Species | Target name | Source | Bibliographic reference |
---|---|---|---|
West Nile virus | Genome polyprotein | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | endoplasmic reticulum metallopeptidase 1 | 0.0091 | 0 | 0.5 |
Trypanosoma brucei | glutaminyl cyclase, putative | 0.0091 | 0 | 0.5 |
Brugia malayi | Peptidase family M28 containing protein | 0.0091 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.1281 | 0.905 | 0.905 |
Echinococcus multilocularis | n acetylated alpha linked acidic dipeptidase 2 | 0.1373 | 0.9745 | 1 |
Toxoplasma gondii | peptidase, M28 family protein | 0.0091 | 0 | 0.5 |
Leishmania major | hypothetical protein, conserved | 0.0091 | 0 | 0.5 |
Onchocerca volvulus | Glutaminyl cyclase homolog | 0.0091 | 0 | 0.5 |
Brugia malayi | nicalin | 0.0091 | 0 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0091 | 0 | 0.5 |
Trypanosoma cruzi | glutaminyl cyclase, putative | 0.0091 | 0 | 0.5 |
Mycobacterium ulcerans | lipoprotein aminopeptidase LpqL | 0.0125 | 0.0255 | 1 |
Onchocerca volvulus | Fxna peptidase homolog | 0.0091 | 0 | 0.5 |
Echinococcus granulosus | endoplasmic reticulum metallopeptidase 1 | 0.0091 | 0 | 0.5 |
Schistosoma mansoni | NAALADASE L peptidase (M28 family) | 0.0899 | 0.6146 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0933 | 0.6401 | 0.6401 |
Onchocerca volvulus | Fxna peptidase homolog | 0.0091 | 0 | 0.5 |
Trypanosoma cruzi | glutaminyl cyclase, putative | 0.0091 | 0 | 0.5 |
Brugia malayi | FXNA | 0.0091 | 0 | 0.5 |
Onchocerca volvulus | 0.0091 | 0 | 0.5 | |
Trichomonas vaginalis | conserved hypothetical protein | 0.0091 | 0 | 0.5 |
Onchocerca volvulus | Fxna peptidase homolog | 0.0091 | 0 | 0.5 |
Leishmania major | glutaminyl cyclase, putative | 0.0091 | 0 | 0.5 |
Brugia malayi | leucyl aminopeptidase | 0.0091 | 0 | 0.5 |
Toxoplasma gondii | hypothetical protein | 0.0091 | 0 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0091 | 0 | 0.5 |
Mycobacterium tuberculosis | Probable lipoprotein aminopeptidase LpqL | 0.0125 | 0.0255 | 1 |
Echinococcus granulosus | glutaminyl peptide cyclotransferase | 0.0091 | 0 | 0.5 |
Trichomonas vaginalis | Clan MH, family M28, aminopeptidase S-like metallopeptidase | 0.0091 | 0 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 1.01 uM | Inhibition of WNV NS2B-NS3 protease expressed in Escherichia coli BL21 lambda (DE3) cells using Abz-Gly-Leu-Lys-Arg-Gly-Gly-3-(NO2)Tyr as substrate preincubated for 15 mins followed by substrate addition measured for 15 mins by FRET assay | ChEMBL. | 26233795 |
Inhibition (binding) | = 10.1 % | Inhibition of thrombin (unknown origin) using Boc-Val-Pro-Arg-AMC as substrate at 25 uM preincubated for 15 mins followed by substrate addition measured for 10 mins by FRET assay relative to control | ChEMBL. | 26233795 |
Inhibition (binding) | = 98.8 % | Inhibition of WNV NS2B-NS3 protease expressed in Escherichia coli BL21 lambda (DE3) cells using Abz-Gly-Leu-Lys-Arg-Gly-Gly-3-(NO2)Tyr as substrate at 50 uM preincubated for 15 mins followed by substrate addition measured for 15 mins by FRET assay relative to control | ChEMBL. | 26233795 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.