TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 453.476 | Formula: C18H26F3N3O5S
H donors: 1 H acceptors: 5 LogP: 2.27 Rotable bonds: 5
Rule of 5 violations (Lipinski): 1
SMILES: OC(=O)C(F)(F)F.CCCS(=O)(=O)N1CCOCC2(C1)CCN(C2)c1ccccn1
InChi: 1S/C16H25N3O3S.C2HF3O2/c1-2-11-23(20,21)19-9-10-22-14-16(13-19)6-8-18(12-16)15-5-3-4-7-17-15;3-2(4,5)1(6)7/h3-5,7H,2,6,8-14H2,1H3;(H,6,7)
InChiKey: SPIRSLQZUSFCRY-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0255	0.0262
Leishmania major	protein kinase, putative	0.002	0.0401	0.0536
Trypanosoma cruzi	STE/STE11 serine/threonine-protein kinase, putative	0.002	0.0401	0.0536
Schistosoma mansoni	coup transcription factor	0.0035	0.0969	0.0969
Brugia malayi	hypothetical protein	0.0018	0.0331	0.0306
Echinococcus granulosus	nuclear receptor nhr 48	0.0016	0.0255	0.0255
Brugia malayi	Nuclear hormone receptor family member nhr-1	0.0035	0.0969	0.0964
Echinococcus granulosus	NADP dependent isocitrate dehydrogenase	0.0011	0.0034	0.0034
Loa Loa (eye worm)	nuclear receptor NHR-67	0.0016	0.0255	0.0262
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.0024	0.0567	0.0567
Schistosoma mansoni	DEAD box ATP-dependent RNA helicase	0.0187	0.6871	0.6871
Loa Loa (eye worm)	DR-78	0.0016	0.0255	0.0262
Loa Loa (eye worm)	6-phosphofructokinase	0.0098	0.3409	0.3503
Trichomonas vaginalis	DEAD box ATP-dependent RNA helicase, putative	0.0187	0.6871	1
Trichomonas vaginalis	phosphofructokinase, putative	0.0026	0.0642	0.0372
Echinococcus multilocularis	FTZ F1 alpha	0.0035	0.0969	0.0969
Echinococcus granulosus	FTZ F1 nuclear receptor protein	0.0035	0.0969	0.0969
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0255	0.0262
Echinococcus multilocularis	thyroid hormone receptor alpha	0.0035	0.0969	0.0969
Schistosoma mansoni	DEAD box ATP-dependent RNA helicase	0.0187	0.6871	0.6871
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0969	0.0996
Entamoeba histolytica	pyrophosphate-dependent phosphofructokinase	0.0026	0.0642	0.0119
Echinococcus multilocularis	NADP dependent isocitrate dehydrogenase	0.0011	0.0034	0.0034
Brugia malayi	orphan nuclear receptor NR2E1	0.0016	0.0255	0.0227
Echinococcus granulosus	nuclear receptor subfamily 4 group A	0.0016	0.0255	0.0255
Echinococcus multilocularis	transfer RNA-Lys	0.0057	0.1849	0.1849
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0018	0.0331	0.0331
Echinococcus multilocularis	isocitrate dehydrogenase 2 (NADP+)	0.0011	0.0034	0.0034
Schistosoma mansoni	nuclear receptor nhr-48	0.0016	0.0255	0.0255
Toxoplasma gondii	6-phosphofructokinase	0.0026	0.0642	0.0888
Brugia malayi	PAS domain containing protein	0.0078	0.2632	0.2679
Echinococcus granulosus	aryl hydrocarbon receptor	0.002	0.0401	0.0401
Mycobacterium tuberculosis	Probable cold-shock DeaD-box protein A homolog DeaD (ATP-dependent RNA helicase dead homolog)	0.0187	0.6871	1
Plasmodium falciparum	ATP-dependent 6-phosphofructokinase	0.0026	0.0642	0.0888
Loa Loa (eye worm)	hypothetical protein	0.0187	0.6871	0.706
Trichomonas vaginalis	6-phosphofructokinase, putative	0.0026	0.0642	0.0372
Brugia malayi	6-phosphofructokinase	0.0098	0.3409	0.348
Schistosoma mansoni	zinc finger protein	0.0016	0.0255	0.0255
Trypanosoma cruzi	STE group serine/threonine-protein kinase, putative	0.002	0.0401	0.0536
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-1	0.0035	0.0969	0.0996
Echinococcus granulosus	eukaryotic initiation factor 4A	0.0187	0.6871	0.6871
Trypanosoma cruzi	Eukaryotic initiation factor 4A-1	0.0187	0.6871	1
Echinococcus multilocularis	6 phosphofructokinase	0.0098	0.3409	0.3409
Echinococcus granulosus	hepatocyte nuclear factor 4 alpha	0.0035	0.0969	0.0969
Loa Loa (eye worm)	steroid hormone receptor	0.0035	0.0969	0.0996
Plasmodium vivax	6-phosphofructokinase, putative	0.0026	0.0642	0.0888
