Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase | 0.0174 | 0.1681 | 0.1631 |
Loa Loa (eye worm) | hypothetical protein | 0.0066 | 0.0218 | 0.0218 |
Mycobacterium ulcerans | hydroxymethylglutaryl-coenzyme a (HMG-CoA) reductase | 0.0784 | 1 | 1 |
Trichomonas vaginalis | 3-hydroxy-3-methylglutaryl-coenzyme A reductase, putative | 0.0368 | 0.4327 | 1 |
Schistosoma mansoni | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0123 | 0.0996 | 0.0996 |
Trypanosoma cruzi | MFS transporter, putative | 0.0066 | 0.0218 | 0.0159 |
Echinococcus multilocularis | hydroxymethylglutaryl coenzyme A reductase | 0.0784 | 1 | 1 |
Loa Loa (eye worm) | thymidylate synthase | 0.0123 | 0.0996 | 0.0996 |
Onchocerca volvulus | 0.0123 | 0.0996 | 1 | |
Loa Loa (eye worm) | hypothetical protein | 0.009 | 0.0539 | 0.0539 |
Schistosoma mansoni | patched 1 | 0.0323 | 0.3714 | 0.3714 |
Echinococcus multilocularis | voltage dependent calcium channel type d subunit | 0.009 | 0.0539 | 0.0539 |
Echinococcus multilocularis | voltage dependent calcium channel | 0.009 | 0.0539 | 0.0539 |
Echinococcus granulosus | voltage dependent L type calcium channel subunit|voltage dependent calcium channel | 0.009 | 0.0539 | 0.0539 |
Echinococcus multilocularis | sterol regulatory element binding protein | 0.0323 | 0.3714 | 0.3714 |
Loa Loa (eye worm) | hypothetical protein | 0.0066 | 0.0218 | 0.0218 |
Echinococcus multilocularis | thymidylate synthase | 0.0123 | 0.0996 | 0.0996 |
Echinococcus granulosus | hydroxymethylglutaryl coenzyme A reductase | 0.0784 | 1 | 1 |
Chlamydia trachomatis | dihydrofolate reductase | 0.005 | 0 | 0.5 |
Plasmodium falciparum | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0174 | 0.1681 | 0.5 |
Brugia malayi | hypothetical protein | 0.0059 | 0.0114 | 0.0114 |
Schistosoma mansoni | niemann-pick C1 (NPC1) | 0.0323 | 0.3714 | 0.3714 |
Plasmodium vivax | bifunctional dihydrofolate reductase-thymidylate synthase, putative | 0.0174 | 0.1681 | 0.5 |
Brugia malayi | sodium-independent organic anion transporter family protein | 0.0066 | 0.0218 | 0.0218 |
Trichomonas vaginalis | 3-hydroxy-3-methylglutaryl-coenzyme A reductase, putative | 0.0368 | 0.4327 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0066 | 0.0218 | 0.0218 |
Brugia malayi | hypothetical protein | 0.0066 | 0.0218 | 0.0218 |
Echinococcus multilocularis | voltage dependent calcium channel type d subunit | 0.009 | 0.0539 | 0.0539 |
Trypanosoma brucei | dihydrofolate reductase-thymidylate synthase | 0.0174 | 0.1681 | 0.1631 |
Trypanosoma cruzi | 3-hydroxy-3-methylglutaryl-CoA reductase | 0.0784 | 1 | 1 |
Schistosoma mansoni | organic anion transporter | 0.0066 | 0.0218 | 0.0218 |
Echinococcus granulosus | organic anion transporting polypeptide 30B | 0.0066 | 0.0218 | 0.0218 |
Echinococcus multilocularis | Niemann Pick C1 protein | 0.0323 | 0.3714 | 0.3714 |
Schistosoma mansoni | hydroxymethylglutaryl-CoA reductase (NADPH) | 0.0784 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0323 | 0.3714 | 0.3714 |
Echinococcus granulosus | Niemann Pick C1 protein | 0.0323 | 0.3714 | 0.3714 |
Trichomonas vaginalis | 3-hydroxy-3-methylglutaryl-coenzyme A reductase, putative | 0.0368 | 0.4327 | 1 |
Echinococcus multilocularis | Solute carrier organic anion transporter family | 0.0066 | 0.0218 | 0.0218 |
Loa Loa (eye worm) | calcium channel | 0.009 | 0.0539 | 0.0539 |
Echinococcus granulosus | sterol regulatory element binding protein | 0.0323 | 0.3714 | 0.3714 |
Echinococcus multilocularis | voltage dependent L type calcium channel subunit | 0.009 | 0.0539 | 0.0539 |
