Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | acetylcholinesterase | 0.0064 | 0.1429 | 0.3846 |
Trypanosoma brucei | ingi protein (ORF1) | 0.0094 | 0.2321 | 0.1456 |
Entamoeba histolytica | deoxyuridine 5-triphosphate nucleotidohydrolase domain containing protein | 0.0044 | 0.0862 | 1 |
Schistosoma mansoni | DNA polymerase gamma | 0.0115 | 0.2958 | 0.2863 |
Wolbachia endosymbiont of Brugia malayi | ribonuclease HI | 0.0086 | 0.2104 | 1 |
Echinococcus granulosus | carboxylesterase 5A | 0.0064 | 0.1429 | 0.3846 |
Entamoeba histolytica | hypothetical protein | 0.0044 | 0.0862 | 1 |
Schistosoma mansoni | phosphoglucomutase | 0.0086 | 0.2104 | 0.1878 |
Brugia malayi | RNase H family protein | 0.0086 | 0.2104 | 0.6789 |
Loa Loa (eye worm) | carboxylesterase | 0.0064 | 0.1429 | 0.2838 |
Trichomonas vaginalis | ribonuclease H1, putative | 0.0086 | 0.2104 | 1 |
Echinococcus multilocularis | acetylcholinesterase | 0.0064 | 0.1429 | 0.3846 |
Chlamydia trachomatis | deoxyuridine 5'-triphosphate nucleotidohydrolase | 0.0044 | 0.0862 | 1 |
Entamoeba histolytica | deoxyuridine 5-triphosphate nucleotidohydrolase, mitochondrial precursor, putative | 0.0044 | 0.0862 | 1 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.0064 | 0.1429 | 0.2838 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta, putative | 0.0352 | 1 | 1 |
Toxoplasma gondii | deoxyuridine 5'-triphosphate nucleotidohydrolase, putative | 0.0044 | 0.0862 | 0.3121 |
Mycobacterium tuberculosis | Conserved hypothetical protein | 0.0185 | 0.505 | 1 |
Wolbachia endosymbiont of Brugia malayi | dUTPase | 0.0044 | 0.0862 | 0.4096 |
Echinococcus multilocularis | acetylcholinesterase | 0.0064 | 0.1429 | 0.3846 |
Plasmodium falciparum | deoxyuridine 5'-triphosphate nucleotidohydrolase | 0.0044 | 0.0862 | 0.5 |
Entamoeba histolytica | deoxyuridine 5-triphosphate nucleotidohydrolase, mitochondrial precursor, putative | 0.0044 | 0.0862 | 1 |
Brugia malayi | DNA polymerase I family protein | 0.0115 | 0.2958 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0044 | 0.0862 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0115 | 0.2958 | 1 |
Giardia lamblia | Ribonuclease H | 0.0086 | 0.2104 | 1 |
Schistosoma mansoni | phosphoglucomutase | 0.0086 | 0.2104 | 0.1878 |
Entamoeba histolytica | deoxyuridine 5-triphosphate nucleotidohydrolase domain containing protein | 0.0044 | 0.0862 | 1 |
Schistosoma mansoni | deoxyuridine 5'-triphosphate nucleotidohydrolase | 0.0044 | 0.0862 | 0.0446 |
Schistosoma mansoni | phosphoglucomutase | 0.0086 | 0.2104 | 0.1878 |
Echinococcus granulosus | DNA polymerase subunit gamma | 0.0115 | 0.2958 | 1 |
Trypanosoma cruzi | ribonuclease H1, putative | 0.0086 | 0.2104 | 0.1214 |
Loa Loa (eye worm) | dUTP diphosphatase | 0.0044 | 0.0862 | 0.0178 |
Brugia malayi | Carboxylesterase family protein | 0.0064 | 0.1429 | 0.4253 |
Entamoeba histolytica | deoxyuridine 5-triphosphate nucleotidohydrolase domain containing protein | 0.0044 | 0.0862 | 1 |
Brugia malayi | RNase H family protein | 0.0086 | 0.2104 | 0.6789 |
Trypanosoma brucei | RNA helicase, putative | 0.0323 | 0.9149 | 0.9053 |
Echinococcus multilocularis | carboxylesterase 5A | 0.0064 | 0.1429 | 0.3846 |
Toxoplasma gondii | ribonuclease HI protein | 0.0086 | 0.2104 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0064 | 0.1429 | 0.2838 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta, putative | 0.0352 | 1 | 1 |