Brugia malayi	phosphofructokinase	0.0098	0.3409	0.348
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0035	0.0969	0.0969
Trypanosoma cruzi	STE group serine/threonine-protein kinase, putative	0.002	0.0401	0.0536
Brugia malayi	Nuclear hormone receptor-like 1	0.0018	0.0331	0.0306
Brugia malayi	Nuclear hormone receptor-like 1	0.0018	0.0331	0.0306
Schistosoma mansoni	nuclear hormone receptor superfamily protein-related	0.0016	0.0255	0.0255
Echinococcus multilocularis	Nuclear hormone receptor HR96	0.0016	0.0255	0.0255
Onchocerca volvulus	Protein ultraspiracle homolog	0.0035	0.0969	0.1079
Brugia malayi	Nuclear hormone receptor family member nhr-31	0.0035	0.0969	0.0964
Brugia malayi	nuclear receptor RXR	0.0018	0.0331	0.0306
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0255	0.0262
Trichomonas vaginalis	phosphofructokinase, putative	0.0026	0.0642	0.0372
Brugia malayi	nuclear hormone receptor family member nhr-6	0.0016	0.0255	0.0227
Echinococcus granulosus	thyroid hormone receptor alpha	0.0016	0.0255	0.0255
Schistosoma mansoni	6-phosphofructokinase	0.0098	0.3409	0.3409
Schistosoma mansoni	RAR-like nuclear receptor	0.0035	0.0969	0.0969
Echinococcus granulosus	retinoic acid receptor rxr beta a	0.0035	0.0969	0.0969
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-40	0.0035	0.0969	0.0996
Plasmodium falciparum	eukaryotic initiation factor 4A	0.0187	0.6871	1
Chlamydia trachomatis	fructose-6-phosphate phosphotransferase	0.0026	0.0642	1
Mycobacterium leprae	PROBABLE 6-PHOSPHOFRUCTOKINASE PFKA (PHOSPHOHEXOKINASE) (PHOSPHOFRUCTOKINASE)	0.0098	0.3409	1
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0016	0.0255	0.0255
Schistosoma mansoni	transcription factor LCR-F1	0.0024	0.0567	0.0567
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0255	0.0262
Brugia malayi	hypothetical protein	0.0024	0.0567	0.0549
Echinococcus multilocularis	geminin	0.0267	1	1
Trypanosoma cruzi	ATP-dependent 6-phosphofructokinase, glycosomal	0.0098	0.3409	0.4936
Trichomonas vaginalis	DEAD box ATP-dependent RNA helicase, putative	0.0187	0.6871	1
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0035	0.0969	0.0964
Loa Loa (eye worm)	nuclear hormone receptor-like 1	0.0018	0.0331	0.034
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0331	0.034
Schistosoma mansoni	retinoic acid receptor RXR	0.0035	0.0969	0.0969
Brugia malayi	Steroid receptor seven-up type 2	0.0035	0.0969	0.0964
Echinococcus granulosus	Nuclear hormone receptor family member nhr 41	0.0035	0.0969	0.0969
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0035	0.0969	0.0964
Brugia malayi	nuclear hormone receptor	0.0016	0.0255	0.0227
Brugia malayi	hypoxia-induced factor 1	0.024	0.8948	0.9192
Mycobacterium tuberculosis	Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase)	0.0098	0.3409	0.4936
Brugia malayi	hypothetical protein	0.026	0.9731	1
Brugia malayi	Nuclear hormone receptor E75	0.0016	0.0255	0.0227
Echinococcus multilocularis	Nuclear hormone receptor HR96	0.0016	0.0255	0.0255
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0035	0.0969	0.0969
Loa Loa (eye worm)	isocitrate dehydrogenase	0.0011	0.0034	0.0035
Onchocerca volvulus		0.0162	0.5907	0.8544
Treponema pallidum	ATP-dependent RNA helicase	0.0187	0.6871	1
Schistosoma mansoni	thyroid hormone receptor	0.0035	0.0969	0.0969
Echinococcus multilocularis	hepatocyte nuclear factor 4 alpha	0.0035	0.0969	0.0969
Brugia malayi	ecdysteroid receptor	0.0035	0.0969	0.0964
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0035	0.0969	0.0964
Brugia malayi	ecdysone receptor	0.0016	0.0255	0.0227
Brugia malayi	nuclear receptor subfamily 1, group D, member 1, putative	0.0016	0.0255	0.0227
Trichomonas vaginalis	phosphofructokinase, putative	0.0026	0.0642	0.0372
