TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 251.715 | Formula: C11H14ClN5
H donors: 0 H acceptors: 2 LogP: 1.92 Rotable bonds: 1
Rule of 5 violations (Lipinski): 1
SMILES: CN1CCN(CC1)c1nc(Cl)cn2c1ncc2
InChi: 1S/C11H14ClN5/c1-15-4-6-16(7-5-15)11-10-13-2-3-17(10)8-9(12)14-11/h2-3,8H,4-7H2,1H3
InChiKey: BAOXQDKNSKBYGR-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.008	0.0256	0.0239
Loa Loa (eye worm)	hypothetical protein	0.008	0.0256	0.0238
Echinococcus granulosus	rhodopsin orphan GPCR	0.008	0.0256	0.0238
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0057	0.0166	0.0148
Entamoeba histolytica	protein kinase, putative	0.0043	0.0111	0.0093
Echinococcus multilocularis	neuropeptide receptor	0.008	0.0256	0.0238
Brugia malayi	Dopamine receptor	0.008	0.0256	0.0238
Loa Loa (eye worm)	G-protein-linked acetylcholine receptor protein 2	0.008	0.0256	0.0238
Schistosoma mansoni	tyrosine kinase	0.0226	0.0842	0.0826
Echinococcus granulosus	tachykinin peptides receptor 99D	0.008	0.0256	0.0238
Echinococcus multilocularis	thyrotropin releasing hormone receptor	0.008	0.0256	0.0238
Loa Loa (eye worm)	hypothetical protein	0.008	0.0256	0.0238
Schistosoma mansoni	tyrosine kinase	0.0027	0.0046	0.0028
Loa Loa (eye worm)	prenyltransferase alpha subunit repeat containing protein	0.2193	0.8737	0.8734
Echinococcus multilocularis	fmrfamide receptor	0.008	0.0256	0.0238
Brugia malayi	protein-tyrosine kinase	0.005	0.0139	0.0121
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0057	0.0166	0.0148
Onchocerca volvulus	Dopamine\/Ecdysteroid receptor homolog	0.008	0.0256	0.1021
Echinococcus multilocularis	serotonin receptor	0.008	0.0256	0.0238
Loa Loa (eye worm)	neuropeptide F receptor	0.008	0.0256	0.0238
Echinococcus multilocularis	tachykinin peptides receptor 99D	0.008	0.0256	0.0238
Brugia malayi	Dopamine receptor protein 1	0.008	0.0256	0.0238
Loa Loa (eye worm)	hypothetical protein	0.008	0.0256	0.0238
Echinococcus multilocularis	tyrosine protein kinase ABL1	0.0233	0.087	0.0853
Loa Loa (eye worm)	hypothetical protein	0.008	0.0256	0.0238
Loa Loa (eye worm)	hypothetical protein	0.008	0.0256	0.0238
Echinococcus granulosus	neuropeptide Y receptor	0.008	0.0256	0.0238
Echinococcus multilocularis	peptide (allatostatin:somatostatin)	0.008	0.0256	0.0238
Brugia malayi	Protein prenyltransferase alpha subunit repeat containing protein	0.2193	0.8737	0.8734
Echinococcus multilocularis	g protein coupled receptor	0.008	0.0256	0.0238
Echinococcus granulosus	growth hormone secretagogue receptor type 1	0.008	0.0256	0.0238
Echinococcus granulosus	somatostatin receptor	0.008	0.0256	0.0238
Loa Loa (eye worm)	hypothetical protein	0.0705	0.2768	0.2754
Brugia malayi	hypothetical protein	0.008	0.0256	0.0238
Schistosoma mansoni	serine/threonine protein kinase	0.0719	0.2821	0.2809
Brugia malayi	Tyrosine-protein kinase abl-1	0.0131	0.0463	0.0445
Schistosoma mansoni	proto-oncogene tyrosine-protein kinase src	0.0027	0.0046	0.0028
