Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Entamoeba histolytica | hypothetical protein, conserved | 0.0076 | 0.1317 | 0.8779 |
Mycobacterium tuberculosis | Pantoate--beta-alanine ligase PanC (pantothenate synthetase) (pantoate activating enzyme) | 0.0422 | 0.8869 | 1 |
Entamoeba histolytica | hypothetical protein, conserved | 0.0076 | 0.1317 | 0.8779 |
Schistosoma mansoni | lamin | 0.0029 | 0.0292 | 0.0542 |
Loa Loa (eye worm) | hypothetical protein | 0.0474 | 1 | 1 |
Mycobacterium tuberculosis | Probable inosine-5'-monophosphate dehydrogenase GuaB2 (imp dehydrogenase) (inosinic acid dehydrogenase) (inosinate dehydrogenase | 0.0112 | 0.211 | 0.2291 |
Entamoeba histolytica | hypothetical protein, conserved | 0.0076 | 0.1317 | 0.8779 |
Echinococcus granulosus | lamin | 0.0029 | 0.0292 | 0.0542 |
Entamoeba histolytica | biotin--acetyl-CoA-carboxylase ligase, putative | 0.0084 | 0.1486 | 1 |
Brugia malayi | hypothetical protein | 0.0039 | 0.0502 | 0.0502 |
Loa Loa (eye worm) | GMP reductase | 0.0047 | 0.068 | 0.068 |
Echinococcus multilocularis | Protein lozenge | 0.0059 | 0.096 | 0.244 |
Toxoplasma gondii | IMP dehydrogenas | 0.0112 | 0.211 | 0.2291 |
Brugia malayi | inosine-5'-monophosphate dehydrogenase | 0.0047 | 0.068 | 0.068 |
Plasmodium vivax | biotin--[acetyl-CoA-carboxylase] synthetase, putative | 0.0084 | 0.1486 | 0.743 |
Schistosoma mansoni | lamin | 0.0029 | 0.0292 | 0.0542 |
Entamoeba histolytica | hypothetical protein, conserved | 0.0076 | 0.1317 | 0.8779 |
Brugia malayi | inosine-5'-monophosphate dehydrogenase | 0.0047 | 0.068 | 0.068 |
Entamoeba histolytica | hypothetical protein, conserved | 0.0076 | 0.1317 | 0.8779 |
Entamoeba histolytica | hypothetical protein | 0.0039 | 0.0502 | 0.2895 |
Trypanosoma cruzi | inosine-5'-monophosphate dehydrogenase, putative | 0.0112 | 0.211 | 1 |
Mycobacterium ulcerans | bifunctional protein BirA | 0.0171 | 0.3385 | 0.3744 |
Leishmania major | biotin/lipoate protein ligase-like protein | 0.0084 | 0.1486 | 0.6892 |
Mycobacterium tuberculosis | Probable inosine-5'-monophosphate dehydrogenase GuaB3 (imp dehydrogenase) (inosinic acid dehydrogenase) (inosinate dehydrogenase | 0.0059 | 0.0948 | 0.0965 |
Mycobacterium tuberculosis | Possible bifunctional protein BirA: biotin operon repressor + biotin--[acetyl-CoA-carboxylase] synthetase (biotin--protein ligas | 0.0076 | 0.1317 | 0.1386 |
Loa Loa (eye worm) | hypothetical protein | 0.0029 | 0.0292 | 0.0292 |
Entamoeba histolytica | hypothetical protein, conserved | 0.0076 | 0.1317 | 0.8779 |
Chlamydia trachomatis | biotin synthetase | 0.0084 | 0.1486 | 1 |
Mycobacterium ulcerans | inosine 5-monophosphate dehydrogenase | 0.0106 | 0.1965 | 0.2125 |
Brugia malayi | inosine-5'-monophosphate dehydrogenase family protein | 0.0112 | 0.211 | 0.211 |
Schistosoma mansoni | hypothetical protein | 0.0181 | 0.3618 | 1 |
Onchocerca volvulus | 0.0474 | 1 | 1 | |
Trypanosoma brucei | inosine-5'-monophosphate dehydrogenase | 0.0112 | 0.211 | 1 |
Trypanosoma cruzi | GMP reductase | 0.0112 | 0.211 | 1 |
Echinococcus multilocularis | biotin protein ligase | 0.0084 | 0.1486 | 0.3937 |