Echinococcus granulosus | voltage dependent calcium channel type d subunit|voltage dependent calcium channel alpha 1 | 0.009 | 0.0539 | 0.0539 |
Leishmania major | 3-hydroxy-3-methylglutaryl-CoA reductase | 0.0784 | 1 | 1 |
Brugia malayi | Voltage-gated calcium channel, L-type, alpha subunit. C. elegans egl-19 ortholog | 0.009 | 0.0539 | 0.0539 |
Schistosoma mansoni | high voltage-activated calcium channel Cav2A | 0.009 | 0.0539 | 0.0539 |
Loa Loa (eye worm) | hypothetical protein | 0.0066 | 0.0218 | 0.0218 |
Echinococcus multilocularis | organic anion transporting polypeptide 30B | 0.0066 | 0.0218 | 0.0218 |
Echinococcus multilocularis | protein patched | 0.0323 | 0.3714 | 0.3714 |
Loa Loa (eye worm) | abnormal chemotaxis protein 14 | 0.0323 | 0.3714 | 0.3714 |
Echinococcus multilocularis | protein dispatched 1 | 0.0323 | 0.3714 | 0.3714 |
Loa Loa (eye worm) | hypothetical protein | 0.0066 | 0.0218 | 0.0218 |
Mycobacterium ulcerans | thymidylate synthase | 0.0123 | 0.0996 | 0.0996 |
Echinococcus granulosus | Solute carrier organic anion transporter family | 0.0066 | 0.0218 | 0.0218 |
Mycobacterium leprae | PROBABLE THYMIDYLATE SYNTHASE THYA (TS) (TSASE) | 0.0123 | 0.0996 | 1 |
Trypanosoma brucei | 3-hydroxy-3-methylglutaryl-CoA reductase, putative | 0.0784 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0066 | 0.0218 | 0.0218 |
Echinococcus granulosus | Protein patched homolog 1 | 0.0323 | 0.3714 | 0.3714 |
Loa Loa (eye worm) | hypothetical protein | 0.0066 | 0.0218 | 0.0218 |
Loa Loa (eye worm) | hypothetical protein | 0.0784 | 1 | 1 |
Schistosoma mansoni | high voltage-activated calcium channel Cav1 | 0.009 | 0.0539 | 0.0539 |
Trypanosoma cruzi | 3-hydroxy-3-methylglutaryl-CoA reductase, putative | 0.0784 | 1 | 1 |
Brugia malayi | sodium-independent organic anion transporter family protein | 0.0066 | 0.0218 | 0.0218 |
Brugia malayi | prostaglandin transporter | 0.0066 | 0.0218 | 0.0218 |
Brugia malayi | thymidylate synthase | 0.0123 | 0.0996 | 0.0996 |
Echinococcus multilocularis | voltage dependent calcium channel | 0.009 | 0.0539 | 0.0539 |
Brugia malayi | CHE-14 protein | 0.0323 | 0.3714 | 0.3714 |
Echinococcus granulosus | voltage dependent calcium channel | 0.009 | 0.0539 | 0.0539 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase, putative | 0.0059 | 0.0114 | 0.0055 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0323 | 0.3714 | 0.8543 |
Brugia malayi | sodium-independent organic anion transporter family protein | 0.0066 | 0.0218 | 0.0218 |
Schistosoma mansoni | organic anion transporter | 0.0066 | 0.0218 | 0.0218 |
Mycobacterium tuberculosis | Hypothetical protein | 0.0059 | 0.0114 | 0.1148 |
Schistosoma mansoni | voltage-gated cation channel | 0.009 | 0.0539 | 0.0539 |
Giardia lamblia | 3-hydroxy-3-methylglutaryl-coenzyme A reductase | 0.0368 | 0.4327 | 0.5 |
Toxoplasma gondii | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0174 | 0.1681 | 1 |
Loa Loa (eye worm) | sodium-independent organic anion transporter | 0.0066 | 0.0218 | 0.0218 |
Echinococcus multilocularis | voltage dependent L type calcium channel subunit | 0.009 | 0.0539 | 0.0539 |
Brugia malayi | hypothetical protein | 0.0066 | 0.0218 | 0.0218 |
Echinococcus granulosus | voltage dependent calcium channel type d subunit|voltage dependent calcium channel|voltage dependent L type calcium channel subu | 0.009 | 0.0539 | 0.0539 |
Mycobacterium tuberculosis | Probable thymidylate synthase ThyA (ts) (TSASE) | 0.0123 | 0.0996 | 1 |
Echinococcus granulosus | thymidylate synthase | 0.0123 | 0.0996 | 0.0996 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.