Treponema pallidum | ribonuclease H (rnhA) | 0.0086 | 0.2104 | 1 |
Trypanosoma brucei | ribonuclease H1 | 0.0086 | 0.2104 | 0.1214 |
Echinococcus granulosus | ribonuclease H1 | 0.0086 | 0.2104 | 0.6561 |
Entamoeba histolytica | deoxyuridine 5-triphosphate nucleotidohydrolase domain containing protein | 0.0044 | 0.0862 | 1 |
Plasmodium vivax | deoxyuridine 5'-triphosphate nucleotidohydrolase, putative | 0.0044 | 0.0862 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0029 | 0.0403 | 0.4682 |
Schistosoma mansoni | hypothetical protein | 0.0323 | 0.9149 | 1 |
Echinococcus granulosus | dUTP pyrophosphatase | 0.0044 | 0.0862 | 0.156 |
Brugia malayi | dUTP diphosphatase | 0.0044 | 0.0862 | 0.2119 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta-PAK, putative | 0.0167 | 0.4491 | 0.3871 |
Trypanosoma brucei | mitochondrial DNA polymerase beta | 0.0352 | 1 | 1 |
Brugia malayi | RNase H family protein | 0.0086 | 0.2104 | 0.6789 |
Trypanosoma brucei | hypothetical protein, conserved | 0.0094 | 0.2321 | 0.1456 |
Brugia malayi | Carboxylesterase family protein | 0.0064 | 0.1429 | 0.4253 |
Leishmania major | mitochondrial DNA polymerase beta-PAK, putative | 0.0167 | 0.4491 | 0.3024 |
Echinococcus multilocularis | hypothetical protein | 0.0115 | 0.2958 | 1 |
Toxoplasma gondii | hypothetical protein | 0.0057 | 0.1229 | 0.5153 |
Onchocerca volvulus | Ribonuclease H1 homolog | 0.0086 | 0.2104 | 1 |
Mycobacterium ulcerans | hypothetical protein | 0.0185 | 0.505 | 1 |
Trypanosoma brucei | unspecified product | 0.0094 | 0.2321 | 0.1456 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta-PAK, putative | 0.006 | 0.1334 | 0.0358 |
Entamoeba histolytica | hypothetical protein | 0.0029 | 0.0403 | 0.4682 |
Echinococcus multilocularis | dUTP pyrophosphatase | 0.0044 | 0.0862 | 0.156 |
Echinococcus granulosus | acetylcholinesterase | 0.0064 | 0.1429 | 0.3846 |
Echinococcus multilocularis | ribonuclease H1 | 0.0086 | 0.2104 | 0.6561 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0064 | 0.1429 | 0.1101 |
Loa Loa (eye worm) | hypothetical protein | 0.0064 | 0.1429 | 0.2838 |
Mycobacterium leprae | PROBABLE DEOXYCYTIDINE TRIPHOSPHATE DEAMINASE DCD (DCTP DEAMINASE) | 0.0015 | 0 | 0.5 |
Trypanosoma brucei | retrotransposon hot spot protein 4 (RHS4), interrupted | 0.0094 | 0.2321 | 0.1456 |
Trypanosoma brucei | ingi protein (ORF1) | 0.0094 | 0.2321 | 0.1456 |
Trypanosoma brucei | mitochondrial DNA polymerase beta-PAK | 0.0167 | 0.4491 | 0.3871 |
Trypanosoma cruzi | ribonuclease H1, putative | 0.0086 | 0.2104 | 0.1214 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (ADMET) | Activity of human CES1 assessed as compound hydrolysis at 100 uM measured up to 60 mins by LC/TOF-MS analysis | ChEMBL. | 23386702 | |
Activity (ADMET) | Activity of human CES2 assessed as compound hydrolysis at 100 uM measured up to 60 mins by LC/TOF-MS analysis | ChEMBL. | 23386702 | |
Inhibition (ADMET) | Inhibition of human CES2 assessed as hydrolysis of 4NPA to 4NP at 1 mM by spectrophotometric analysis | ChEMBL. | 23386702 | |
Ki (ADMET) | = 468 uM | Reversible inhibition of human CES1 assessed as hydrolysis of 4NPA to 4NP | ChEMBL. | 23386702 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.