Trichomonas vaginalis	geranylgeranyl transferase type II beta subunit, putative	0.049	0.1904	0.0395
Loa Loa (eye worm)	hypothetical protein	0.008	0.0256	0.0238
Schistosoma mansoni	neuropeptide F-like receptor	0.008	0.0256	0.0239
Echinococcus granulosus	tm gpcr rhodopsin	0.008	0.0256	0.0238
Echinococcus multilocularis	dro:myosuppressin receptor	0.008	0.0256	0.0238
Echinococcus granulosus	g protein coupled receptor	0.008	0.0256	0.0238
Plasmodium vivax	prenyltransferase alpha subunit, putative	0.2193	0.8737	1
Schistosoma mansoni	thyrotropin-releasing hormone receptor	0.008	0.0256	0.0239
Loa Loa (eye worm)	hypothetical protein	0.008	0.0256	0.0238
Echinococcus multilocularis	tyrosine protein kinase HCK	0.0043	0.0111	0.0093
Echinococcus multilocularis	G protein coupled receptor 139	0.008	0.0256	0.0238
Schistosoma mansoni	opsin-like receptor	0.008	0.0256	0.0239
Echinococcus multilocularis	tyrosine protein kinase Src64B	0.0057	0.0166	0.0148
Echinococcus multilocularis	protein farnesyltransferase subunit beta	0.049	0.1904	0.1889
Schistosoma mansoni	biogenic amine (5HT) receptor	0.008	0.0256	0.0239
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.008	0.0256	0.0239
Schistosoma mansoni	biogenic amine (octopamine/dopamine) receptor	0.008	0.0256	0.0239
Echinococcus granulosus	rhodopsin orphan GPCR	0.008	0.0256	0.0238
Echinococcus multilocularis	tyrosine protein kinase Blk	0.005	0.0139	0.0121
Schistosoma mansoni	growth hormone secretagogue receptor	0.008	0.0256	0.0239
Echinococcus multilocularis	neuropeptides capa receptor	0.008	0.0256	0.0238
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.008	0.0256	0.0239
Echinococcus granulosus	mitogen activated protein kinase kinase kinase	0.0706	0.2769	0.2756
Loa Loa (eye worm)	hypothetical protein	0.0407	0.1571	0.1555
Brugia malayi	Serotonin receptor	0.008	0.0256	0.0238
Schistosoma mansoni	muscarinic acetylcholine (GAR) receptor	0.008	0.0256	0.0239
Trypanosoma cruzi	protein farnesyltransferase, putative	0.049	0.1904	0.4309
Schistosoma mansoni	amine GPCR	0.008	0.0256	0.0239
Echinococcus granulosus	rhodopsin orphan GPCR	0.008	0.0256	0.0238
Schistosoma mansoni	myosin xvIII	0.008	0.0256	0.0239
Onchocerca volvulus		0.008	0.0256	0.1021
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.008	0.0256	0.0238
Onchocerca volvulus		0.008	0.0256	0.1021
Echinococcus multilocularis	neuropeptide FF receptor 2	0.008	0.0256	0.0238
Plasmodium falciparum	protein farnesyltransferase subunit beta	0.049	0.1904	0.2179
Onchocerca volvulus		0.008	0.0256	0.1021
Loa Loa (eye worm)	follicle stimulating hormone receptor	0.008	0.0256	0.0238
Toxoplasma gondii	hypothetical protein	0.06	0.2344	0.3704
Echinococcus granulosus	neuropeptide FF receptor 2	0.008	0.0256	0.0238
Schistosoma mansoni	peptide (FMRFamide/neurokinin-3)-like receptor	0.008	0.0256	0.0239
Entamoeba histolytica	geranylgeranyl transferase beta subunit	0.2508	1	1
Echinococcus multilocularis	alpha 1A adrenergic receptor	0.008	0.0256	0.0238
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0057	0.0166	0.0148
