Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | bromodomain containing 4 | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma brucei | AAA ATPase, putative | 0.0076 | 0.6602 | 0.5 |
Trichomonas vaginalis | bromodomain-containing protein, putative | 0.0059 | 0.3163 | 0.3163 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0048 | 0.0766 | 0.0766 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0059 | 0.3163 | 0.3163 |
Echinococcus multilocularis | ATPase family AAA domain containing protein 2B | 0.0076 | 0.6602 | 0.6602 |
Trypanosoma cruzi | ATPase, putative | 0.0064 | 0.4205 | 0.5 |
Giardia lamblia | Kinase, putative | 0.0044 | 0 | 0.5 |
Trichomonas vaginalis | bromodomain-containing protein, putative | 0.0092 | 1 | 1 |
Echinococcus granulosus | bromodomain containing 2 | 0.0092 | 1 | 1 |
Leishmania major | ATPase, putative | 0.0064 | 0.4205 | 0.5 |
Trichomonas vaginalis | bromodomain-containing protein, putative | 0.0092 | 1 | 1 |
Toxoplasma gondii | bromodomain-containing protein | 0.0044 | 0 | 0.5 |
Echinococcus multilocularis | bromodomain containing 2 | 0.0092 | 1 | 1 |
Entamoeba histolytica | bromodomain-containing protein | 0.0044 | 0 | 0.5 |
Schistosoma mansoni | bromodomain-containing protein 3 brd3 | 0.0092 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0076 | 0.6602 | 0.6602 |
Trichomonas vaginalis | bromodomain containing protein, putative | 0.0059 | 0.3163 | 0.3163 |
Brugia malayi | Bromodomain containing protein | 0.0092 | 1 | 1 |
Entamoeba histolytica | bromodomain-containing protein | 0.0044 | 0 | 0.5 |
Trichomonas vaginalis | bromodomain-containing protein, putative | 0.0059 | 0.3163 | 0.3163 |
Onchocerca volvulus | 0.0044 | 0 | 0.5 | |
Trichomonas vaginalis | bromodomain-containing protein, putative | 0.0059 | 0.3163 | 0.3163 |
Loa Loa (eye worm) | hypothetical protein | 0.0092 | 1 | 1 |
Entamoeba histolytica | bromodomain-containing protein | 0.0044 | 0 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 4.2 | Displacement of histone H4 peptide from FLAG-6His-Tev-ATAD2 (981 to 1121) (unknown origin) expressed in Escherichia coli BL21 (DE3) after 30 mins by TR-FRET analysis relative to control | ChEMBL. | 26230603 |
IC50 (binding) | = 4.9 | Displacement of I-BET762 from 6His-Thr-BRD4 (1 to 477) BD1 (unknown origin) harboring BD2 Y390A mutant after 30 mins by TR-FRET analysis | ChEMBL. | 26230603 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.