Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Staphylococcus aureus | Isoleucyl-tRNA synthetase | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0743 | 0.8336 | 0.8328 |
Treponema pallidum | isoleucyl-tRNA synthetase | 0.0032 | 0.013 | 0.5 |
Schistosoma mansoni | vesicular acetylcholine transporter | 0.0887 | 1 | 1 |
Loa Loa (eye worm) | vesicular acetylcholine transporter unc-17 | 0.0887 | 1 | 1 |
Trypanosoma cruzi | C-8 sterol isomerase, putative | 0.0743 | 0.8336 | 1 |
Echinococcus granulosus | isoleucyl tRNA synthetase, cytoplasmic | 0.0032 | 0.013 | 0.0079 |
Plasmodium falciparum | isoleucine--tRNA ligase, putative | 0.0123 | 0.1187 | 1 |
Onchocerca volvulus | Vesicular acetylcholine transporter homolog | 0.0887 | 1 | 1 |
Trypanosoma brucei | C-8 sterol isomerase, putative | 0.0743 | 0.8336 | 1 |
Mycobacterium ulcerans | formamidopyrimidine-DNA glycosylase | 0.0112 | 0.1057 | 1 |
Echinococcus multilocularis | isoleucyl tRNA synthetase, cytoplasmic | 0.0032 | 0.013 | 0.0079 |
Entamoeba histolytica | isoleucyl-tRNA synthetase, putative | 0.0032 | 0.013 | 0.5 |
Echinococcus multilocularis | vesicular acetylcholine transporter | 0.0887 | 1 | 1 |
Plasmodium vivax | isoleucine--tRNA ligase, putative | 0.0032 | 0.013 | 0.5 |
Loa Loa (eye worm) | isoleucyl-tRNA synthetase | 0.0032 | 0.013 | 0.0079 |
Brugia malayi | ERG2 and Sigma1 receptor like protein | 0.0743 | 0.8336 | 0.8314 |
Echinococcus granulosus | vesicular acetylcholine transporter | 0.0887 | 1 | 1 |
Mycobacterium tuberculosis | Possible DNA glycosylase | 0.0112 | 0.1057 | 1 |
Mycobacterium ulcerans | formamidopyrimidine-DNA glycosylase | 0.0112 | 0.1057 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0032 | 0.013 | 0.0079 |
Chlamydia trachomatis | isoleucine--tRNA ligase | 0.0032 | 0.013 | 0.5 |
Toxoplasma gondii | isoleucyl-tRNA synthetase family protein | 0.0032 | 0.013 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.038 | 0.4145 | 0.4114 |
Leishmania major | C-8 sterol isomerase-like protein | 0.0743 | 0.8336 | 1 |
Mycobacterium leprae | Probable formamidopyrimidine-DNA glycosylase Fpg (FAPY-DNA GLYCOSYLASE) | 0.0112 | 0.1057 | 1 |
Wolbachia endosymbiont of Brugia malayi | formamidopyrimidine-DNA glycosylase | 0.0112 | 0.1057 | 1 |
Mycobacterium tuberculosis | Probable formamidopyrimidine-DNA glycosylase Fpg (FAPY-DNA glycosylase) | 0.0112 | 0.1057 | 1 |
Giardia lamblia | Isoleucyl-tRNA synthetase | 0.0032 | 0.013 | 0.5 |
Trichomonas vaginalis | isoleucyl tRNA synthetase, putative | 0.0032 | 0.013 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | = 3.9 ng ml-1 | Inhibitory activity against isoleucyl-tRNA synthetase (IRS) of S. aureus | ChEMBL. | 8784459 |
IC50 (functional) | = 3.9 ng ml-1 | Inhibitory activity against isoleucyl-tRNA synthetase (IRS) of S. aureus | ChEMBL. | 8784459 |
MIC (functional) | < 0.06 ug ml-1 | compound was tested for antibacterial activity against E. coli DC2. | ChEMBL. | 8784459 |
MIC (functional) | < 0.06 ug ml-1 | compound was tested for antibacterial activity against Strep. pneumoniae 1761. | ChEMBL. | 8784459 |
MIC (functional) | < 0.06 ug ml-1 | compound was tested for antibacterial activity against E. coli DC2. | ChEMBL. | 8784459 |
MIC (functional) | = 0.125 ug ml-1 | compound was tested for antibacterial activity against S. pyogenes CN10. | ChEMBL. | 8784459 |
MIC (functional) | = 0.125 ug ml-1 | compound was tested for antibacterial activity aagainst S. epidermidis PHLN 20. | ChEMBL. | 8784459 |
MIC (functional) | = 0.125 ug ml-1 | compound was tested for antibacterial activity against S. aureus NCTC 6571. | ChEMBL. | 8784459 |
MIC (functional) | = 0.25 ug ml-1 | compound was tested for antibacterial activity against H. influenzae Q1. | ChEMBL. | 8784459 |
MIC (functional) | = 1 ug ml-1 | compound was tested for antibacterial activity against M. catarrhalis 1502. | ChEMBL. | 8784459 |
MIC (functional) | = 32 ug ml-1 | compound was tested for antibacterial activity against Ent. cloacae N1. | ChEMBL. | 8784459 |
MIC (functional) | = 32 ug ml-1 | compound was tested for antibacterial activity against Ent. faecalis I | ChEMBL. | 8784459 |
MIC (functional) | > 64 ug ml-1 | compound was tested for antibacterial activity B. fragilis NCTC 10581. | ChEMBL. | 8784459 |
MIC (functional) | = 64 ug ml-1 | compound was tested for antibacterial activity against E. coli DC0. | ChEMBL. | 8784459 |
MIC (functional) | > 64 ug ml-1 | compound was tested for antibacterial activity against P. aeruginosa K799 wt. | ChEMBL. | 8784459 |
MIC (functional) | > 64 ug ml-1 | compound was tested for antibacterial activity against K. pneumoniae E70. | ChEMBL. | 8784459 |
MIC (functional) | > 64 ug ml-1 | compound was tested for antibacterial activity against Pr. mirabilis C889. | ChEMBL. | 8784459 |
MIC (functional) | > 64 ug ml-1 | compound was tested for antibacterial activity against S. aureus C 37. | ChEMBL. | 8784459 |
MIC (functional) | > 64 ug ml-1 | compound was tested for antibacterial activity against S. aureus F 89. | ChEMBL. | 8784459 |
MIC (functional) | = 64 ug ml-1 | compound was tested for antibacterial activity against E. coli DC0. | ChEMBL. | 8784459 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.