Brugia malayi	gonadotropin-releasing hormone receptor 2	0.008	0.0256	0.0238
Schistosoma mansoni	protein farnesyltransferase alpha subunit	0.2193	0.8737	0.8734
Trypanosoma brucei	lanosterol synthase	0.0501	0.1948	0.4884
Entamoeba histolytica	protein farnesyltransferase alpha subunit, putative	0.2193	0.8737	0.8734
Trichomonas vaginalis	geranylgeranyl transferase type I beta subunit, putative	0.049	0.1904	0.0395
Plasmodium falciparum	geranylgeranyltransferase, putative	0.0407	0.1571	0.1798
Loa Loa (eye worm)	hypothetical protein	0.008	0.0256	0.0238
Brugia malayi	Serotonin receptor	0.008	0.0256	0.0238
Schistosoma mansoni	neuropeptide F-like receptor	0.008	0.0256	0.0239
Onchocerca volvulus		0.008	0.0256	0.1021
Loa Loa (eye worm)	hypothetical protein	0.008	0.0256	0.0238
Trichomonas vaginalis	protein farnesyltransferase alpha subunit/RAB geranylgeranyl transferase alpha subunit, putative	0.1593	0.6329	0.5645
Brugia malayi	ORL1-like opioid receptor	0.008	0.0256	0.0238
Loa Loa (eye worm)	prenyltransferase alpha subunit repeat containing protein	0.06	0.2344	0.233
Leishmania major	farnesyltransferase beta subunit	0.049	0.1904	0.7831
Echinococcus multilocularis	tyrosine protein kinase Srms	0.005	0.0139	0.0121
Echinococcus multilocularis	c src tyrosine kinase	0.0027	0.0046	0.0027
Loa Loa (eye worm)	gonadotropin-releasing hormone receptor 2	0.008	0.0256	0.0238
Loa Loa (eye worm)	hypothetical protein	0.008	0.0256	0.0238
Schistosoma mansoni	amine GPCR	0.008	0.0256	0.0239
Schistosoma mansoni	neuropeptide receptor	0.008	0.0256	0.0239
Echinococcus granulosus	rhodopsin orphan GPCR	0.008	0.0256	0.0238
Loa Loa (eye worm)	hypothetical protein	0.2193	0.8737	0.8734
Loa Loa (eye worm)	hypothetical protein	0.0705	0.2768	0.2754
Echinococcus granulosus	tyrosine protein kinase HCK	0.0043	0.0111	0.0093
Trichomonas vaginalis	protein farnesyltransferase alpha subunit/RAB geranylgeranyl transferase alpha subunit, putative	0.2193	0.8737	0.8501
Echinococcus multilocularis	g protein coupled receptor	0.008	0.0256	0.0238
Loa Loa (eye worm)	hypothetical protein	0.008	0.0256	0.0238
Onchocerca volvulus		0.008	0.0256	0.1021
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.008	0.0256	0.0239
Loa Loa (eye worm)	prenyltransferase and squalene oxidase repeat family protein	0.049	0.1904	0.1889
Echinococcus granulosus	geranylgeranyl transferase type 2 subunit alpha	0.06	0.2344	0.233
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.008	0.0256	0.0239
Echinococcus granulosus	tyrosine protein kinase Btk29A	0.0027	0.0046	0.0027
Echinococcus granulosus	tyrosine protein kinase Lyn	0.0057	0.0167	0.0149
Echinococcus multilocularis	serotonin receptor	0.008	0.0256	0.0238
Loa Loa (eye worm)	hypothetical protein	0.008	0.0256	0.0238
Schistosoma mansoni	alpha-1 adrenergic receptor	0.008	0.0256	0.0239
Entamoeba histolytica	Rab geranylgeranyltransferase beta subunit, putative	0.0407	0.1571	0.1555
Brugia malayi	Melatonin receptor type 1A	0.008	0.0256	0.0238
