Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma cruzi | multidrug resistance protein E, putative | 0.0082 | 0.0448 | 1 |
Echinococcus multilocularis | multidrug resistance associated protein 7 | 0.0082 | 0.0448 | 1 |
Trypanosoma brucei | p-glycoprotein | 0.0082 | 0.0448 | 0.5 |
Entamoeba histolytica | hypothetical protein | 0.0082 | 0.0448 | 0.5 |
Leishmania major | ABC-thiol transporter | 0.0082 | 0.0448 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0081 | 0.0433 | 0.0418 |
Loa Loa (eye worm) | ABC transporter transmembrane region family protein | 0.0082 | 0.0448 | 0.0433 |
Leishmania major | ATP-binding cassette protein subfamily C, member 5, putative | 0.0082 | 0.0448 | 0.5 |
Entamoeba histolytica | ATP-binding cassette protein, putative | 0.0082 | 0.0448 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0082 | 0.0448 | 0.0433 |
Leishmania major | pentamidine resistance protein 1 | 0.0082 | 0.0448 | 0.5 |
Giardia lamblia | Multidrug resistance-associated protein 1 | 0.0082 | 0.0448 | 1 |
Leishmania major | ATP-binding cassette protein subfamily C, member 2, putative | 0.0082 | 0.0448 | 0.5 |
Giardia lamblia | ABC transporter, putative | 0.0082 | 0.0448 | 1 |
Trypanosoma cruzi | multidrug resistance-associated protein, putative | 0.0082 | 0.0448 | 1 |
Schistosoma mansoni | multidrug resistance protein | 0.0082 | 0.0448 | 0.5 |
Entamoeba histolytica | ABC transporter, putative | 0.0082 | 0.0448 | 0.5 |
Toxoplasma gondii | hypothetical protein | 0.0487 | 1 | 1 |
Entamoeba histolytica | multidrug resistance protein, putative | 0.0082 | 0.0448 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0487 | 1 | 1 |
Giardia lamblia | MRP-like ABC transporter | 0.0082 | 0.0448 | 1 |
Entamoeba histolytica | ATP-binding cassette protein, putative | 0.0082 | 0.0448 | 0.5 |
Giardia lamblia | Multidrug resistance-associated protein 1 | 0.0082 | 0.0448 | 1 |
Leishmania major | ATP-binding cassette protein subfamily C, member 1, putative | 0.0082 | 0.0448 | 0.5 |
Trypanosoma cruzi | multidrug resistance-associated protein, putative | 0.0082 | 0.0448 | 1 |
Trypanosoma brucei | multidrug resistance-associated protein, putative | 0.0082 | 0.0448 | 0.5 |
Echinococcus multilocularis | multidrug resistance associated protein 1 | 0.0082 | 0.0448 | 1 |
Schistosoma mansoni | multidrug resistance protein | 0.0082 | 0.0448 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0082 | 0.0448 | 0.0433 |
Schistosoma mansoni | multidrug resistance protein | 0.0082 | 0.0448 | 0.5 |
Entamoeba histolytica | ATP-binding cassette protein, putative | 0.0082 | 0.0448 | 0.5 |
Echinococcus granulosus | multidrug resistance associated protein 1 | 0.0082 | 0.0448 | 1 |
Trypanosoma brucei | multidrug resistance protein E | 0.0082 | 0.0448 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0487 | 1 | 1 |
Brugia malayi | multidrug resistance related protein 1 | 0.0082 | 0.0448 | 0.5 |
Entamoeba histolytica | ATP-binding cassette protein, putative | 0.0082 | 0.0448 | 0.5 |
Leishmania major | ATP-binding cassette protein subfamily C, member 6, putative | 0.0082 | 0.0448 | 0.5 |
Trypanosoma brucei | multidrug resistance-associated protein, putative | 0.0082 | 0.0448 | 0.5 |
Echinococcus granulosus | multidrug resistance associated protein 7 | 0.0082 | 0.0448 | 1 |
Loa Loa (eye worm) | inward rectifying k channel family protein 1 | 0.0487 | 1 | 1 |
Brugia malayi | ABC transporter transmembrane region family protein | 0.0082 | 0.0448 | 0.5 |
Leishmania major | p-glycoprotein e | 0.0082 | 0.0448 | 0.5 |
Schistosoma mansoni | multidrug resistance protein | 0.0082 | 0.0448 | 0.5 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.