Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | endoplasmic reticulum metallopeptidase 1 | 0.0327 | 0 | 0.5 |
Trypanosoma brucei | glutaminyl cyclase, putative | 0.0327 | 0 | 0.5 |
Brugia malayi | Peptidase family M28 containing protein | 0.0327 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.4583 | 0.905 | 0.905 |
Echinococcus multilocularis | n acetylated alpha linked acidic dipeptidase 2 | 0.491 | 0.9745 | 1 |
Onchocerca volvulus | Glutaminyl cyclase homolog | 0.0327 | 0 | 0.5 |
Leishmania major | hypothetical protein, conserved | 0.0327 | 0 | 0.5 |
Toxoplasma gondii | peptidase, M28 family protein | 0.0327 | 0 | 0.5 |
Brugia malayi | nicalin | 0.0327 | 0 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0327 | 0 | 0.5 |
Trypanosoma cruzi | glutaminyl cyclase, putative | 0.0327 | 0 | 0.5 |
Mycobacterium ulcerans | lipoprotein aminopeptidase LpqL | 0.0447 | 0.0255 | 1 |
Onchocerca volvulus | Fxna peptidase homolog | 0.0327 | 0 | 0.5 |
Echinococcus granulosus | endoplasmic reticulum metallopeptidase 1 | 0.0327 | 0 | 0.5 |
Schistosoma mansoni | NAALADASE L peptidase (M28 family) | 0.3218 | 0.6146 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.3337 | 0.6401 | 0.6401 |
Onchocerca volvulus | Fxna peptidase homolog | 0.0327 | 0 | 0.5 |
Trypanosoma cruzi | glutaminyl cyclase, putative | 0.0327 | 0 | 0.5 |
Brugia malayi | FXNA | 0.0327 | 0 | 0.5 |
Onchocerca volvulus | 0.0327 | 0 | 0.5 | |
Trichomonas vaginalis | conserved hypothetical protein | 0.0327 | 0 | 0.5 |
Onchocerca volvulus | Fxna peptidase homolog | 0.0327 | 0 | 0.5 |
Leishmania major | glutaminyl cyclase, putative | 0.0327 | 0 | 0.5 |
Toxoplasma gondii | hypothetical protein | 0.0327 | 0 | 0.5 |
Brugia malayi | leucyl aminopeptidase | 0.0327 | 0 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0327 | 0 | 0.5 |
Echinococcus granulosus | glutaminyl peptide cyclotransferase | 0.0327 | 0 | 0.5 |
Mycobacterium tuberculosis | Probable lipoprotein aminopeptidase LpqL | 0.0447 | 0.0255 | 1 |
Trichomonas vaginalis | Clan MH, family M28, aminopeptidase S-like metallopeptidase | 0.0327 | 0 | 0.5 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.