Brugia malayi	Tyrosine-protein kinase abl-1	0.0108	0.0371	0.0354
Echinococcus multilocularis	mitogen activated protein kinase kinase kinase	0.0706	0.2769	0.2756
Brugia malayi	Dopamine receptor protein 1, putative (partial)	0.008	0.0256	0.0238
Trypanosoma cruzi	protein farnesyltransferase alpha subunit, putative	0.06	0.2344	1
Echinococcus multilocularis	geranylgeranyl transferase type 2 subunit alpha	0.06	0.2344	0.233
Loa Loa (eye worm)	hypothetical protein	0.008	0.0256	0.0238
Brugia malayi	G protein-coupled receptor	0.008	0.0256	0.0238
Echinococcus multilocularis	tyrosine protein kinase Fgr	0.0057	0.0166	0.0148
Loa Loa (eye worm)	TK protein kinase	0.005	0.0139	0.0121
Schistosoma mansoni	geranylgeranyl transferase type II beta subunit	0.0407	0.1571	0.1556
Schistosoma mansoni	amine GPCR	0.008	0.0256	0.0239
Echinococcus granulosus	g protein coupled receptor	0.008	0.0256	0.0238
Brugia malayi	neuropeptide F receptor	0.008	0.0256	0.0238
Schistosoma mansoni	histamine-responsive GPCR (AAF21638)	0.008	0.0256	0.0239
Loa Loa (eye worm)	TKL/MLK/LZK protein kinase	0.0706	0.2769	0.2756
Echinococcus granulosus	7tm_1 domain containing protein	0.008	0.0256	0.0238
Loa Loa (eye worm)	melatonin receptor type 1A	0.008	0.0256	0.0238
Loa Loa (eye worm)	hypothetical protein	0.008	0.0256	0.0238
Trypanosoma cruzi	hypothetical protein, conserved	0.06	0.2344	1
Loa Loa (eye worm)	hypothetical protein	0.008	0.0256	0.0238
Trichomonas vaginalis	geranylgeranyl transferase type beta subunit, putative	0.049	0.1904	0.0395
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0057	0.0166	0.0148
Toxoplasma gondii	prenyltransferase and squalene oxidase repeat-containing protein	0.049	0.1904	0.3008
Echinococcus multilocularis	biogenic amine (5HT) receptor	0.008	0.0256	0.0238
Trypanosoma cruzi	protein farnesyltransferase alpha subunit, putative	0.06	0.2344	1
Echinococcus granulosus	rhodopsin orphan GPCR	0.008	0.0256	0.0238
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.008	0.0256	0.0238
Schistosoma mansoni	geranylgeranyl transferase type I beta subunit	0.2508	1	1
Schistosoma mansoni	ancient conserved domain protein 2 (cyclin m2)	0.008	0.0256	0.0239
Brugia malayi	Serotonin/octopamine receptor family protein 7	0.008	0.0256	0.0238
Echinococcus multilocularis	allatostatin A receptor	0.008	0.0256	0.0238
Loa Loa (eye worm)	hypothetical protein	0.008	0.0256	0.0238
Loa Loa (eye worm)	hypothetical protein	0.008	0.0256	0.0238
Toxoplasma gondii	prenyltransferase and squalene oxidase repeat-containing protein	0.0407	0.1571	0.2482
Loa Loa (eye worm)	hypothetical protein	0.008	0.0256	0.0238
Echinococcus granulosus	protein farnesyltransferase alpha subunit	0.2193	0.8737	0.8734
Loa Loa (eye worm)	hypothetical protein	0.008	0.0256	0.0238
Loa Loa (eye worm)	G-protein coupled receptor	0.008	0.0256	0.0238
Echinococcus granulosus	alpha 1A adrenergic receptor	0.008	0.0256	0.0238
Loa Loa (eye worm)	hypothetical protein	0.008	0.0256	0.0238
