Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium tuberculosis | Dihydrofolate reductase DfrA (DHFR) (tetrahydrofolate dehydrogenase) | 0.0353 | 0.914 | 0.5 |
Onchocerca volvulus | 0.0184 | 0.2793 | 0.5 | |
Loa Loa (eye worm) | leukotriene A4 hydrolase | 0.0194 | 0.318 | 0.0538 |
Echinococcus multilocularis | dihydrofolate reductase | 0.0353 | 0.914 | 1 |
Plasmodium vivax | bifunctional dihydrofolate reductase-thymidylate synthase, putative | 0.0135 | 0.0966 | 0.5 |
Brugia malayi | Dihydrofolate reductase | 0.0353 | 0.914 | 0.8806 |
Trypanosoma brucei | dihydrofolate reductase-thymidylate synthase | 0.0135 | 0.0966 | 0.5 |
Loa Loa (eye worm) | angiotensin-converting enzyme family protein | 0.0376 | 1 | 1 |
Schistosoma mansoni | dihydrofolate reductase | 0.0353 | 0.914 | 1 |
Plasmodium falciparum | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0135 | 0.0966 | 0.5 |
Chlamydia trachomatis | dihydrofolate reductase | 0.0353 | 0.914 | 0.5 |
Echinococcus granulosus | leukotriene A 4 hydrolase | 0.0194 | 0.318 | 0.0611 |
Brugia malayi | dihydrofolate reductase family protein | 0.0353 | 0.914 | 0.8806 |
Toxoplasma gondii | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0135 | 0.0966 | 0.5 |
Loa Loa (eye worm) | dihydrofolate reductase | 0.0353 | 0.914 | 0.8806 |
Mycobacterium leprae | DIHYDROFOLATE REDUCTASE DFRA (DHFR) (TETRAHYDROFOLATE DEHYDROGENASE) | 0.0353 | 0.914 | 0.5 |
Echinococcus multilocularis | leukotriene A 4 hydrolase | 0.0194 | 0.318 | 0.0611 |
Echinococcus granulosus | dihydrofolate reductase | 0.0353 | 0.914 | 1 |
Leishmania major | dihydrofolate reductase-thymidylate synthase | 0.0135 | 0.0966 | 0.5 |
Mycobacterium ulcerans | dihydrofolate reductase DfrA | 0.0353 | 0.914 | 0.5 |
Schistosoma mansoni | leukotriene A4 hydrolase (M01 family) | 0.0194 | 0.318 | 0.348 |
Schistosoma mansoni | sodium-bile acid cotransporter related | 0.0184 | 0.2793 | 0.3056 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase | 0.0135 | 0.0966 | 0.5 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.