Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0128 | 0.167 | 0.167 |
Schistosoma mansoni | metabotropic glutamate receptor | 0.0088 | 0.1007 | 0.3584 |
Brugia malayi | metabotropic glutamate receptor subtype 5a (mGluR5a), putative | 0.0156 | 0.2139 | 0.2139 |
Loa Loa (eye worm) | glutamate receptor | 0.0068 | 0.0676 | 0.0676 |
Brugia malayi | Receptor family ligand binding region containing protein | 0.0048 | 0.0347 | 0.0347 |
Echinococcus multilocularis | metabotropic glutamate receptor 2 | 0.0148 | 0.2007 | 0.5007 |
Brugia malayi | follicle stimulating hormone receptor | 0.0226 | 0.3301 | 0.3301 |
Schistosoma mansoni | metabotropic glutamate receptor | 0.0148 | 0.2007 | 0.7164 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0027 | 0 | 0.5 |
Onchocerca volvulus | Poor gastrulation protein homolog | 0.0028 | 0.0016 | 0.5 |
Brugia malayi | MH2 domain containing protein | 0.0128 | 0.167 | 0.167 |
Loa Loa (eye worm) | follicle stimulating hormone receptor | 0.0226 | 0.3301 | 0.3301 |
Brugia malayi | metabotropic glutamate receptor type 2 | 0.0088 | 0.1007 | 0.1007 |
Brugia malayi | Metabotropic glutamate receptor precursor. | 0.0176 | 0.247 | 0.247 |
Echinococcus granulosus | GPCR family 3 C terminal | 0.0028 | 0.0016 | 0.0033 |
Toxoplasma gondii | LsmAD domain-containing protein | 0.0027 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0251 | 0.3705 | 0.3705 |
Loa Loa (eye worm) | glutamate receptor | 0.0176 | 0.247 | 0.247 |
Onchocerca volvulus | Metabotropic glutamate receptor homolog | 0.0028 | 0.0016 | 0.5 |
Plasmodium vivax | ataxin-2 like protein, putative | 0.0027 | 0 | 0.5 |
Schistosoma mansoni | metabotropic glutamate receptor 2 3 (mglur group 2) | 0.0196 | 0.2799 | 1 |
Echinococcus granulosus | metabotropic glutamate receptor 2 | 0.0148 | 0.2007 | 0.6405 |
Loa Loa (eye worm) | metabotropic GABA-B receptor subtype 2 | 0.0048 | 0.0347 | 0.0347 |
Loa Loa (eye worm) | hypothetical protein | 0.0048 | 0.0347 | 0.0347 |
Schistosoma mansoni | hypothetical protein | 0.0028 | 0.0016 | 0.0037 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0027 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0275 | 0.411 | 0.411 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0027 | 0 | 0.5 |
Echinococcus multilocularis | metabotropic glutamate receptor 5 | 0.0216 | 0.313 | 0.7818 |
Loa Loa (eye worm) | hypothetical protein | 0.0183 | 0.2577 | 0.2577 |
Loa Loa (eye worm) | hypothetical protein | 0.0216 | 0.313 | 0.313 |
Loa Loa (eye worm) | hypothetical protein | 0.0028 | 0.0016 | 0.0016 |
Loa Loa (eye worm) | angiotensin-converting enzyme family protein | 0.0631 | 1 | 1 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0128 | 0.167 | 0.167 |
Echinococcus granulosus | metabotropic glutamate receptor 5 | 0.0216 | 0.313 | 1 |
Echinococcus multilocularis | GPCR, family 3, C terminal | 0.0028 | 0.0016 | 0.0026 |
Leishmania major | hypothetical protein, conserved | 0.0027 | 0 | 0.5 |
Schistosoma mansoni | NAALADASE L peptidase (M28 family) | 0.0176 | 0.2468 | 0.8816 |
Loa Loa (eye worm) | receptor family ligand binding region containing protein | 0.0048 | 0.0347 | 0.0347 |
Brugia malayi | metabotropic GABA-B receptor subtype 2 | 0.0028 | 0.0016 | 0.0016 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0027 | 0 | 0.5 |
Echinococcus multilocularis | n acetylated alpha linked acidic dipeptidase 2 | 0.0269 | 0.4002 | 1 |
Trypanosoma brucei | PAB1-binding protein , putative | 0.0027 | 0 | 0.5 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.