Onchocerca volvulus		0.008	0.0256	0.1021
Schistosoma mansoni	biogenic amine receptor	0.008	0.0256	0.0239
Schistosoma mansoni	neuropeptide receptor	0.008	0.0256	0.0239
Echinococcus multilocularis	protein farnesyltransferase alpha subunit	0.2193	0.8737	0.8734
Trichomonas vaginalis	geranylgeranyl transferase type II beta subunit, putative	0.049	0.1904	0.0395
Schistosoma mansoni	tyrosine kinase	0.0057	0.0166	0.0149
Echinococcus multilocularis	rhodopsin orphan GPCR	0.008	0.0256	0.0238
Brugia malayi	larval opioid receptor	0.008	0.0256	0.0238
Echinococcus granulosus	geranylgeranyl transferase type I beta subunit	0.2508	1	1
Echinococcus granulosus	neuropeptide receptor	0.008	0.0256	0.0238
Brugia malayi	Probable protein farnesyltransferase beta subunit, putative	0.0407	0.1571	0.1555
Echinococcus granulosus	sex peptide receptor	0.008	0.0256	0.0238
Loa Loa (eye worm)	TK/ABL protein kinase	0.0233	0.087	0.0853
Echinococcus granulosus	tyrosine protein kinase Src42A	0.0037	0.0085	0.0067
Trypanosoma brucei	protein farnesyltransferase beta subunit	0.049	0.1904	0.4309
Giardia lamblia	Prenyltransferase	0.049	0.1904	0.0465
Echinococcus granulosus	fmrfamide receptor	0.008	0.0256	0.0238
Echinococcus multilocularis	proto oncogene tyrosine protein kinase LCK	0.0057	0.0166	0.0148
Brugia malayi	putative neuropeptide receptor	0.008	0.0256	0.0238
Loa Loa (eye worm)	hypothetical protein	0.008	0.0256	0.0238
Brugia malayi	hypothetical protein	0.008	0.0256	0.0238
Onchocerca volvulus		0.008	0.0256	0.1021
Echinococcus multilocularis	neuropeptide Y receptor	0.008	0.0256	0.0238
Schistosoma mansoni	amine GPCR	0.008	0.0256	0.0239
Schistosoma mansoni	biogenic amine (5HT) receptor	0.008	0.0256	0.0239
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.008	0.0256	0.0238
Brugia malayi	SRC-1	0.0057	0.0166	0.0148
Trichomonas vaginalis	geranylgeranyl transferase type I beta subunit, putative	0.2508	1	1
Schistosoma mansoni	histamine h1 receptor	0.008	0.0256	0.0239
Plasmodium vivax	protein prenyltransferase alpha subunit, putative	0.06	0.2344	0.2683
Echinococcus multilocularis	rhodopsin orphan GPCR	0.008	0.0256	0.0238
Echinococcus multilocularis	rhodopsin orphan GPCR	0.008	0.0256	0.0238
Onchocerca volvulus		0.008	0.0256	0.1021
Loa Loa (eye worm)	hypothetical protein	0.0407	0.1571	0.1555
Echinococcus granulosus	rhodopsin orphan GPCR	0.008	0.0256	0.0238
Trichomonas vaginalis	protein farnesyltransferase alpha subunit, putative	0.2193	0.8737	0.8501
Onchocerca volvulus		0.06	0.2344	1
Plasmodium falciparum	geranylgeranyl transferase type2 beta subunit, putative	0.0407	0.1571	0.1798
Trypanosoma cruzi	lanosterol synthase, putative	0.0501	0.1948	0.4884
Toxoplasma gondii	hypothetical protein	0.1593	0.6329	1
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.008	0.0256	0.0239
Echinococcus granulosus	tm gpcr rhodopsin	0.008	0.0256	0.0238
Echinococcus granulosus	rhodopsin orphan GPCR	0.008	0.0256	0.0238
Echinococcus granulosus	neuropeptide s receptor	0.008	0.0256	0.0238
