Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trichomonas vaginalis | alpha-L-fucosidase, putative | 0.3776 | 0.3761 | 0.5 |
Loa Loa (eye worm) | alpha-L-fucosidase | 0.8606 | 0.8593 | 1 |
Schistosoma mansoni | alpha-l-fucosidase | 0.8606 | 0.8593 | 1 |
Plasmodium falciparum | conserved Plasmodium protein, unknown function | 0.0026 | 0.001 | 0.5 |
Schistosoma mansoni | beta-galactosidase | 0.0085 | 0.0069 | 0.0081 |
Echinococcus granulosus | beta galactosidase | 0.0085 | 0.0069 | 0.0069 |
Schistosoma mansoni | intracisternal A-particle retropepsin (A02 family) | 0.2273 | 0.2258 | 0.2627 |
Echinococcus multilocularis | fucosidase, alpha L 1, tissue | 1.0013 | 1 | 1 |
Echinococcus multilocularis | beta galactosidase | 0.0085 | 0.0069 | 0.0069 |
Schistosoma mansoni | family A2 unassigned peptidase (A02 family) | 0.0413 | 0.0398 | 0.0463 |
Trichomonas vaginalis | alpha-L-fucosidase, putative | 0.3776 | 0.3761 | 0.5 |
Brugia malayi | Alpha-L-fucosidase family protein | 0.8606 | 0.8593 | 0.5 |
Mycobacterium ulcerans | alpha-L-fucosidase | 1.0013 | 1 | 0.5 |
Plasmodium vivax | hypothetical protein, conserved | 0.0026 | 0.001 | 0.5 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.