Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | acetyltransferase, GNAT family protein | 0.0084 | 0.3509 | 0.6668 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0011 | 0 | 0.5 |
Echinococcus multilocularis | gcn5proteinral control of amino acid synthesis | 0.0084 | 0.3509 | 0.3509 |
Brugia malayi | Pre-SET motif family protein | 0.0121 | 0.5262 | 1 |
Leishmania major | potassium channel subunit-like protein | 0.0011 | 0 | 0.5 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0017 | 0.0316 | 0.0316 |
Echinococcus granulosus | histone acetyltransferase KAT2B | 0.0082 | 0.3396 | 0.3396 |
Onchocerca volvulus | 0.0138 | 0.6059 | 1 | |
Schistosoma mansoni | hypothetical protein | 0.022 | 1 | 1 |
Leishmania major | calcium/potassium channel (CAKC), putative | 0.0011 | 0 | 0.5 |
Loa Loa (eye worm) | pre-SET domain-containing protein family protein | 0.0121 | 0.5262 | 0.5262 |
Echinococcus multilocularis | small conductance calcium activated potassium | 0.022 | 1 | 1 |
Echinococcus multilocularis | histone lysine N methyltransferase SETMAR | 0.0017 | 0.0316 | 0.0316 |
Loa Loa (eye worm) | hypothetical protein | 0.0017 | 0.0316 | 0.0316 |
Schistosoma mansoni | calcium-activated potassium channel | 0.022 | 1 | 1 |
Toxoplasma gondii | histone lysine acetyltransferase GCN5-B | 0.0025 | 0.067 | 1 |
Trichomonas vaginalis | bromodomain-containing protein, putative | 0.0025 | 0.067 | 0.1106 |
Leishmania major | ion transport protein-like protein | 0.0011 | 0 | 0.5 |
Mycobacterium ulcerans | ion transport protein | 0.0011 | 0 | 0.5 |
Echinococcus granulosus | histone lysine methyltransferase setb | 0.0017 | 0.0316 | 0.0316 |
Trypanosoma brucei | calcium-activated potassium channel, putative | 0.0011 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.022 | 1 | 1 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0011 | 0 | 0.5 |
Giardia lamblia | Histone acetyltransferase GCN5 | 0.0023 | 0.0572 | 1 |
Schistosoma mansoni | histone-lysine n-methyltransferase suv9 | 0.0017 | 0.0316 | 0.0316 |
Leishmania major | hypothetical protein, conserved | 0.0011 | 0 | 0.5 |
Schistosoma mansoni | calcium-activated potassium channel | 0.021 | 0.9487 | 0.9487 |
Onchocerca volvulus | 0.0017 | 0.0316 | 0.0521 | |
Trypanosoma cruzi | ion transport protein, putative | 0.0011 | 0 | 0.5 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0017 | 0.0316 | 0.0316 |
Trichomonas vaginalis | cat eye syndrome critical region protein 2, cscr2, putative | 0.0025 | 0.067 | 0.1106 |
Loa Loa (eye worm) | hypothetical protein | 0.0099 | 0.4217 | 0.4217 |
Plasmodium falciparum | histone acetyltransferase GCN5 | 0.0023 | 0.0572 | 1 |
Trypanosoma cruzi | calcium-activated potassium channel, putative | 0.0011 | 0 | 0.5 |
Echinococcus granulosus | 5'partial|histone lysine N methyltransferase SETDB2 | 0.0017 | 0.0285 | 0.0285 |
Loa Loa (eye worm) | hypothetical protein | 0.011 | 0.4758 | 0.4758 |
Trypanosoma brucei | calcium/potassium channel (CAKC), putative | 0.0011 | 0 | 0.5 |
Mycobacterium ulcerans | transmembrane cation transporter | 0.0011 | 0 | 0.5 |
Echinococcus granulosus | histone acetyltransferase KAT2B | 0.0025 | 0.067 | 0.067 |
Mycobacterium tuberculosis | Possible transmembrane cation transporter | 0.0011 | 0 | 0.5 |
Plasmodium vivax | histone acetyltransferase GCN5, putative | 0.0025 | 0.067 | 1 |
Trypanosoma cruzi | calcium-activated potassium channel, putative | 0.0011 | 0 | 0.5 |
Echinococcus multilocularis | histone lysine methyltransferase setb histone lysine methyltransferase eggless | 0.0017 | 0.0316 | 0.0316 |
Schistosoma mansoni | gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 | 0.0084 | 0.3509 | 0.3509 |
Plasmodium vivax | SET domain protein, putative | 0.0017 | 0.0316 | 0.4712 |
Leishmania major | hypothetical protein, conserved | 0.0011 | 0 | 0.5 |
Brugia malayi | Pre-SET motif family protein | 0.0017 | 0.0316 | 0.06 |
Trypanosoma cruzi | ion transport protein, putative | 0.0011 | 0 | 0.5 |
Entamoeba histolytica | acetyltransferase, GNAT family | 0.0023 | 0.0572 | 1 |
Trichomonas vaginalis | set domain proteins, putative | 0.0138 | 0.6059 | 1 |
Toxoplasma gondii | histone lysine acetyltransferase GCN5-A | 0.0025 | 0.067 | 1 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0017 | 0.0316 | 0.0316 |
Trypanosoma cruzi | calcium/potassium channel (CAKC), putative | 0.0011 | 0 | 0.5 |
Trypanosoma cruzi | calcium/potassium channel (CAKC), putative | 0.0011 | 0 | 0.5 |
Loa Loa (eye worm) | acetyltransferase | 0.0084 | 0.3509 | 0.3509 |
Toxoplasma gondii | histone lysine methyltransferase SET/SUV39 | 0.0017 | 0.0316 | 0.4712 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.