Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium leprae | CARBONIC ANHYDRASE (CARBONATE DEHYDRATASE) (CARBONIC DEHYDRATASE) | 0.0928 | 0.7318 | 1 |
Echinococcus multilocularis | nuclear factor of activated T cells 5 | 0.0089 | 0.0574 | 0.0574 |
Echinococcus granulosus | carbonic anhydrase | 0.0491 | 0.3804 | 0.3804 |
Trypanosoma brucei | hypothetical protein, conserved | 0.0026 | 0.0067 | 0.004 |
Echinococcus multilocularis | carbonic anhydrase | 0.0491 | 0.3804 | 0.3804 |
Trypanosoma brucei | carbonic anhydrase-like protein | 0.1262 | 1 | 1 |
Wolbachia endosymbiont of Brugia malayi | 2,3,4,5-tetrahydropyridine-2,6-carboxylate N-succinyltransferase | 0.0045 | 0.0222 | 1 |
Leishmania major | carbonic anhydrase family protein, putative | 0.0928 | 0.7318 | 0.7299 |
Mycobacterium ulcerans | carbonic anhydrase | 0.0928 | 0.7318 | 0.9547 |
Toxoplasma gondii | hypothetical protein | 0.0491 | 0.3804 | 1 |
Mycobacterium ulcerans | hypothetical protein | 0.0026 | 0.0067 | 0.0053 |
Loa Loa (eye worm) | hypothetical protein | 0.0491 | 0.3804 | 0.3804 |
Loa Loa (eye worm) | carbonic anhydrase 3 | 0.1262 | 1 | 1 |
Mycobacterium ulcerans | carbonic anhydrase | 0.0971 | 0.7663 | 1 |
Echinococcus multilocularis | carbonic anhydrase | 0.0491 | 0.3804 | 0.3804 |
Plasmodium vivax | sulfate transporter, putative | 0.0021 | 0.0027 | 0.5 |
Plasmodium falciparum | carbonic anhydrase | 0.0491 | 0.3804 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.1249 | 0.9897 | 0.9897 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0026 | 0.0067 | 0.004 |
Echinococcus granulosus | carbonic anhydrase | 0.0491 | 0.3804 | 0.3804 |
Leishmania major | carbonic anhydrase-like protein | 0.1262 | 1 | 1 |
Schistosoma mansoni | carbonic anhydrase II (carbonate dehydratase II) | 0.1262 | 1 | 1 |
Trypanosoma cruzi | carbonic anhydrase-like protein, putative | 0.1262 | 1 | 1 |
Echinococcus multilocularis | carbonic anhydrase II | 0.1262 | 1 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0971 | 0.7663 | 1 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0026 | 0.0067 | 0.004 |
Echinococcus granulosus | carbonic anhydrase II | 0.1262 | 1 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0971 | 0.7663 | 1 |
Schistosoma mansoni | carbonic anhydrase | 0.0928 | 0.7318 | 0.5671 |
Echinococcus multilocularis | carbonic anhydrase | 0.0491 | 0.3804 | 0.3804 |
Mycobacterium tuberculosis | Probable serine acetyltransferase CysE (sat) | 0.0045 | 0.0222 | 0.0322 |
Mycobacterium tuberculosis | Probable conserved transmembrane protein | 0.0151 | 0.1075 | 0.2097 |
Trypanosoma cruzi | carbonic anhydrase-like protein, putative | 0.1262 | 1 | 1 |
Entamoeba histolytica | ankyrin, putative | 0.0045 | 0.0223 | 0.0215 |
Mycobacterium ulcerans | transferase | 0.0043 | 0.0208 | 0.0237 |
Mycobacterium tuberculosis | Probable transmembrane carbonic anhydrase (carbonate dehydratase) (carbonic dehydratase) | 0.0499 | 0.3867 | 0.7912 |
Loa Loa (eye worm) | eukaryotic-type carbonic anhydrase | 0.1262 | 1 | 1 |
Echinococcus granulosus | dynactin 5 p25 | 0.0045 | 0.0222 | 0.0222 |
Onchocerca volvulus | 0.0131 | 0.0911 | 1 | |
Entamoeba histolytica | carbonic anhydrase, putative | 0.0928 | 0.7318 | 1 |
Echinococcus granulosus | carbonic anhydrase | 0.0491 | 0.3804 | 0.3804 |
Onchocerca volvulus | Putative sulfate transporter | 0.0131 | 0.0911 | 1 |
Brugia malayi | Putative carbonic anhydrase 5 precursor | 0.1262 | 1 | 1 |
Echinococcus granulosus | nuclear factor of activated T cells 5 | 0.0089 | 0.0574 | 0.0574 |
Schistosoma mansoni | carbonic anhydrase II (carbonate dehydratase II) | 0.1262 | 1 | 1 |
Loa Loa (eye worm) | eukaryotic-type carbonic anhydrase | 0.0491 | 0.3804 | 0.3804 |
Mycobacterium leprae | Probable transmembrane transport protein | 0.0151 | 0.1075 | 0.1219 |
Chlamydia trachomatis | sulfate transporter | 0.0021 | 0.0027 | 0.5 |
Mycobacterium tuberculosis | Beta-carbonic anhydrase CanB | 0.0581 | 0.4525 | 0.928 |
Mycobacterium tuberculosis | Beta-carbonic anhydrase | 0.0624 | 0.487 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0491 | 0.3804 | 0.3804 |
Entamoeba histolytica | acetyltransferase, putative | 0.0045 | 0.0222 | 0.0213 |
Wolbachia endosymbiont of Brugia malayi | N-acetylglucosamine-1-phosphate uridyltransferase | 0.0045 | 0.0222 | 1 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.