Loa Loa (eye worm)	phosphofructokinase	0.0098	0.3409	0.3503
Brugia malayi	tailless protein	0.0016	0.0255	0.0227
Plasmodium vivax	6-phosphofructokinase, putative	0.0026	0.0642	0.0888
Entamoeba histolytica	phosphofructokinase, putative	0.0098	0.3409	0.4508
Schistosoma mansoni	nuclear hormone receptor nor-1/nor-2	0.0035	0.0969	0.0969
Echinococcus multilocularis	NADP dependent isocitrate dehydrogenase	0.0011	0.0034	0.0034
Onchocerca volvulus	Eukaryotic initiation factor 4A homolog	0.0187	0.6871	1
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0035	0.0969	0.0969
Echinococcus multilocularis	nuclear receptor subfamily 4 group A	0.0016	0.0255	0.0255
Schistosoma mansoni	nuclear hormone receptor	0.0016	0.0255	0.0255
Brugia malayi	eukaryotic initiation factor 4A	0.0187	0.6871	0.705
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0035	0.0969	0.0964
Loa Loa (eye worm)	nuclear receptor nhr-7B	0.0016	0.0255	0.0262
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0969	0.0996
Brugia malayi	Nuclear hormone receptor E75	0.0016	0.0255	0.0227
Brugia malayi	bHLH-PAS transcription factor	0.0057	0.1849	0.1871
Plasmodium falciparum	ATP-dependent 6-phosphofructokinase	0.0026	0.0642	0.0888
Trypanosoma cruzi	STE/STE11 serine/threonine-protein kinase, putative	0.002	0.0401	0.0536
Schistosoma mansoni	nuclear hormone receptor	0.0016	0.0255	0.0255
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0969	0.0996
Leishmania major	eukaryotic initiation factor 4a, putative	0.0187	0.6871	1
Schistosoma mansoni	nuclear receptor	0.0016	0.0255	0.0255
Brugia malayi	hypothetical protein	0.0016	0.0255	0.0227
Echinococcus granulosus	FTZ F1 alpha	0.0035	0.0969	0.0969
Leishmania major	ATP-dependent phosphofructokinase	0.0098	0.3409	0.4936
Trichomonas vaginalis	DEAD box ATP-dependent RNA helicase, putative	0.0187	0.6871	1
Toxoplasma gondii	phosphofructokinase domain-containing protein	0.0026	0.0642	0.0888
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0331	0.034
Giardia lamblia	Translation initiation factor eIF-4A, putative	0.0187	0.6871	1
Schistosoma mansoni	FTZ-F1 nuclear receptor-like protein	0.0035	0.0969	0.0969
Trichomonas vaginalis	phosphofructokinase, putative	0.0098	0.3409	0.4649
Trypanosoma cruzi	Eukaryotic initiation factor 4A-1	0.0187	0.6871	1
Onchocerca volvulus		0.002	0.0401	0.0221
Loa Loa (eye worm)	aryl Hydrocarbon receptor Associated protein family member	0.002	0.0401	0.0412
Brugia malayi	conserved hypotetical protein	0.0016	0.0255	0.0227
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0969	0.0996
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-49	0.0035	0.0969	0.0996
Schistosoma mansoni	nuclear receptor	0.0016	0.0255	0.0255
Brugia malayi	nuclear receptor NHR-67	0.0016	0.0255	0.0227
Echinococcus granulosus	Nuclear hormone receptor HR96	0.0016	0.0255	0.0255
Schistosoma mansoni	nuclear hormone receptor	0.0035	0.0969	0.0969
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0331	0.034
Schistosoma mansoni	photoreceptor-specific nuclear receptor related	0.0035	0.0969	0.0969
Loa Loa (eye worm)	hypothetical protein	0.026	0.9731	1
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0255	0.0262
Echinococcus multilocularis	retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha	0.0016	0.0255	0.0255
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0255	0.0262
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0255	0.0262
Trichomonas vaginalis	phosphofructokinase, putative	0.0098	0.3409	0.4649
Echinococcus granulosus	nuclear factor of activated T cells 5	0.015	0.5448	0.5448
Echinococcus multilocularis	eukaryotic initiation factor 4A III	0.0187	0.6871	0.6871
Entamoeba histolytica	phosphofructokinase, putative	0.0098	0.3409	0.4508
