Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | S adenosylmethionine decarboxylase proenzyme | 0.0092 | 0.1156 | 0.3841 |
Schistosoma mansoni | hypothetical protein | 0.0188 | 0.3009 | 1 |
Schistosoma mansoni | jumonji/arid domain-containing protein | 0.0039 | 0.0132 | 0.0437 |
Trypanosoma cruzi | S-adenosylmethionine decarboxylase proenzyme, putative | 0.0092 | 0.1156 | 1 |
Echinococcus granulosus | histone lysine methyltransferase setb | 0.0069 | 0.0714 | 0.2372 |
Brugia malayi | Pre-SET motif family protein | 0.0483 | 0.871 | 1 |
Echinococcus granulosus | geminin | 0.0188 | 0.3009 | 1 |
Schistosoma mansoni | jumonji/arid domain-containing protein | 0.0039 | 0.0132 | 0.0437 |
Schistosoma mansoni | protein arginine N-methyltransferase 1 | 0.0037 | 0.0089 | 0.0295 |
Brugia malayi | NNMT/PNMT/TEMT family protein | 0.0334 | 0.5836 | 0.6701 |
Plasmodium falciparum | protein arginine N-methyltransferase 1 | 0.0037 | 0.0089 | 0.3667 |
Echinococcus multilocularis | histone lysine methyltransferase setb histone lysine methyltransferase eggless | 0.0069 | 0.0714 | 0.2372 |
Leishmania major | S-adenosylmethionine decarboxylase | 0.0092 | 0.1156 | 1 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0069 | 0.0714 | 0.2372 |
Loa Loa (eye worm) | pre-SET domain-containing protein family protein | 0.0483 | 0.871 | 1 |
Brugia malayi | hypothetical protein | 0.0058 | 0.0491 | 0.0564 |
Schistosoma mansoni | histone-lysine n-methyltransferase suv9 | 0.0069 | 0.0714 | 0.2372 |
Loa Loa (eye worm) | hypothetical protein | 0.0055 | 0.0447 | 0.0513 |
Loa Loa (eye worm) | hypothetical protein | 0.0334 | 0.5836 | 0.6701 |
Brugia malayi | Pre-SET motif family protein | 0.0069 | 0.0714 | 0.0819 |
Schistosoma mansoni | protein arginine N-methyltransferase 1 | 0.0037 | 0.0089 | 0.0295 |
Loa Loa (eye worm) | hypothetical protein | 0.0069 | 0.0714 | 0.0819 |
Schistosoma mansoni | hypothetical protein | 0.0188 | 0.3009 | 1 |
Trypanosoma brucei | S-adenosylmethionine decarboxylase | 0.0092 | 0.1156 | 1 |
Loa Loa (eye worm) | S-adenosylmethionine decarboxylase proenzyme | 0.0092 | 0.1156 | 0.1327 |
Schistosoma mansoni | hypothetical protein | 0.0063 | 0.0585 | 0.1946 |
Echinococcus granulosus | jumonji domain containing protein | 0.0045 | 0.0245 | 0.0814 |
Toxoplasma gondii | histone lysine methyltransferase SET/SUV39 | 0.0069 | 0.0714 | 1 |
Plasmodium vivax | S-adenosylmethionine decarboxylase-ornithine decarboxylase, putative | 0.0045 | 0.0242 | 0.3392 |
Loa Loa (eye worm) | jmjC domain-containing protein | 0.0039 | 0.0132 | 0.0151 |
Trypanosoma brucei | S-adenosylmethionine decarboxylase | 0.0092 | 0.1156 | 1 |
Echinococcus multilocularis | lysine specific demethylase 5A | 0.0039 | 0.0132 | 0.0437 |
Loa Loa (eye worm) | NNMT/PNMT/TEMT family protein | 0.0334 | 0.5836 | 0.6701 |
Schistosoma mansoni | jumonji domain containing protein | 0.0084 | 0.1002 | 0.3329 |
Brugia malayi | jmjC domain containing protein | 0.0039 | 0.0132 | 0.0151 |
Brugia malayi | jmjC domain containing protein | 0.0106 | 0.1423 | 0.1633 |
Giardia lamblia | PHD finger protein 15 | 0.0032 | 0 | 0.5 |
Schistosoma mansoni | protein arginine N-methyltransferase 1 | 0.0037 | 0.0089 | 0.0295 |
Echinococcus granulosus | protein arginine methyltransferase | 0.0037 | 0.0089 | 0.0295 |
Loa Loa (eye worm) | hypothetical protein | 0.0058 | 0.0491 | 0.0564 |
Echinococcus multilocularis | protein arginine N methyltransferase 8 | 0.0037 | 0.0089 | 0.0295 |
Loa Loa (eye worm) | hypothetical protein | 0.0334 | 0.5836 | 0.6701 |
Echinococcus multilocularis | protein arginine methyltransferase | 0.0037 | 0.0089 | 0.0295 |
Loa Loa (eye worm) | jmjC domain-containing protein | 0.0067 | 0.0666 | 0.0764 |
Trichomonas vaginalis | set domain proteins, putative | 0.055 | 1 | 1 |
Echinococcus granulosus | lysine specific demethylase 5A | 0.0039 | 0.0132 | 0.0437 |
Echinococcus granulosus | 5'partial|histone lysine N methyltransferase SETDB2 | 0.0067 | 0.0665 | 0.2208 |
Trypanosoma cruzi | S-adenosylmethionine decarboxylase proenzyme, putative | 0.0092 | 0.1156 | 1 |
Onchocerca volvulus | 0.0069 | 0.0714 | 0.0714 | |
Brugia malayi | S-adenosylmethionine decarboxylase proenzyme | 0.0092 | 0.1156 | 0.1327 |
Entamoeba histolytica | arginine N-methyltransferase protein, putative | 0.0058 | 0.0491 | 0.5 |
Echinococcus granulosus | protein arginine N methyltransferase 8 | 0.0037 | 0.0089 | 0.0295 |
Trypanosoma brucei | S-adenosylmethionine decarboxylase proenzyme, putative | 0.0092 | 0.1156 | 1 |
Echinococcus multilocularis | jumonji domain containing protein | 0.0045 | 0.0245 | 0.0814 |
Echinococcus multilocularis | geminin | 0.0188 | 0.3009 | 1 |
Echinococcus granulosus | S adenosylmethionine decarboxylase proenzyme | 0.0092 | 0.1156 | 0.3841 |
Plasmodium falciparum | S-adenosylmethionine decarboxylase/ornithine decarboxylase | 0.0045 | 0.0242 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0058 | 0.0491 | 0.5 |
Toxoplasma gondii | histone arginine methyltransferase PRMT1 | 0.0037 | 0.0089 | 0.1244 |
Echinococcus multilocularis | histone lysine N methyltransferase SETMAR | 0.0069 | 0.0714 | 0.2372 |
Echinococcus granulosus | Transcription factor JmjC domain containing protein | 0.0106 | 0.1423 | 0.4728 |
Plasmodium vivax | protein arginine N-methyltransferase 1, putative | 0.0037 | 0.0089 | 0.1244 |
Plasmodium vivax | SET domain protein, putative | 0.0069 | 0.0714 | 1 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0069 | 0.0714 | 0.2372 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0069 | 0.0714 | 0.2372 |
Echinococcus multilocularis | Transcription factor, JmjC domain containing protein | 0.0106 | 0.1423 | 0.4728 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.