Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Rattus norvegicus | Thromboxane-A synthase | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Dictyostelium discoideum | cytochrome P450 family protein | Thromboxane-A synthase | 533 aa | 456 aa | 22.4 % |
Trypanosoma brucei gambiense | cytochrome P450, putative | Thromboxane-A synthase | 533 aa | 450 aa | 20.9 % |
Trypanosoma cruzi | cytochrome P450, putative | Thromboxane-A synthase | 533 aa | 448 aa | 20.5 % |
Candida albicans | cytochrome P450 56 | Thromboxane-A synthase | 533 aa | 507 aa | 22.9 % |
Dictyostelium discoideum | cytochrome P450 family protein | Thromboxane-A synthase | 533 aa | 544 aa | 19.9 % |
Leishmania infantum | cytochrome p450-like protein | Thromboxane-A synthase | 533 aa | 473 aa | 22.2 % |
Dictyostelium discoideum | cytochrome P450 family protein | Thromboxane-A synthase | 533 aa | 530 aa | 22.6 % |
Leishmania major | cytochrome p450-like protein | Thromboxane-A synthase | 533 aa | 468 aa | 22.0 % |
Loa Loa (eye worm) | cytochrome P450 family protein | Thromboxane-A synthase | 533 aa | 480 aa | 20.8 % |
Trypanosoma cruzi | cytochrome P450, putative | Thromboxane-A synthase | 533 aa | 450 aa | 20.7 % |
Trypanosoma brucei | cytochrome P450, putative | Thromboxane-A synthase | 533 aa | 450 aa | 20.9 % |
Leishmania donovani | cytochrome p450-like protein | Thromboxane-A synthase | 533 aa | 473 aa | 22.2 % |
Trypanosoma congolense | cytochrome P450, putative | Thromboxane-A synthase | 533 aa | 453 aa | 20.3 % |
Onchocerca volvulus | Thromboxane-A synthase | 533 aa | 507 aa | 21.7 % | |
Leishmania mexicana | cytochrome p450-like protein | Thromboxane-A synthase | 533 aa | 469 aa | 22.0 % |
Leishmania braziliensis | cytochrome p450-like protein | Thromboxane-A synthase | 533 aa | 477 aa | 20.3 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Onchocerca volvulus | Vesicular acetylcholine transporter homolog | 0.0933 | 1 | 0.5 |
Trypanosoma cruzi | C-8 sterol isomerase, putative | 0.0384 | 0.2548 | 0.5 |
Schistosoma mansoni | vesicular acetylcholine transporter | 0.0933 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0384 | 0.2548 | 0.2548 |
Trypanosoma brucei | C-8 sterol isomerase, putative | 0.0384 | 0.2548 | 0.5 |
Loa Loa (eye worm) | vesicular acetylcholine transporter unc-17 | 0.0933 | 1 | 1 |
Echinococcus granulosus | vesicular acetylcholine transporter | 0.0933 | 1 | 0.5 |
Echinococcus multilocularis | vesicular acetylcholine transporter | 0.0933 | 1 | 0.5 |
Leishmania major | C-8 sterol isomerase-like protein | 0.0384 | 0.2548 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | > 1 uM | In vitro inhibition of thromboxane-A2 synthase in rat whole blood during clotting at 37 degrees centigrade | ChEMBL. | 7932586 |
IC50 (binding) | > 1 uM | In vitro inhibition of thromboxane-A2 synthase in rat whole blood during clotting at 37 degrees centigrade | ChEMBL. | 7932586 |
IC50 (binding) | = 74.5 uM | In vitro thromboxane-A2 receptor binding affinity to displace by 50% [3H]-SQ 29548 binding from washed human platelets | ChEMBL. | 7932586 |
IC50 (binding) | = 74.5 uM | In vitro thromboxane-A2 receptor binding affinity to displace by 50% [3H]-SQ 29548 binding from washed human platelets | ChEMBL. | 7932586 |
Inhibition (binding) | = 2 % | Tested for in vitro inhibition of TxA synthase in rat whole blood at 1 uM | ChEMBL. | 7932586 |
Inhibition (binding) | = 2 % | Tested for in vitro inhibition of TxA synthase in rat whole blood at 1 uM | ChEMBL. | 7932586 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.