Trichomonas vaginalis	phosphofructokinase, putative	0.0026	0.0642	0.0372
Brugia malayi	Pax transcription factor protein 2	0.0162	0.5907	0.6056
Echinococcus granulosus	Nuclear hormone receptor HR96	0.0016	0.0255	0.0255
Schistosoma mansoni	hypothetical protein	0.0267	1	1
Brugia malayi	Nuclear hormone receptor family member nhr-49	0.0035	0.0969	0.0964
Leishmania major	PAS-domain containing phosphoglycerate kinase, putative	0.002	0.0401	0.0536
Brugia malayi	nuclear hormone receptor	0.0035	0.0969	0.0964
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-14	0.0035	0.0969	0.0996
Trichomonas vaginalis	phosphofructokinase, putative	0.0026	0.0642	0.0372
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-31	0.0035	0.0969	0.0996
Trichomonas vaginalis	phosphofructokinase, putative	0.0026	0.0642	0.0372
Loa Loa (eye worm)	6-phosphofructokinase	0.0098	0.3409	0.3503
Trichomonas vaginalis	phosphofructokinase, putative	0.0098	0.3409	0.4649
Loa Loa (eye worm)	pax transcription factor protein 2	0.0162	0.5907	0.607
Echinococcus granulosus	eukaryotic initiation factor 4A III	0.0187	0.6871	0.6871
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0969	0.0996
Schistosoma mansoni	aryl hydrocarbon receptor	0.0078	0.2632	0.2632
Echinococcus multilocularis	nuclear receptor nhr 48	0.0016	0.0255	0.0255
Onchocerca volvulus		0.0057	0.1849	0.2409
Brugia malayi	nuclear hormone receptor family member odr-7	0.0016	0.0255	0.0227
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-41	0.0035	0.0969	0.0996
Brugia malayi	nuclear receptor NHR-88	0.0016	0.0255	0.0227
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0969	0.0996
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.0024	0.0567	0.0567
Brugia malayi	Nuclear hormone receptor family member nhr-40	0.0035	0.0969	0.0964
Toxoplasma gondii	phosphofructokinase PFKII	0.0026	0.0642	0.0888
Echinococcus granulosus	Aryl hydrocarbon receptor nuclear	0.002	0.0401	0.0401
Leishmania major	protein kinase, putative	0.002	0.0401	0.0536
Echinococcus granulosus	single minded 2	0.0057	0.1849	0.1849
Leishmania major	eukaryotic initiation factor 4a, putative	0.0187	0.6871	1
Onchocerca volvulus	Bile acid receptor homolog	0.0035	0.0969	0.1079
Echinococcus multilocularis	COUP TF:Svp nuclear hormone receptor	0.0035	0.0969	0.0969
Echinococcus multilocularis	Nuclear hormone receptor family member nhr 41	0.0035	0.0969	0.0969
Echinococcus multilocularis	eukaryotic initiation factor 4A	0.0187	0.6871	0.6871
Entamoeba histolytica	phosphofructokinase, putative	0.0098	0.3409	0.4508
Echinococcus multilocularis	nuclear factor of activated T cells 5	0.015	0.5448	0.5448
Brugia malayi	Nuclear hormone receptor-like 1	0.0035	0.0969	0.0964
Schistosoma mansoni	hypothetical protein	0.0267	1	1
Onchocerca volvulus	Steroid hormone receptor family member cnr14 homolog	0.0035	0.0969	0.1079
Trypanosoma brucei	Eukaryotic initiation factor 4A-1	0.0187	0.6871	1
Brugia malayi	nuclear receptor NHR-88	0.0035	0.0969	0.0964
Echinococcus granulosus	6 phosphofructokinase	0.0098	0.3409	0.3409
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0016	0.0255	0.0255
Brugia malayi	Nuclear hormone receptor family member nhr-41	0.0035	0.0969	0.0964
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0331	0.034
Brugia malayi	nuclear receptor RXR	0.0016	0.0255	0.0227
Echinococcus granulosus	ecdysone induced protein 78C	0.0035	0.0969	0.0969
Mycobacterium ulcerans	6-phosphofructokinase	0.0098	0.3409	1
Echinococcus multilocularis	ecdysone induced protein 78C	0.0035	0.0969	0.0969
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0035	0.0969	0.0969
Schistosoma mansoni	hepatocyte nuclear factor 4-alpha (hnf-4-alpha)	0.0016	0.0255	0.0255
Brugia malayi	photoreceptor-specific nuclear receptor	0.0035	0.0969	0.0964
