Detailed information for compound 2075275

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 330.468 | Formula: C19H30N4O
  • H donors: 0 H acceptors: 2 LogP: 1.79 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: CN(Cc1cc(nn1C)C1CCN(CC1)C(=O)C1CC21CCC2)C
  • InChi: 1S/C19H30N4O/c1-21(2)13-15-11-17(20-22(15)3)14-5-9-23(10-6-14)18(24)16-12-19(16)7-4-8-19/h11,14,16H,4-10,12-13H2,1-3H3
  • InChiKey: SHMLIUDXTXKMTN-UHFFFAOYSA-N  

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity

Obtained from network model

Ranking Plot


Putative Targets List


Species Potential target Raw Global Species
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0006 0.0244 1
Entamoeba histolytica cytidine deaminase, putative 0.0121 1 1
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0006 0.0244 0.0394
Echinococcus multilocularis deoxycytidylate deaminase 0.0006 0.0218 0.0218
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0006 0.0244 0.0026
Brugia malayi TAR-binding protein 0.0076 0.6203 0.6203
Brugia malayi RNA recognition motif domain containing protein 0.0076 0.6203 0.6203
Echinococcus multilocularis cytidine and deoxycytidylate deaminase 0.0006 0.0218 0.0218
Echinococcus granulosus tRNA specific adenosine deaminase 2 0.0006 0.0218 0.0218
Schistosoma mansoni tar DNA-binding protein 0.0076 0.6203 1
Brugia malayi tRNA-specific adenosine deaminase 2 0.0006 0.0218 0.0218
Echinococcus granulosus tar DNA binding protein 0.0076 0.6203 0.6203
Brugia malayi dCMP deaminase 0.0006 0.0218 0.0218
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0006 0.0244 0.0244
Toxoplasma gondii exonuclease III APE 0.0006 0.0244 0.0026
Brugia malayi RNA binding protein 0.0076 0.6203 0.6203
Mycobacterium ulcerans cytidine deaminase 0.0121 1 1
Onchocerca volvulus 0.0006 0.0218 0.0218
Echinococcus granulosus cytidine deaminase 0.0121 1 1
Giardia lamblia Cytidine deaminase 0.0121 1 1
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0006 0.0244 0.0244
Trypanosoma cruzi cytidine deaminase-like protein, putative 0.0121 1 1
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0006 0.0244 0.0026
Schistosoma mansoni tar DNA-binding protein 0.0076 0.6203 1
Schistosoma mansoni cytidine/deoxycytidylate deaminase-related 0.0006 0.0218 0.0352
Schistosoma mansoni ap endonuclease 0.0006 0.0244 0.0394
Onchocerca volvulus Putative deoxycytidylate deaminase 0.0006 0.0218 0.0218
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0006 0.0244 0.0026
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0076 0.6203 1
Toxoplasma gondii cytidine and deoxycytidylate deaminase zinc-binding region domain-containing protein 0.0121 1 1
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0006 0.0244 0.0026
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0006 0.0244 0.0026
Trichomonas vaginalis cytidine deaminase, putative 0.0121 1 1
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0006 0.0244 0.0026
Schistosoma mansoni tar DNA-binding protein 0.0076 0.6203 1
Echinococcus multilocularis cytidine deaminase 0.0121 1 1
Trichomonas vaginalis ap endonuclease, putative 0.0006 0.0244 0.0026
Onchocerca volvulus 0.0121 1 1
Leishmania major cytidine deaminase-like protein 0.0121 1 1
Schistosoma mansoni tar DNA-binding protein 0.0076 0.6203 1
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0006 0.0244 0.0026
Schistosoma mansoni cytidine/deoxycytidylate deaminase-related 0.0006 0.0218 0.0352
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0006 0.0244 1
Loa Loa (eye worm) RNA binding protein 0.0076 0.6203 1
Treponema pallidum exodeoxyribonuclease (exoA) 0.0006 0.0244 1
Trypanosoma cruzi cytidine deaminase-like protein 0.0121 1 1
Loa Loa (eye worm) hypothetical protein 0.0006 0.0218 0.0352
Trichomonas vaginalis cytidine deaminase, putative 0.0121 1 1
Echinococcus granulosus cytidine and deoxycytidylate deaminase 0.0006 0.0218 0.0218
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0006 0.0244 1
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0006 0.0244 0.0026
Loa Loa (eye worm) TAR-binding protein 0.0076 0.6203 1
Schistosoma mansoni deoxycytidylate deaminase 0.0006 0.0218 0.0352
Loa Loa (eye worm) dCMP deaminase 0.0006 0.0218 0.0352
Schistosoma mansoni tar DNA-binding protein 0.0076 0.6203 1
Trichomonas vaginalis ap endonuclease, putative 0.0006 0.0244 0.0026
Mycobacterium tuberculosis Probable cytidine deaminase Cdd (cytidine aminohydrolase) (cytidine nucleoside deaminase) 0.0121 1 1
Echinococcus multilocularis tRNA specific adenosine deaminase 2 0.0006 0.0218 0.0218
Schistosoma mansoni ap endonuclease 0.0006 0.0244 0.0394
Brugia malayi exodeoxyribonuclease III family protein 0.0006 0.0244 0.0244
Loa Loa (eye worm) tRNA-specific adenosine deaminase 2 0.0006 0.0218 0.0352
Chlamydia trachomatis bifunctional diaminohydroxyphosphoribosylaminopyrimidine deaminase/5-amino-6-(5-phosphoribosylamino) uracil reductase 0.0006 0.0218 0.5
Onchocerca volvulus 0.0121 1 1
Echinococcus multilocularis tar DNA binding protein 0.0076 0.6203 0.6203
Brugia malayi Cytidine and deoxycytidylate deaminase zinc-binding region family protein 0.0006 0.0218 0.0218
Mycobacterium leprae PROBABLE CYTIDINE DEAMINASE CDD (CYTIDINE AMINOHYDROLASE) (CYTIDINE NUCLEOSIDE DEAMINASE) 0.0121 1 1
Echinococcus granulosus deoxycytidylate deaminase 0.0006 0.0218 0.0218
Trypanosoma brucei cytidine deaminase 0.0121 1 1
Schistosoma mansoni dCTP deaminase 0.0006 0.0218 0.0352

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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