Echinococcus granulosus | 5'partial|biotin protein ligase | 0.0076 | 0.1317 | 0.3457 |
Schistosoma mansoni | biotin-protein ligase | 0.0084 | 0.1486 | 0.3937 |
Trypanosoma brucei | Biotin--acetyl-CoA-carboxylase ligase, putative | 0.0084 | 0.1486 | 0.6892 |
Echinococcus multilocularis | geminin | 0.0181 | 0.3618 | 1 |
Brugia malayi | intermediate filament protein | 0.0029 | 0.0292 | 0.0292 |
Brugia malayi | biotin--acetyl-CoA-carboxylase ligase family protein | 0.0084 | 0.1486 | 0.1486 |
Schistosoma mansoni | inosine-5-monophosphate dehydrogenase | 0.0112 | 0.211 | 0.5712 |
Trypanosoma cruzi | Biotin--acetyl-CoA-carboxylase ligase, putative | 0.0084 | 0.1486 | 0.6892 |
Schistosoma mansoni | lozenge | 0.0059 | 0.096 | 0.244 |
Brugia malayi | Intermediate filament tail domain containing protein | 0.0029 | 0.0292 | 0.0292 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0039 | 0.0502 | 0.114 |
Loa Loa (eye worm) | IMP dehydrogenase 1 | 0.0112 | 0.211 | 0.211 |
Trypanosoma brucei | GMP reductase | 0.0112 | 0.211 | 1 |
Echinococcus granulosus | lamin dm0 | 0.0029 | 0.0292 | 0.0542 |
Loa Loa (eye worm) | hypothetical protein | 0.0076 | 0.1317 | 0.1317 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0039 | 0.0502 | 0.114 |
Plasmodium falciparum | inosine-5'-monophosphate dehydrogenase | 0.0106 | 0.1965 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0028 | 0.0281 | 0.0281 |
Loa Loa (eye worm) | intermediate filament tail domain-containing protein | 0.0029 | 0.0292 | 0.0292 |
Wolbachia endosymbiont of Brugia malayi | IMP dehydrogenase | 0.0112 | 0.211 | 1 |
Brugia malayi | exodeoxyribonuclease III family protein | 0.002 | 0.0102 | 0.0102 |
Schistosoma mansoni | hypothetical protein | 0.0055 | 0.087 | 0.2185 |
Echinococcus multilocularis | musashi | 0.0029 | 0.0292 | 0.0542 |
Entamoeba histolytica | hypothetical protein, conserved | 0.0076 | 0.1317 | 0.8779 |
Schistosoma mansoni | hypothetical protein | 0.0181 | 0.3618 | 1 |
Mycobacterium leprae | Probable inosine-5'-monophosphate dehydrogenase GuaB3 (IMP dehydrogenase 2) (inosinic acid dehydrogenase) (inosinate dehydrogena | 0.0059 | 0.0948 | 0.0152 |
Plasmodium falciparum | biotin protein ligase, putative | 0.0084 | 0.1486 | 0.743 |
Entamoeba histolytica | hypothetical protein, conserved | 0.0076 | 0.1317 | 0.8779 |
Mycobacterium ulcerans | inosine 5'-monophosphate dehydrogenase | 0.0112 | 0.211 | 0.2291 |
Loa Loa (eye worm) | intermediate filament protein | 0.0029 | 0.0292 | 0.0292 |
Trichomonas vaginalis | ap endonuclease, putative | 0.002 | 0.0102 | 0.5 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0039 | 0.0502 | 0.114 |
Echinococcus granulosus | inosine 5' monophosphate dehydrogenase 2 | 0.0112 | 0.211 | 0.5712 |
Echinococcus multilocularis | inosine 5' monophosphate dehydrogenase 2 | 0.0112 | 0.211 | 0.5712 |
Brugia malayi | GMP reductase | 0.0047 | 0.068 | 0.068 |
Echinococcus granulosus | geminin | 0.0181 | 0.3618 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0039 | 0.0502 | 0.2895 |
