Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Sus scrofa | Prolyl endopeptidase | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Trypanosoma brucei gambiense | oligopeptidase B, putative | Prolyl endopeptidase | 710 aa | 629 aa | 26.4 % |
Leishmania infantum | oligopeptidase b;with=GeneDB:LmjF09.0770 | Prolyl endopeptidase | 710 aa | 743 aa | 24.4 % |
Leishmania mexicana | oligopeptidase b,serine peptidase, clan SC, family S9A-like protein | Prolyl endopeptidase | 710 aa | 720 aa | 24.7 % |
Mycobacterium ulcerans | protease II (oligopeptidase B), PtrB | Prolyl endopeptidase | 710 aa | 714 aa | 26.5 % |
Trypanosoma cruzi | oligopeptidase b | Prolyl endopeptidase | 710 aa | 719 aa | 25.6 % |
Trypanosoma cruzi | oligopeptidase b | Prolyl endopeptidase | 710 aa | 719 aa | 25.6 % |
Onchocerca volvulus | Prolyl endopeptidase | 710 aa | 722 aa | 47.6 % | |
Trypanosoma brucei | oligopeptidase b | Prolyl endopeptidase | 710 aa | 630 aa | 26.3 % |
Leishmania donovani | oligopeptidase b | Prolyl endopeptidase | 710 aa | 743 aa | 24.4 % |
Leishmania major | oligopeptidase b | Prolyl endopeptidase | 710 aa | 743 aa | 24.9 % |
Leishmania braziliensis | oligopeptidase b;with=GeneDB:LmjF09.0770 | Prolyl endopeptidase | 710 aa | 608 aa | 26.0 % |
Mycobacterium leprae | PROBABLE PROTEASE II PTRBB (OLIGOPEPTIDASE B) | Prolyl endopeptidase | 710 aa | 741 aa | 25.6 % |
Trypanosoma congolense | oligopeptidase b | Prolyl endopeptidase | 710 aa | 589 aa | 27.8 % |
Dictyostelium discoideum | oligopeptidase B | Prolyl endopeptidase | 710 aa | 735 aa | 23.7 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0277 | 0.8476 | 0.7875 |
Trypanosoma brucei | prolyl endopeptidase | 0.0158 | 0.3766 | 1 |
Echinococcus granulosus | prolyl endopeptidase | 0.0158 | 0.3766 | 1 |
Schistosoma mansoni | biogenic amine (octopamine/dopamine) receptor | 0.0316 | 1 | 1 |
Schistosoma mansoni | prolyl oligopeptidase (S09 family) | 0.0158 | 0.3766 | 0.1308 |
Onchocerca volvulus | Prolyl endopeptidase homolog | 0.0158 | 0.3766 | 0.5 |
Leishmania major | prolyl oligopeptidase, putative,serine peptidase clan SC, family S9A, putative | 0.0158 | 0.3766 | 1 |
Echinococcus multilocularis | prolyl endopeptidase | 0.0158 | 0.3766 | 1 |
Schistosoma mansoni | prolyl oligopeptidase (S09 family) | 0.0158 | 0.3766 | 0.1308 |
Toxoplasma gondii | prolyl endopeptidase | 0.0158 | 0.3766 | 0.5 |
Mycobacterium tuberculosis | Probable protease II PtrBa [first part] (oligopeptidase B) | 0.0142 | 0.311 | 1 |
Mycobacterium ulcerans | protease II (oligopeptidase B), PtrB | 0.0063 | 0 | 0.5 |
Mycobacterium leprae | PROBABLE PROTEASE II PTRBB (OLIGOPEPTIDASE B) | 0.0063 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0316 | 1 | 1 |
Trypanosoma cruzi | prolyl endopeptidase | 0.0158 | 0.3766 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0158 | 0.3766 | 0.1308 |
Loa Loa (eye worm) | hypothetical protein | 0.0316 | 1 | 1 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.