Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium ulcerans | F0F1 ATP synthase subunit A | 0.0246 | 1 | 1 |
Entamoeba histolytica | acetyltransferase, GNAT family | 0.0047 | 0.1095 | 0.4293 |
Toxoplasma gondii | histone lysine acetyltransferase GCN5-B | 0.0051 | 0.1287 | 1 |
Brugia malayi | Tyrosyl-DNA phosphodiesterase family protein | 0.008 | 0.2551 | 0.3742 |
Schistosoma mansoni | tyrosyl-DNA phosphodiesterase | 0.008 | 0.2551 | 0.2551 |
Trichomonas vaginalis | cat eye syndrome critical region protein 2, cscr2, putative | 0.0051 | 0.1287 | 1 |
Treponema pallidum | exodeoxyribonuclease (exoA) | 0.0023 | 0 | 0.5 |
Mycobacterium tuberculosis | Probable ATP synthase a chain AtpB (protein 6) | 0.0246 | 1 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0205 | 0.814 | 0.814 |
Trypanosoma cruzi | tyrosyl-DNA Phosphodiesterase (Tdp1), putative | 0.008 | 0.2551 | 1 |
Entamoeba histolytica | tyrosyl-DNA phosphodiesterase, putative | 0.008 | 0.2551 | 1 |
Echinococcus multilocularis | gcn5proteinral control of amino acid synthesis | 0.0175 | 0.6815 | 0.8373 |
Echinococcus granulosus | tyrosyl DNA phosphodiesterase 1 | 0.008 | 0.2551 | 0.3134 |
Loa Loa (eye worm) | acetyltransferase | 0.0175 | 0.6815 | 1 |
Echinococcus granulosus | histone acetyltransferase KAT2B | 0.017 | 0.6596 | 0.8103 |
Echinococcus granulosus | histone acetyltransferase KAT2B | 0.0051 | 0.1287 | 0.1581 |
Leishmania major | tyrosyl-DNA phosphodiesterase 1 | 0.008 | 0.2551 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0205 | 0.814 | 0.814 |
Wolbachia endosymbiont of Brugia malayi | ATP synthase F0F1 subunit A | 0.0246 | 1 | 1 |
Schistosoma mansoni | ATP synthase F0 subunit 6 | 0.0246 | 1 | 1 |
Echinococcus multilocularis | geminin | 0.0205 | 0.814 | 1 |
Brugia malayi | acetyltransferase, GNAT family protein | 0.0175 | 0.6815 | 1 |
Echinococcus granulosus | transcription factor Dp 1 | 0.0046 | 0.1048 | 0.1288 |
Echinococcus multilocularis | transcription factor Dp 1 | 0.0046 | 0.1048 | 0.1288 |
Echinococcus granulosus | geminin | 0.0205 | 0.814 | 1 |
Trichomonas vaginalis | bromodomain-containing protein, putative | 0.0051 | 0.1287 | 1 |
Plasmodium falciparum | histone acetyltransferase GCN5 | 0.0047 | 0.1095 | 1 |
Trypanosoma cruzi | tyrosyl-DNA Phosphodiesterase (Tdp1), putative | 0.008 | 0.2551 | 1 |
Plasmodium vivax | histone acetyltransferase GCN5, putative | 0.0051 | 0.1287 | 1 |
Echinococcus multilocularis | tyrosyl DNA phosphodiesterase 1 | 0.008 | 0.2551 | 0.3134 |
Schistosoma mansoni | gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 | 0.0175 | 0.6815 | 0.6815 |
Toxoplasma gondii | histone lysine acetyltransferase GCN5-A | 0.0051 | 0.1287 | 1 |
Loa Loa (eye worm) | tyrosyl-DNA phosphodiesterase | 0.008 | 0.2551 | 0.3742 |
Trypanosoma brucei | tyrosyl-DNA Phosphodiesterase (Tdp1), putative | 0.008 | 0.2551 | 1 |
Giardia lamblia | Histone acetyltransferase GCN5 | 0.0047 | 0.1095 | 1 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.