Schistosoma mansoni	opsin-like receptor	0.008	0.0256	0.0239
Echinococcus granulosus	thyrotropin releasing hormone receptor	0.008	0.0256	0.0238
Echinococcus granulosus	neuropeptide receptor	0.008	0.0256	0.0238
Giardia lamblia	Rab geranylgeranyltransferase	0.06	0.2344	0.1079
Echinococcus granulosus	7TM GPCR rhodopsin	0.008	0.0256	0.0238
Brugia malayi	neuropeptide F receptor	0.008	0.0256	0.0238
Loa Loa (eye worm)	hypothetical protein	0.008	0.0256	0.0238
Loa Loa (eye worm)	hypothetical protein	0.008	0.0256	0.0238
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.008	0.0256	0.0238
Loa Loa (eye worm)	hypothetical protein	0.008	0.0256	0.0238
Echinococcus granulosus	protein prenyltransferase alpha subunit	0.06	0.2344	0.233
Onchocerca volvulus		0.008	0.0256	0.1021
Trichomonas vaginalis	protein farnesyltransferase alpha subunit, putative	0.06	0.2344	0.0918
Echinococcus granulosus	g protein coupled receptor	0.008	0.0256	0.0238
Echinococcus multilocularis	g protein coupled receptor	0.008	0.0256	0.0238
Plasmodium vivax	geranylgeranyltransferase, putative	0.0407	0.1571	0.1798
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.008	0.0256	0.0239
Echinococcus granulosus	protein farnesyltransferase subunit beta	0.049	0.1904	0.1889
Brugia malayi	Dopamine receptor protein 2	0.008	0.0256	0.0238
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.008	0.0256	0.0239
Echinococcus granulosus	dro:myosuppressin receptor	0.008	0.0256	0.0238
Schistosoma mansoni	neuropeptide receptor	0.008	0.0256	0.0239
Echinococcus multilocularis	tyrosine protein kinase Abl	0.0108	0.0371	0.0354
Echinococcus granulosus	c src tyrosine kinase	0.0027	0.0046	0.0027
Loa Loa (eye worm)	hypothetical protein	0.008	0.0256	0.0238
Echinococcus multilocularis	sex peptide receptor	0.008	0.0256	0.0238
Schistosoma mansoni	peptide (allatostatin/somatostatin)-like receptor	0.008	0.0256	0.0239
Brugia malayi	hypothetical protein	0.008	0.0256	0.0238
Brugia malayi	hypothetical protein	0.008	0.0256	0.0238
Brugia malayi	hypothetical protein	0.008	0.0256	0.0238
Toxoplasma gondii	Rab geranylgeranyl transferase type II beta subunit, putative	0.0407	0.1571	0.2482
Echinococcus multilocularis	neuropeptide receptor	0.008	0.0256	0.0238
Loa Loa (eye worm)	hypothetical protein	0.008	0.0256	0.0238
Echinococcus multilocularis	rhodopsin orphan GPCR	0.008	0.0256	0.0238
Loa Loa (eye worm)	hypothetical protein	0.0095	0.0316	0.0298
Schistosoma mansoni	tyrosine kinase	0.002	0.0018	0.0001
Plasmodium vivax	geranylgeranyl transferase type2 beta subunit, putative	0.0407	0.1571	0.1798
Loa Loa (eye worm)	hypothetical protein	0.008	0.0256	0.0238
Echinococcus granulosus	neuropeptide receptor A26	0.008	0.0256	0.0238
Echinococcus granulosus	tyrosine protein kinase ABL1	0.0233	0.087	0.0853
Loa Loa (eye worm)	hypothetical protein	0.008	0.0256	0.0238
Brugia malayi	hypothetical protein	0.008	0.0256	0.0238
Brugia malayi	RE15519p	0.008	0.0256	0.0238
Echinococcus granulosus	g-protein coupled receptor	0.008	0.0256	0.0238
