Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | coagulation factor II (thrombin) | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | DPY-31 protein | 0.0102 | 0.0144 | 0.0093 |
Brugia malayi | Calcium binding EGF domain containing protein | 0.0263 | 0.2365 | 1 |
Loa Loa (eye worm) | zinc metalloproteinase toh-2 | 0.0102 | 0.0144 | 0.0093 |
Brugia malayi | Nematode astacin protease protein 30 | 0.0102 | 0.0144 | 0.0608 |
Schistosoma mansoni | egf-like domain protein | 0.0236 | 0.1998 | 0.1998 |
Echinococcus granulosus | laminin | 0.0263 | 0.2365 | 0.0471 |
Loa Loa (eye worm) | matrixin family protein | 0.0144 | 0.0717 | 0.0668 |
Onchocerca volvulus | Matrilysin homolog | 0.0144 | 0.0717 | 0.3587 |
Echinococcus multilocularis | fibrillin 1 | 0.0263 | 0.2365 | 0.0471 |
Toxoplasma gondii | calcium binding egf domain-containing protein | 0.0263 | 0.2365 | 0.5 |
Brugia malayi | Zinc metalloproteinase toh-2 precursor | 0.0102 | 0.0144 | 0.0608 |
Onchocerca volvulus | Arrow homolog | 0.0236 | 0.1998 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0236 | 0.1998 | 0.1957 |
Brugia malayi | Nematode astacin protease protein 30 | 0.0102 | 0.0144 | 0.0608 |
Loa Loa (eye worm) | bone morphogenetic protein 1b | 0.0815 | 1 | 1 |
Brugia malayi | astacin protease protein 30 | 0.0102 | 0.0144 | 0.0608 |
Onchocerca volvulus | Matrix metalloproteinase homolog | 0.0144 | 0.0717 | 0.3587 |
Loa Loa (eye worm) | hypothetical protein | 0.0102 | 0.0144 | 0.0093 |
Echinococcus multilocularis | Tolloid protein 1 | 0.0815 | 1 | 1 |
Loa Loa (eye worm) | low-density lipoprotein receptor repeat class B containing protein | 0.0236 | 0.1998 | 0.1957 |
Loa Loa (eye worm) | matrixin family protein | 0.0157 | 0.0896 | 0.0848 |
Onchocerca volvulus | 0.0102 | 0.0144 | 0.072 | |
Brugia malayi | Calcium binding EGF domain containing protein | 0.0096 | 0.0052 | 0.0219 |
Loa Loa (eye worm) | AStacin protease | 0.051 | 0.5776 | 0.5754 |
Brugia malayi | Matrixin family protein | 0.0157 | 0.0896 | 0.3788 |
Loa Loa (eye worm) | hypothetical protein | 0.0263 | 0.2365 | 0.2325 |
Onchocerca volvulus | Putative cubilin | 0.0096 | 0.0052 | 0.0259 |
Loa Loa (eye worm) | hypothetical protein | 0.0236 | 0.1998 | 0.1957 |
Toxoplasma gondii | calcium binding egf domain-containing protein | 0.0263 | 0.2365 | 0.5 |
Brugia malayi | Fibulin-1 precursor | 0.0263 | 0.2365 | 1 |
Echinococcus multilocularis | laminin | 0.0263 | 0.2365 | 0.0471 |
Brugia malayi | Low-density lipoprotein receptor repeat class B containing protein | 0.0236 | 0.1998 | 0.8451 |
Brugia malayi | zinc metalloproteinase toh-2 precursor | 0.0102 | 0.0144 | 0.0608 |
Schistosoma mansoni | subfamily M12A unassigned peptidase (M12 family) | 0.0815 | 1 | 1 |
Loa Loa (eye worm) | multiple epidermal growth factor-like domains 6 | 0.0263 | 0.2365 | 0.2325 |
Loa Loa (eye worm) | hypothetical protein | 0.0332 | 0.332 | 0.3285 |
Loa Loa (eye worm) | hypothetical protein | 0.0782 | 0.9542 | 0.9539 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.