Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma cruzi | inositol 1,4,5-trisphosphate receptor, putative | 0.005 | 0.4913 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0095 | 1 | 1 |
Loa Loa (eye worm) | ABC transporter transmembrane region family protein | 0.0006 | 0.0005 | 0.0009 |
Schistosoma mansoni | stromal cell-derived factor 2 precursor-like protein | 0.0009 | 0.0395 | 0.039 |
Echinococcus granulosus | ryanodine receptor 44f | 0.0033 | 0.3015 | 0.3011 |
Loa Loa (eye worm) | hypothetical protein | 0.0056 | 0.565 | 0.979 |
Giardia lamblia | Multidrug resistance-associated protein 1 | 0.0006 | 0.0005 | 1 |
Giardia lamblia | Multidrug resistance-associated protein 1 | 0.0006 | 0.0005 | 1 |
Mycobacterium tuberculosis | Probable epoxide hydrolase EphA (epoxide hydratase) (arene-oxide hydratase) | 0.0066 | 0.6758 | 0.5 |
Echinococcus multilocularis | ryanodine receptor 44f | 0.0042 | 0.4069 | 0.4066 |
Giardia lamblia | MRP-like ABC transporter | 0.0006 | 0.0005 | 1 |
Entamoeba histolytica | MIR domain protein | 0.0009 | 0.0395 | 1 |
Loa Loa (eye worm) | MIR domain-containing protein | 0.0009 | 0.0395 | 0.0685 |
Brugia malayi | Ryanodine Receptor TM 4-6 family protein | 0.0059 | 0.5943 | 0.6306 |
Trypanosoma brucei | inositol 1,4,5-trisphosphate receptor | 0.005 | 0.4913 | 1 |
Echinococcus multilocularis | geminin | 0.0095 | 1 | 1 |
Giardia lamblia | ABC transporter, putative | 0.0006 | 0.0005 | 1 |
Schistosoma mansoni | inositol 145-trisphosphate receptor | 0.0073 | 0.7548 | 0.7546 |
Schistosoma mansoni | ryanodine receptor related | 0.0059 | 0.5943 | 0.5941 |
Loa Loa (eye worm) | hypothetical protein | 0.0006 | 0.0005 | 0.0009 |
Echinococcus multilocularis | stromal cell derived factor 2 | 0.0009 | 0.0395 | 0.039 |
Loa Loa (eye worm) | hypothetical protein | 0.0057 | 0.5771 | 1 |
Loa Loa (eye worm) | ryanodine receptor | 0.0016 | 0.1141 | 0.1977 |
Loa Loa (eye worm) | hypothetical protein | 0.0048 | 0.4717 | 0.8174 |
Loa Loa (eye worm) | hypothetical protein | 0.0042 | 0.4069 | 0.705 |
Brugia malayi | MIR domain containing protein | 0.0009 | 0.0395 | 0.0414 |
Toxoplasma gondii | ABC transporter transmembrane region domain-containing protein | 0.0006 | 0.0005 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0095 | 1 | 1 |
Echinococcus granulosus | ryanodine receptor 44f | 0.0042 | 0.4069 | 0.4066 |
Leishmania major | hypothetical protein, conserved | 0.0034 | 0.3136 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0006 | 0.0005 | 0.0009 |
Schistosoma mansoni | ryanodine receptor 1 skeletal muscle | 0.0016 | 0.1141 | 0.1136 |
Brugia malayi | cation channel family protein | 0.009 | 0.9422 | 1 |
Onchocerca volvulus | 0.0009 | 0.0395 | 0.5 | |
Echinococcus multilocularis | ryanodine receptor 44f | 0.0033 | 0.3015 | 0.3011 |
Trichomonas vaginalis | mannosyltransferase 1, putative | 0.0009 | 0.0395 | 0.5 |
Echinococcus granulosus | stromal cell derived factor 2 | 0.0009 | 0.0395 | 0.039 |
Mycobacterium ulcerans | epoxide hydrolase EphA | 0.0066 | 0.6758 | 0.5 |
Schistosoma mansoni | inositol 145-trisphosphate receptor | 0.0048 | 0.4717 | 0.4715 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.