Echinococcus granulosus	neuropeptide Y receptor	0.008	0.0256	0.0238
Echinococcus granulosus	biogenic amine 5HT receptor	0.008	0.0256	0.0238
Mycobacterium tuberculosis	Halimadienyl diphosphate synthase	0.0501	0.1948	0.5
Echinococcus multilocularis	tyrosine protein kinase Btk29A	0.0027	0.0046	0.0027
Schistosoma mansoni	rab geranylgeranyl transferase alpha subunit	0.06	0.2344	0.233
Loa Loa (eye worm)	hypothetical protein	0.008	0.0256	0.0238
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.008	0.0256	0.0239
Trypanosoma brucei	protein farnesyltransferase alpha subunit, putative	0.06	0.2344	1
Entamoeba histolytica	protein farnesyltransferase beta subunit, putative	0.049	0.1904	0.1889
Trichomonas vaginalis	protein farnesyltransferase alpha subunit, putative	0.2193	0.8737	0.8501
Echinococcus granulosus	allatostatin A receptor	0.008	0.0256	0.0238
Schistosoma mansoni	neuropeptide f receptor 76f	0.008	0.0256	0.0239
Brugia malayi	G protein-coupled receptor F59B2.13	0.008	0.0256	0.0238
Echinococcus multilocularis	protein prenyltransferase alpha subunit	0.06	0.2344	0.233
Echinococcus granulosus	hypothetical protein	0.008	0.0256	0.0238
Echinococcus granulosus	pyroglutamylated rfamide peptide receptor	0.008	0.0256	0.0238
Loa Loa (eye worm)	hypothetical protein	0.008	0.0256	0.0238
Echinococcus multilocularis	neuropeptides capa receptor	0.008	0.0256	0.0238
Trypanosoma cruzi	hypothetical protein, conserved	0.06	0.2344	1
Onchocerca volvulus		0.008	0.0256	0.1021
Brugia malayi	GnHR receptor homolog	0.008	0.0256	0.0238
Schistosoma mansoni	hypothetical protein	0.008	0.0256	0.0239
Loa Loa (eye worm)	TK protein kinase	0.0043	0.0111	0.0093
Loa Loa (eye worm)	hypothetical protein	0.008	0.0256	0.0238
Loa Loa (eye worm)	SRC-1	0.0057	0.0166	0.0148
Echinococcus multilocularis	rhodopsin orphan GPCR	0.008	0.0256	0.0238
Schistosoma mansoni	tyrosine kinase	0.0057	0.0166	0.0149
Loa Loa (eye worm)	hypothetical protein	0.008	0.0256	0.0238
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0057	0.0166	0.0148
Trypanosoma cruzi	lanosterol synthase, putative	0.0501	0.1948	0.4884
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0057	0.0166	0.0148
Schistosoma mansoni	tyrosine kinase	0.002	0.0018	0.0001
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.008	0.0256	0.0239
Echinococcus multilocularis	growth hormone secretagogue receptor type 1	0.008	0.0256	0.0238
Schistosoma mansoni	protein farnesyltransferase subunit beta	0.049	0.1904	0.189
Echinococcus multilocularis	somatostatin receptor	0.008	0.0256	0.0238
Brugia malayi	AKH receptor	0.008	0.0256	0.0238
Brugia malayi	Protein kinase domain containing protein	0.0706	0.2769	0.2756
Loa Loa (eye worm)	hypothetical protein	0.008	0.0256	0.0238
Schistosoma mansoni	adenoreceptor	0.008	0.0256	0.0239
Echinococcus granulosus	tyrosine protein kinase Src42A	0.0057	0.0166	0.0148
Loa Loa (eye worm)	unidentified vitellogenin-linked transcript protein 6	0.008	0.0256	0.0238
Trichomonas vaginalis	geranylgeranyl transferase type II beta subunit, putative	0.049	0.1904	0.0395
