Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | geminin | 0.0205 | 0.7118 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0205 | 0.7118 | 0.7118 |
Mycobacterium ulcerans | F0F1 ATP synthase subunit A | 0.0262 | 1 | 0.5 |
Mycobacterium tuberculosis | Probable ATP synthase a chain AtpB (protein 6) | 0.0262 | 1 | 0.5 |
Echinococcus multilocularis | geminin | 0.0205 | 0.7118 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0205 | 0.7118 | 0.7118 |
Brugia malayi | hypothetical protein | 0.0148 | 0.428 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0148 | 0.428 | 0.5 |
Schistosoma mansoni | ATP synthase F0 subunit 6 | 0.0262 | 1 | 1 |
Onchocerca volvulus | Huntingtin homolog | 0.0148 | 0.428 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0148 | 0.428 | 0.5 |
Onchocerca volvulus | Huntingtin homolog | 0.0148 | 0.428 | 0.5 |
Wolbachia endosymbiont of Brugia malayi | ATP synthase F0F1 subunit A | 0.0262 | 1 | 0.5 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.