Loa Loa (eye worm)	unidentified vitellogenin-linked transcript protein 6	0.0167	0.0172	0.0172
Echinococcus multilocularis	neuropeptide FF receptor 2	0.0167	0.0172	0.0626
Trichomonas vaginalis	amylase, putative	0.0107	0.0104	0.0798
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0167	0.0172	0.0626
Echinococcus granulosus	rhodopsin orphan GPCR	0.0167	0.0172	0.0626
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0167	0.0172	0.0626
Echinococcus granulosus	tm gpcr rhodopsin	0.0167	0.0172	0.0626
Entamoeba histolytica	1,4-alpha-glucan branching enzyme, putative	0.0048	0.0035	0.3408
Schistosoma mansoni	biogenic amine receptor	0.0167	0.0172	0.0626
Loa Loa (eye worm)	hypothetical protein	0.0167	0.0172	0.0172
Echinococcus multilocularis	G protein coupled receptor 139	0.0167	0.0172	0.0626
Trypanosoma cruzi	major cysteine proteinase, putative	0.005	0.0038	0.0099
Schistosoma mansoni	amine GPCR	0.0167	0.0172	0.0626
Echinococcus granulosus	growth hormone secretagogue receptor type 1	0.0167	0.0172	0.0626
Brugia malayi	Dopamine receptor	0.0167	0.0172	0.0172
Echinococcus multilocularis	dihydrofolate reductase	0.0987	0.111	0.4036
Toxoplasma gondii	bifunctional dihydrofolate reductase-thymidylate synthase	0.3408	0.3879	1
Onchocerca volvulus		0.0167	0.0172	0.0626
Echinococcus granulosus	g protein coupled receptor	0.0167	0.0172	0.0626
Brugia malayi	neuropeptide F receptor	0.0167	0.0172	0.0172
Schistosoma mansoni	peptide (allatostatin)-like receptor	0.0167	0.0172	0.0626
Schistosoma mansoni	biogenic amine receptor	0.0167	0.0172	0.0626
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0167	0.0172	0.0626
Brugia malayi	hypothetical protein	0.0167	0.0172	0.0172
Schistosoma mansoni	myosin xvIII	0.0167	0.0172	0.0626
Echinococcus granulosus	tm gpcr rhodopsin	0.0167	0.0172	0.0626
Loa Loa (eye worm)	neuropeptide F receptor	0.0167	0.0172	0.0172
Entamoeba histolytica	1,4-alpha-glucan branching enzyme, putative	0.0048	0.0035	0.3408
Loa Loa (eye worm)	hypothetical protein	0.0167	0.0172	0.0172
Echinococcus multilocularis	somatostatin receptor	0.0167	0.0172	0.0626
Trichomonas vaginalis	amylase, putative	0.0048	0.0035	0.0272
Schistosoma mansoni	muscarinic acetylcholine (GAR) receptor	0.0167	0.0172	0.0626
Trypanosoma cruzi	cysteine peptidase, putative	0.0064	0.0054	0.0139
Echinococcus granulosus	neuropeptide FF receptor 2	0.0167	0.0172	0.0626
Schistosoma mansoni	starch branching enzyme II	0.0048	0.0035	0.0128
Leishmania major	cathepsin L-like protease	0.0064	0.0054	0.0139
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0167	0.0172	0.0626
Onchocerca volvulus		0.0167	0.0172	0.0626
Leishmania major	cathepsin L-like protease	0.0064	0.0054	0.0139
Loa Loa (eye worm)	hypothetical protein	0.8758	1	1
Loa Loa (eye worm)	hypothetical protein	0.0167	0.0172	0.0172
Loa Loa (eye worm)	hypothetical protein	0.0167	0.0172	0.0172
Brugia malayi	Dopamine receptor protein 1	0.0167	0.0172	0.0172
Loa Loa (eye worm)	G-protein-linked acetylcholine receptor protein 2	0.0167	0.0172	0.0172
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0167	0.0172	0.0626
Echinococcus multilocularis	peptide (allatostatin:somatostatin)	0.0167	0.0172	0.0626
Onchocerca volvulus		0.0167	0.0172	0.0626

Activities

Activity type	Activity value	Assay description	Source	Reference
Inhibition (binding)	= 33 %	Binding affinity at 10 uM against Cysteinyl leukotriene D4 receptor from guinea pig lung by [3H]-LTD4 (0.2 nM) displacement.	ChEMBL.	2157009
Inhibition (binding)	= 33 %	Binding affinity at 10 uM against Cysteinyl leukotriene D4 receptor from guinea pig lung by [3H]-LTD4 (0.2 nM) displacement.	ChEMBL.	2157009
Inhibition (functional)	= 43 %	inhibition of the spasmogenic activity of LTD4 in guinea pig parenchymal strips at 10 uM.	ChEMBL.	2157009
Inhibition (functional)	= 43 %	inhibition of the spasmogenic activity of LTD4 in guinea pig parenchymal strips at 10 uM.	ChEMBL.	2157009

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL18340
PubChem: 14650367

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 20250