Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.005 | 0.0599 | 0.0374 |
Echinococcus granulosus | ryanodine receptor 44f | 0.0037 | 0.0239 | 0.0778 |
Echinococcus granulosus | adenylate cyclase 9 | 0.0136 | 0.3078 | 1 |
Brugia malayi | Adenylyl cyclase protein | 0.0136 | 0.3078 | 1 |
Trypanosoma brucei | inositol 1,4,5-trisphosphate receptor | 0.0044 | 0.0431 | 0.5 |
Echinococcus multilocularis | adenylate cyclase 9 | 0.0136 | 0.3078 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0372 | 0.9834 | 1 |
Onchocerca volvulus | 0.0136 | 0.3078 | 0.0235 | |
Loa Loa (eye worm) | hypothetical protein | 0.0051 | 0.0626 | 0.0403 |
Loa Loa (eye worm) | hypothetical protein | 0.0136 | 0.3078 | 0.2959 |
Onchocerca volvulus | Adenylate cyclase type 2 homolog | 0.0136 | 0.3078 | 0.0235 |
Schistosoma mansoni | ryanodine receptor related | 0.0052 | 0.0665 | 0.4331 |
Leishmania major | hypothetical protein, conserved | 0.003 | 0.0028 | 0.5 |
Loa Loa (eye worm) | adenylyl cyclase 3 | 0.0136 | 0.3078 | 0.2959 |
Loa Loa (eye worm) | hypothetical protein | 0.0042 | 0.0387 | 0.0154 |
Echinococcus multilocularis | ryanodine receptor 44f | 0.0037 | 0.0239 | 0.0778 |
Trypanosoma cruzi | inositol 1,4,5-trisphosphate receptor, putative | 0.0044 | 0.0431 | 0.5 |
Brugia malayi | cation channel family protein | 0.008 | 0.1456 | 0.3276 |
Schistosoma mansoni | inositol 145-trisphosphate receptor | 0.0065 | 0.103 | 1 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.