Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Rattus norvegicus | Dihydrofolate reductase | Starlite/ChEMBL | References |
Pneumocystis carinii | Dihydrofolate reductase | Starlite/ChEMBL | References |
Toxoplasma gondii | bifunctional dihydrofolate reductase-thymidylate synthase | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | cAMP dependent protein kinase catalytic subunit | 0.0158 | 0.2247 | 0.1802 |
Trypanosoma brucei | protein kinase A catalytic subunit, putative | 0.0158 | 0.2247 | 0.2709 |
Loa Loa (eye worm) | hypothetical protein | 0.0158 | 0.2247 | 0.1802 |
Echinococcus granulosus | thymidylate synthase | 0.013 | 0.1538 | 0.1051 |
Echinococcus multilocularis | thymidylate synthase | 0.013 | 0.1538 | 0.1051 |
Echinococcus multilocularis | dihydrofolate reductase | 0.0468 | 1 | 1 |
Schistosoma mansoni | dihydrofolate reductase | 0.0468 | 1 | 1 |
Brugia malayi | thymidylate synthase | 0.013 | 0.1538 | 0.1051 |
Toxoplasma gondii | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0341 | 0.6832 | 1 |
Echinococcus multilocularis | cAMP dependent protein kinase catalytic subunit | 0.0158 | 0.2247 | 0.1802 |
Onchocerca volvulus | 0.013 | 0.1538 | 1 | |
Loa Loa (eye worm) | AGC/PKA protein kinase | 0.0158 | 0.2247 | 0.1802 |
Trypanosoma brucei | dihydrofolate reductase-thymidylate synthase | 0.0341 | 0.6832 | 1 |
Echinococcus granulosus | enhancer of mRNA decapping protein 4 | 0.0155 | 0.2181 | 0.1732 |
Trypanosoma cruzi | cAMP-dependent protein kinase catalytic subunit 3 | 0.0158 | 0.2247 | 0.2709 |
Mycobacterium tuberculosis | Dihydrofolate reductase DfrA (DHFR) (tetrahydrofolate dehydrogenase) | 0.0468 | 1 | 1 |
Echinococcus multilocularis | cAMP dependent protein kinase catalytic subunit | 0.0158 | 0.2247 | 0.1802 |
Trypanosoma cruzi | cAMP-dependent protein kinase catalytic subunit 2 | 0.0158 | 0.2247 | 0.2709 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase | 0.0341 | 0.6832 | 1 |
Trichomonas vaginalis | AGC family protein kinase | 0.0158 | 0.2247 | 1 |
Leishmania major | protein kinase A catalytic subunit isoform 2 | 0.0158 | 0.2247 | 0.2709 |
Trypanosoma cruzi | cAMP-dependent protein kinase catalytic subunit 3 | 0.0158 | 0.2247 | 0.2709 |
Loa Loa (eye worm) | thymidylate synthase | 0.013 | 0.1538 | 0.1051 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0158 | 0.2247 | 0.1802 |
Trypanosoma brucei | cAMP-dependent protein kinase catalytic subunit 1 | 0.0158 | 0.2247 | 0.2709 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0158 | 0.2247 | 0.1802 |
Mycobacterium leprae | DIHYDROFOLATE REDUCTASE DFRA (DHFR) (TETRAHYDROFOLATE DEHYDROGENASE) | 0.0468 | 1 | 1 |
Plasmodium falciparum | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0341 | 0.6832 | 1 |
Chlamydia trachomatis | dihydrofolate reductase | 0.0468 | 1 | 0.5 |
Plasmodium vivax | bifunctional dihydrofolate reductase-thymidylate synthase, putative | 0.0341 | 0.6832 | 1 |
Echinococcus granulosus | cAMP dependent protein kinase catalytic subunit | 0.0158 | 0.2247 | 0.1802 |
Giardia lamblia | Kinase, AGC PKA | 0.0158 | 0.2247 | 1 |
Loa Loa (eye worm) | AGC/PKA protein kinase | 0.0158 | 0.2247 | 0.1802 |
Entamoeba histolytica | PH domain containing protein kinase, putative | 0.0158 | 0.2247 | 1 |
Brugia malayi | Dihydrofolate reductase | 0.0468 | 1 | 1 |
Leishmania major | protein kinase A catalytic subunit | 0.0158 | 0.2247 | 0.2709 |
Toxoplasma gondii | protein kinase, cAMP-dependent, catalytic chain | 0.0158 | 0.2247 | 0.3289 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0158 | 0.2247 | 0.1802 |
Loa Loa (eye worm) | dihydrofolate reductase | 0.0468 | 1 | 1 |
Plasmodium falciparum | cAMP-dependent protein kinase catalytic subunit | 0.0158 | 0.2247 | 0.2709 |
Echinococcus multilocularis | enhancer of mRNA decapping protein 4 | 0.0155 | 0.2181 | 0.1732 |