Echinococcus multilocularis | N terminal of biotin protein ligase | 0.0076 | 0.1317 | 0.3457 |
Loa Loa (eye worm) | exodeoxyribonuclease III family protein | 0.002 | 0.0102 | 0.0102 |
Trypanosoma cruzi | GMP reductase | 0.0112 | 0.211 | 1 |
Trypanosoma cruzi | Biotin--acetyl-CoA-carboxylase ligase, putative | 0.0084 | 0.1486 | 0.6892 |
Mycobacterium leprae | POSSIBLE BIFUNCTIONAL PROTEIN BirA: BIOTIN OPERON REPRESSOR + BIOTIN--[ACETYL-COA-CARBOXYLASE] SYNTHETASE (BIOTIN--PROTEIN LIGAS | 0.0076 | 0.1317 | 0.0611 |
Onchocerca volvulus | Putative GMP reductase | 0.0047 | 0.068 | 0.0399 |
Echinococcus multilocularis | lamin | 0.0029 | 0.0292 | 0.0542 |
Leishmania major | guanosine monophosphate reductase | 0.0112 | 0.211 | 1 |
Mycobacterium ulcerans | pantoate--beta-alanine ligase | 0.0422 | 0.8869 | 1 |
Schistosoma mansoni | biotin-protein ligase | 0.0076 | 0.1317 | 0.3457 |
Echinococcus granulosus | N terminal of biotin protein ligase | 0.0076 | 0.1317 | 0.3457 |
Echinococcus multilocularis | lamin dm0 | 0.0029 | 0.0292 | 0.0542 |
Treponema pallidum | biotin--acetyl-CoA-carboxylase ligase | 0.0178 | 0.3554 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0474 | 1 | 1 |
Mycobacterium ulcerans | inosine 5-monophosphate dehydrogenase | 0.0053 | 0.0825 | 0.0825 |
Trypanosoma cruzi | inosine-5'-monophosphate dehydrogenase, putative | 0.0112 | 0.211 | 1 |
Trypanosoma cruzi | inosine-5'-monophosphate dehydrogenase, putative | 0.0112 | 0.211 | 1 |
Toxoplasma gondii | pantoate-beta-alanine ligase | 0.0422 | 0.8869 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0076 | 0.1317 | 0.1317 |
Giardia lamblia | Hypothetical protein | 0.0084 | 0.1486 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0039 | 0.0502 | 0.2895 |
Entamoeba histolytica | hypothetical protein | 0.0039 | 0.0502 | 0.2895 |
Wolbachia endosymbiont of Brugia malayi | biotin-(acetyl-CoA carboxylase) ligase | 0.0084 | 0.1486 | 0.6892 |
Plasmodium vivax | inosine-5'-monophosphate dehydrogenase, putative | 0.0106 | 0.1965 | 1 |
Echinococcus granulosus | intermediate filament protein | 0.0029 | 0.0292 | 0.0542 |
Schistosoma mansoni | hypothetical protein | 0.0039 | 0.0502 | 0.114 |
Plasmodium falciparum | biotin--acetyl-CoA-carboxylase, putative | 0.0084 | 0.1486 | 0.743 |
Mycobacterium leprae | Probable inosine-5'-monophosphate dehydrogenase GuaB2 (IMP dehydrogenase) (IMPDH) (IMPD) | 0.0112 | 0.211 | 0.1597 |
Schistosoma mansoni | intermediate filament proteins | 0.0029 | 0.0292 | 0.0542 |
Echinococcus multilocularis | biotin protein ligase | 0.0084 | 0.1486 | 0.3937 |
Entamoeba histolytica | hypothetical protein, conserved | 0.0076 | 0.1317 | 0.8779 |
Loa Loa (eye worm) | runx1 | 0.0059 | 0.096 | 0.096 |
Leishmania major | inosine-5-monophosphate dehydrogenase | 0.0112 | 0.211 | 1 |
Loa Loa (eye worm) | biotin protein ligase 1 | 0.0084 | 0.1486 | 0.1486 |
Mycobacterium leprae | Probable pantoate--beta-alanine ligase PanC (pantothenate synthetase) (pantoate activating enzyme) | 0.0422 | 0.8869 | 1 |
Trichomonas vaginalis | ap endonuclease, putative | 0.002 | 0.0102 | 0.5 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.