Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Escherichia coli | Dihydrofolate reductase | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Entamoeba histolytica | hypothetical protein | 0.0028 | 0.0448 | 0.5 |
Plasmodium vivax | bifunctional dihydrofolate reductase-thymidylate synthase, putative | 0.0079 | 0.397 | 0.5 |
Entamoeba histolytica | ATP-binding cassette protein, putative | 0.0028 | 0.0448 | 0.5 |
Trypanosoma brucei | dihydrofolate reductase-thymidylate synthase | 0.0079 | 0.397 | 1 |
Plasmodium falciparum | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0079 | 0.397 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0028 | 0.0448 | 0.0433 |
Trypanosoma cruzi | multidrug resistance-associated protein, putative | 0.0028 | 0.0448 | 0.1129 |
Entamoeba histolytica | multidrug resistance protein, putative | 0.0028 | 0.0448 | 0.5 |
Toxoplasma gondii | hypothetical protein | 0.0167 | 1 | 1 |
Loa Loa (eye worm) | ABC transporter transmembrane region family protein | 0.0028 | 0.0448 | 0.0433 |
Giardia lamblia | Multidrug resistance-associated protein 1 | 0.0028 | 0.0448 | 1 |
Trypanosoma cruzi | multidrug resistance-associated protein, putative | 0.0028 | 0.0448 | 0.1129 |
Loa Loa (eye worm) | hypothetical protein | 0.0028 | 0.0433 | 0.0418 |
Loa Loa (eye worm) | inward rectifying k channel family protein 1 | 0.0167 | 1 | 1 |
Entamoeba histolytica | ATP-binding cassette protein, putative | 0.0028 | 0.0448 | 0.5 |
Echinococcus multilocularis | multidrug resistance associated protein 7 | 0.0028 | 0.0448 | 0.1129 |
Entamoeba histolytica | ATP-binding cassette protein, putative | 0.0028 | 0.0448 | 0.5 |
Schistosoma mansoni | dihydrofolate reductase | 0.0079 | 0.397 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0167 | 1 | 1 |
Echinococcus granulosus | dihydrofolate reductase | 0.0079 | 0.397 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0167 | 1 | 1 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase | 0.0079 | 0.397 | 1 |
Brugia malayi | dihydrofolate reductase family protein | 0.0079 | 0.397 | 1 |
Loa Loa (eye worm) | dihydrofolate reductase | 0.0079 | 0.397 | 0.3961 |
Giardia lamblia | ABC transporter, putative | 0.0028 | 0.0448 | 1 |
Giardia lamblia | MRP-like ABC transporter | 0.0028 | 0.0448 | 1 |
Echinococcus multilocularis | dihydrofolate reductase | 0.0079 | 0.397 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0028 | 0.0448 | 0.0433 |
Mycobacterium ulcerans | dihydrofolate reductase DfrA | 0.0079 | 0.397 | 0.5 |
Mycobacterium tuberculosis | Dihydrofolate reductase DfrA (DHFR) (tetrahydrofolate dehydrogenase) | 0.0079 | 0.397 | 0.5 |
Echinococcus granulosus | multidrug resistance associated protein 1 | 0.0028 | 0.0448 | 0.1129 |
Brugia malayi | Dihydrofolate reductase | 0.0079 | 0.397 | 1 |
Echinococcus multilocularis | multidrug resistance associated protein 1 | 0.0028 | 0.0448 | 0.1129 |
Toxoplasma gondii | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0079 | 0.397 | 0.3687 |
Echinococcus granulosus | multidrug resistance associated protein 7 | 0.0028 | 0.0448 | 0.1129 |
Entamoeba histolytica | ATP-binding cassette protein, putative | 0.0028 | 0.0448 | 0.5 |
Entamoeba histolytica | ABC transporter, putative | 0.0028 | 0.0448 | 0.5 |
Leishmania major | dihydrofolate reductase-thymidylate synthase | 0.0079 | 0.397 | 1 |
Trypanosoma cruzi | multidrug resistance protein E, putative | 0.0028 | 0.0448 | 0.1129 |
Giardia lamblia | Multidrug resistance-associated protein 1 | 0.0028 | 0.0448 | 1 |
Chlamydia trachomatis | dihydrofolate reductase | 0.0079 | 0.397 | 0.5 |
Mycobacterium leprae | DIHYDROFOLATE REDUCTASE DFRA (DHFR) (TETRAHYDROFOLATE DEHYDROGENASE) | 0.0079 | 0.397 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Ki (binding) | = 6.35 | Negative logarithm of inhibition constant (-log Ki) of the compound against Dihydrofolate reductase in Escherichia coli | ChEMBL. | 8784450 |
Log 1/Ki (binding) | = 6.35 | Negative logarithm of inhibition constant (-log Ki) of the compound against Dihydrofolate reductase in Escherichia coli | ChEMBL. | 8784450 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.