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0255	0.0262
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0969	0.0996
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0255	0.0262
Loa Loa (eye worm)	hypoxia-induced factor 1	0.024	0.8948	0.9195
Onchocerca volvulus		0.0035	0.0969	0.1079
Echinococcus granulosus	COUP TF:Svp nuclear hormone receptor	0.0035	0.0969	0.0969
Trichomonas vaginalis	phosphofructokinase, putative	0.0098	0.3409	0.4649
Toxoplasma gondii	eukaryotic initiation factor-4A, putative	0.0187	0.6871	1
Echinococcus multilocularis	aryl hydrocarbon receptor	0.002	0.0401	0.0401
Loa Loa (eye worm)	nuclear hormone receptor	0.0016	0.0255	0.0262
Trypanosoma cruzi	PAS-domain containing phosphoglycerate kinase, putative	0.002	0.0401	0.0536
Schistosoma mansoni	NADP-specific isocitrate dehydrogenase	0.0011	0.0034	0.0034
Brugia malayi	hypothetical protein	0.0018	0.0331	0.0306
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0255	0.0262
Chlamydia trachomatis	fructose-6-phosphate phosphotransferase	0.0026	0.0642	1
Schistosoma mansoni	nuclear receptor 2DBD-gamma	0.0035	0.0969	0.0969
Schistosoma mansoni	6-phosphofructokinase	0.0098	0.3409	0.3409
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0035	0.0969	0.0964
Echinococcus multilocularis	isocitrate dehydrogenase	0.0011	0.0034	0.0034
Echinococcus granulosus	nuclear receptor subfamily 1 group D	0.0018	0.0331	0.0331
Brugia malayi	6-phosphofructokinase	0.0098	0.3409	0.348
Treponema pallidum	diphosphate--fructose-6-phosphate 1-phosphotransferase	0.0098	0.3409	0.4442
Loa Loa (eye worm)	nuclear Hormone Receptor family member	0.0035	0.0969	0.0996
Entamoeba histolytica	DEAD/DEAH box helicase, putative	0.0187	0.6871	1
Echinococcus multilocularis	nuclear receptor subfamily 1 group D	0.0018	0.0331	0.0331
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0331	0.034
Schistosoma mansoni	steroid hormone receptor ad4bp	0.0035	0.0969	0.0969
Schistosoma mansoni	hypothetical protein	0.0024	0.0567	0.0567
Echinococcus multilocularis	FTZ F1 nuclear receptor protein	0.0035	0.0969	0.0969
Trypanosoma brucei	ATP-dependent 6-phosphofructokinase, glycosomal	0.0098	0.3409	0.4936
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0255	0.0262
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0255	0.0262
Schistosoma mansoni	Tr4/Tr2 (homologue)	0.0035	0.0969	0.0969
Plasmodium vivax	RNA helicase-1, putative	0.0187	0.6871	1
Brugia malayi	Nuclear hormone receptor family member nhr-14	0.0035	0.0969	0.0964
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0035	0.0969	0.0969
Brugia malayi	steroid hormone receptor	0.0035	0.0969	0.0964
Brugia malayi	Nuclear hormone receptor family member nhr-3	0.0035	0.0969	0.0964
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0035	0.0969	0.0964
Schistosoma mansoni	ecdysone-induced protein 78c (dr-78)	0.0018	0.0331	0.0331
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0969	0.0996
Loa Loa (eye worm)	hypothetical protein	0.002	0.0401	0.0412
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0255	0.0262
Brugia malayi	hypothetical protein	0.0016	0.0255	0.0227
Schistosoma mansoni	single-minded	0.0078	0.2632	0.2632
Echinococcus multilocularis	Aryl hydrocarbon receptor nuclear	0.002	0.0401	0.0401
Echinococcus multilocularis	NADP dependent isocitrate dehydrogenase	0.0011	0.0034	0.0034
Schistosoma mansoni	thyroid hormone receptor	0.0035	0.0969	0.0969
Trypanosoma cruzi	PAS-domain containing phosphoglycerate kinase, putative	0.002	0.0401	0.0536

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL3501034

Bibliographic References

No literature references available for this target.

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Detailed information for compound 2077967