Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | glutamate receptor, metabotropic 2 | Starlite/ChEMBL | References |
Homo sapiens | glutamate receptor, metabotropic 3 | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | kelch domain-containing protein family protein | 0.0149 | 0.0307 | 0.0307 |
Echinococcus multilocularis | integrin beta 2 | 0.0726 | 0.6953 | 1 |
Schistosoma mansoni | metabotropic glutamate receptor 2 3 (mglur group 2) | 0.0139 | 0.0193 | 0.0019 |
Echinococcus granulosus | metabotropic glutamate receptor 5 | 0.015 | 0.0325 | 0.0212 |
Schistosoma mansoni | integrin alpha-ps | 0.015 | 0.0319 | 0.0236 |
Loa Loa (eye worm) | integrin beta-2 | 0.098 | 0.9879 | 0.9879 |
Brugia malayi | Integrin alpha cytoplasmic region family protein | 0.0486 | 0.419 | 0.4241 |
Brugia malayi | hypothetical protein | 0.0149 | 0.0307 | 0.031 |
Loa Loa (eye worm) | hypothetical protein | 0.0149 | 0.0307 | 0.0307 |
Loa Loa (eye worm) | hypothetical protein | 0.0486 | 0.419 | 0.419 |
Echinococcus granulosus | integrin alpha ps | 0.0288 | 0.1909 | 0.2551 |
Loa Loa (eye worm) | hypothetical protein | 0.015 | 0.0319 | 0.0319 |
Brugia malayi | Integrin alpha pat-2 precursor | 0.0642 | 0.5992 | 0.6066 |
Echinococcus multilocularis | integrin alpha ps | 0.0288 | 0.1909 | 0.2551 |
Schistosoma mansoni | integrin beta subunit | 0.0577 | 0.5238 | 0.8702 |
Brugia malayi | Kelch motif family protein | 0.0149 | 0.0307 | 0.031 |
Echinococcus multilocularis | metabotropic glutamate receptor 5 | 0.015 | 0.0325 | 0.0212 |
Schistosoma mansoni | integrin alpha-ps | 0.0288 | 0.1909 | 0.2973 |
Echinococcus multilocularis | integrin alpha 3 | 0.0492 | 0.4265 | 0.603 |
Echinococcus multilocularis | integrin alpha ps | 0.0288 | 0.1909 | 0.2551 |
Loa Loa (eye worm) | hypothetical protein | 0.0138 | 0.0182 | 0.0182 |
Echinococcus granulosus | integrin alpha 3 | 0.0492 | 0.4265 | 0.603 |
Loa Loa (eye worm) | hypothetical protein | 0.0354 | 0.2674 | 0.2674 |
Brugia malayi | Integrin beta pat-3 precursor | 0.098 | 0.9879 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.015 | 0.0325 | 0.0325 |
Loa Loa (eye worm) | hypothetical protein | 0.0504 | 0.4402 | 0.4402 |
Schistosoma mansoni | integrin alpha | 0.0642 | 0.5992 | 1 |
Echinococcus granulosus | integrin beta 2 | 0.0726 | 0.6953 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | > 10 uM | Inhibitory activity for Group II Metabotropic glutamate receptor in rat forebrain membranes by using [3H]-glutamate radioligand | ChEMBL. | 9464366 |
IC50 (functional) | > 10 uM | Ability to block 1S,3R-ACPD-induced inhibition of forskolin stimulated cyclic-AMP in non-neuronal cell line expressing human Metabotropic glutamate receptor 2 | ChEMBL. | 9464366 |
IC50 (functional) | > 10 uM | Ability to block 1S,3R-ACPD-induced inhibition of forskolin stimulated cyclic-AMP in non-neuronal cell line expressing human Metabotropic glutamate receptor 3 | ChEMBL. | 9464366 |
IC50 (functional) | > 10 uM | Ability to block 1S,3R-ACPD-induced inhibition of forskolin stimulated cyclic-AMP in non-neuronal cell line expressing human Metabotropic glutamate receptor 2 | ChEMBL. | 9464366 |
IC50 (functional) | > 10 uM | Ability to block 1S,3R-ACPD-induced inhibition of forskolin stimulated cyclic-AMP in non-neuronal cell line expressing human Metabotropic glutamate receptor 3 | ChEMBL. | 9464366 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.