Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | steroid sulfatase (microsomal), isozyme S | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Brugia malayi | hypothetical protein | Get druggable targets OG5_130476 | All targets in OG5_130476 |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Mycobacterium ulcerans | arylsulfatase AtsB | steroid sulfatase (microsomal), isozyme S | 583 aa | 470 aa | 23.6 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | Calcium binding EGF domain containing protein | 0.0479 | 0.2325 | 1 |
Toxoplasma gondii | calcium binding egf domain-containing protein | 0.0479 | 0.2325 | 0.5 |
Echinococcus multilocularis | fibrillin 1 | 0.0479 | 0.2325 | 0.0706 |
Brugia malayi | zinc metalloproteinase toh-2 precursor | 0.0186 | 0.0093 | 0.0398 |
Loa Loa (eye worm) | hypothetical protein | 0.043 | 0.1957 | 0.1957 |
Loa Loa (eye worm) | hypothetical protein | 0.1424 | 0.9539 | 0.9539 |
Loa Loa (eye worm) | hypothetical protein | 0.0604 | 0.3285 | 0.3285 |
Schistosoma mansoni | subfamily M12A unassigned peptidase (M12 family) | 0.1484 | 1 | 1 |
Loa Loa (eye worm) | multiple epidermal growth factor-like domains 6 | 0.0479 | 0.2325 | 0.2325 |
Loa Loa (eye worm) | bone morphogenetic protein 1b | 0.1484 | 1 | 1 |
Brugia malayi | astacin protease protein 30 | 0.0186 | 0.0093 | 0.0398 |
Loa Loa (eye worm) | hypothetical protein | 0.0186 | 0.0093 | 0.0093 |
Brugia malayi | hypothetical protein | 0.0347 | 0.1322 | 0.5686 |
Loa Loa (eye worm) | matrixin family protein | 0.0268 | 0.0713 | 0.0713 |
Onchocerca volvulus | 0.0186 | 0.0093 | 0.0473 | |
Onchocerca volvulus | Matrix metalloproteinase homolog | 0.0245 | 0.0545 | 0.2783 |
Echinococcus multilocularis | Tolloid protein 1 | 0.1484 | 1 | 1 |
Loa Loa (eye worm) | AStacin protease | 0.0928 | 0.5754 | 0.5754 |
Brugia malayi | Low-density lipoprotein receptor repeat class B containing protein | 0.043 | 0.1957 | 0.8416 |
Toxoplasma gondii | calcium binding egf domain-containing protein | 0.0479 | 0.2325 | 0.5 |
Brugia malayi | Matrixin family protein | 0.0268 | 0.0713 | 0.3069 |
Echinococcus granulosus | laminin | 0.0479 | 0.2325 | 0.0706 |
Brugia malayi | Zinc metalloproteinase toh-2 precursor | 0.0186 | 0.0093 | 0.0398 |
Onchocerca volvulus | Arrow homolog | 0.043 | 0.1957 | 1 |
Loa Loa (eye worm) | low-density lipoprotein receptor repeat class B containing protein | 0.043 | 0.1957 | 0.1957 |
Brugia malayi | Nematode astacin protease protein 30 | 0.0186 | 0.0093 | 0.0398 |
Brugia malayi | Fibulin-1 precursor | 0.0479 | 0.2325 | 1 |
Loa Loa (eye worm) | zinc metalloproteinase toh-2 | 0.0186 | 0.0093 | 0.0093 |
Loa Loa (eye worm) | DPY-31 protein | 0.0186 | 0.0093 | 0.0093 |
Loa Loa (eye worm) | hypothetical protein | 0.0479 | 0.2325 | 0.2325 |
Loa Loa (eye worm) | matrixin family protein | 0.0245 | 0.0545 | 0.0545 |
Loa Loa (eye worm) | hypothetical protein | 0.043 | 0.1957 | 0.1957 |
Brugia malayi | Nematode astacin protease protein 30 | 0.0186 | 0.0093 | 0.0398 |
Onchocerca volvulus | Matrilysin homolog | 0.0245 | 0.0545 | 0.2783 |
Echinococcus multilocularis | laminin | 0.0479 | 0.2325 | 0.0706 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 4.32 uM | Inhibitory activity against Steroid sulfatase expressed in CHO cells | ChEMBL. | 14552755 |
IC50 (binding) | = 4.32 uM | Inhibitory activity against Steroid sulfatase expressed in CHO cells | ChEMBL. | 14552755 |
IC50 (binding) | = 6.2 uM | Inhibitory activity against purified human Steroid sulfatase | ChEMBL. | 14552755 |
IC50 (binding) | = 6.2 uM | Inhibitory activity against purified human Steroid sulfatase | ChEMBL. | 14552755 |
Ki (binding) | uM | Inhibitory constant against purified human Steroid sulfatase; ND= not done | ChEMBL. | 14552755 |
Ki (binding) | ND 0 uM | Inhibitory constant against purified human Steroid sulfatase; ND= not done | ChEMBL. | 14552755 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.