Brugia malayi | Cyclin, N-terminal domain containing protein | 0.0237 | 0.4227 | 0.3895 |
Toxoplasma gondii | AGC kinase | 0.0158 | 0.2247 | 0.3289 |
Trypanosoma cruzi | cAMP-dependent protein kinase catalytic subunit 1 | 0.0158 | 0.2247 | 0.2709 |
Echinococcus granulosus | cAMP dependent protein kinase catalytic subunit | 0.0158 | 0.2247 | 0.1802 |
Toxoplasma gondii | AGC kinase | 0.0158 | 0.2247 | 0.3289 |
Schistosoma mansoni | bifunctional dihydrofolate reductase-thymidylate synthase | 0.013 | 0.1538 | 0.1051 |
Echinococcus multilocularis | cAMP dependent protein kinase catalytic subunit | 0.0158 | 0.2247 | 0.1802 |
Loa Loa (eye worm) | cyclin domain-containing protein | 0.0237 | 0.4227 | 0.3895 |
Brugia malayi | cAMP-dependent protein kinase catalytic subunit, putative | 0.0158 | 0.2247 | 0.1802 |
Entamoeba histolytica | PH domain containing protein kinase, putative | 0.0158 | 0.2247 | 1 |
Mycobacterium ulcerans | dihydrofolate reductase DfrA | 0.0468 | 1 | 1 |
Leishmania major | protein kinase A catalytic subunit isoform 1 | 0.0158 | 0.2247 | 0.2709 |
Leishmania major | dihydrofolate reductase-thymidylate synthase | 0.0341 | 0.6832 | 1 |
Echinococcus multilocularis | cAMP dependent protein kinase catalytic subunit | 0.0158 | 0.2247 | 0.1802 |
Trypanosoma brucei | cAMP-dependent protein kinase catalytic subunit 2 | 0.0158 | 0.2247 | 0.2709 |
Echinococcus granulosus | dihydrofolate reductase | 0.0468 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 6.3872 | Inhibition of Pneumocystis carinii dihydrofolate reductase | ChEMBL. | 15743188 |
IC50 (binding) | = 6.6198 | Inhibition of rat liver dihydrofolate reductase | ChEMBL. | 15743188 |
IC50 (binding) | = 7.0132 | Inhibition of Toxoplasma gondii dihydrofolate reductase | ChEMBL. | 15743188 |
IC50 (binding) | = 97 nM | Inhibitory activity against purified DHFR (Dihydrofolate reductase) from Toxoplasma gondii. | ChEMBL. | 7658454 |
IC50 (binding) | = 97 nM | Inhibitory activity against purified DHFR (Dihydrofolate reductase) from Toxoplasma gondii. | ChEMBL. | 7658454 |
IC50 (binding) | = 240 nM | Inhibitory activity against purified DHFR (Dihydrofolate reductase) from rat | ChEMBL. | 7658454 |
IC50 (binding) | = 240 nM | Inhibitory activity against purified DHFR (Dihydrofolate reductase) from rat | ChEMBL. | 7658454 |
IC50 (binding) | = 410 nM | Inhibitory activity against purified DHFR (Dihydrofolate reductase) from Pneumocystis carinii. | ChEMBL. | 7658454 |
IC50 (binding) | = 410 nM | Inhibitory activity against purified DHFR (Dihydrofolate reductase) from Pneumocystis carinii. | ChEMBL. | 7658454 |
IC50 (binding) | = 0.097 uM | Inhibition of Toxoplasma gondii dihydrofolate reductase | ChEMBL. | 15743188 |
IC50 (binding) | = 0.097 uM | Inhibition of Toxoplasma gondii dihydrofolate reductase | ChEMBL. | 15743188 |
IC50 (binding) | = 0.24 uM | Inhibition of rat liver dihydrofolate reductase | ChEMBL. | 15743188 |
IC50 (binding) | = 0.24 uM | Inhibition of rat liver dihydrofolate reductase | ChEMBL. | 15743188 |
IC50 (binding) | = 0.41 uM | Inhibition of Pneumocystis carinii dihydrofolate reductase | ChEMBL. | 15743188 |
IC50 (binding) | = 0.41 uM | Inhibition of Pneumocystis carinii dihydrofolate reductase | ChEMBL. | 15743188 |
Log IC50 (binding) | = 6.3872 | Inhibition of Pneumocystis carinii dihydrofolate reductase | ChEMBL. | 15743188 |
Log IC50 (binding) | = 6.6198 | Inhibition of rat liver dihydrofolate reductase | ChEMBL. | 15743188 |
Log IC50 (binding) | = 7.0132 | Inhibition of Toxoplasma gondii dihydrofolate reductase | ChEMBL. | 15743188 |
Selectivity (binding) | = 0.59 | Ratio of IC50 evaluated towards DHFR of rat liver to P. cainii | ChEMBL. | 7658454 |
Selectivity (binding) | = 2.5 | Ratio of IC50 evaluated towards DHFR of rat liver to T. gondii | ChEMBL. | 7658454 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
2 literature references were collected for this gene.