Plasmodium falciparum	protein farnesyltransferase subunit alpha	0.2193	0.8737	1
Loa Loa (eye worm)	hypothetical protein	0.008	0.0256	0.0238
Brugia malayi	Unidentified vitellogenin-linked transcript protein 6, putative	0.008	0.0256	0.0238
Schistosoma mansoni	neuropeptide receptor	0.008	0.0256	0.0239
Echinococcus granulosus	tyrosine kinase\|tyrosine protein kinase Fyn	0.005	0.0139	0.0121
Echinococcus granulosus	G protein coupled receptor 139	0.008	0.0256	0.0238
Loa Loa (eye worm)	hypothetical protein	0.008	0.0256	0.0238
Echinococcus multilocularis	G protein coupled 5 hydroxytryptamine receptor	0.008	0.0256	0.0238
Echinococcus granulosus	tyrosine protein kinase Blk	0.005	0.0139	0.0121
Loa Loa (eye worm)	hypothetical protein	0.008	0.0256	0.0238
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.008	0.0256	0.0238
Loa Loa (eye worm)	5-hydroxytryptamine 2C receptor	0.008	0.0256	0.0238
Loa Loa (eye worm)	hypothetical protein	0.008	0.0256	0.0238
Trypanosoma brucei	hypothetical protein, conserved	0.06	0.2344	1
Brugia malayi	hypothetical protein	0.008	0.0256	0.0238
Schistosoma mansoni	opsin-like receptor	0.008	0.0256	0.0239
Echinococcus multilocularis	rhodopsin orphan GPCR	0.008	0.0256	0.0238
Plasmodium vivax	farnesyltransferase beta subunit, putative	0.049	0.1904	0.2179
Echinococcus multilocularis	G-protein coupled receptor, putative	0.008	0.0256	0.0238
Onchocerca volvulus		0.008	0.0256	0.1021
Brugia malayi	G-protein coupled receptor	0.008	0.0256	0.0238
Echinococcus multilocularis	neuropeptide Y receptor	0.008	0.0256	0.0238
Echinococcus multilocularis	neuropeptide receptor A26	0.008	0.0256	0.0238
Brugia malayi	hypothetical protein	0.008	0.0256	0.0238
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.008	0.0256	0.0239
Echinococcus granulosus	G protein coupled 5 hydroxytryptamine receptor	0.008	0.0256	0.0238
Schistosoma mansoni	biogenic amine receptor	0.008	0.0256	0.0239
Schistosoma mansoni	tyrosine kinase	0.0027	0.0046	0.0028
Loa Loa (eye worm)	neuropeptide F receptor	0.008	0.0256	0.0238
Giardia lamblia	Rab geranylgeranyltransferase	0.2193	0.8737	1
Brugia malayi	G-protein coupled receptor	0.008	0.0256	0.0238
Brugia malayi	G-protein-linked acetylcholine receptor protein 2, putative	0.008	0.0256	0.0238
Loa Loa (eye worm)	hypothetical protein	0.008	0.0256	0.0238
Echinococcus granulosus	serotonin receptor	0.008	0.0256	0.0238
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.008	0.0256	0.0238
Echinococcus multilocularis	rhodopsin orphan GPCR	0.008	0.0256	0.0238
Loa Loa (eye worm)	hypothetical protein	0.008	0.0256	0.0238
Loa Loa (eye worm)	hypothetical protein	0.008	0.0256	0.0238
Echinococcus multilocularis	7TM GPCR, rhodopsin	0.008	0.0256	0.0238
Loa Loa (eye worm)	hypothetical protein	0.008	0.0256	0.0238
Leishmania major	geranylgeranyltransferase, putative	0.0407	0.1571	0.6189
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.005	0.0139	0.0121
Brugia malayi	follicle stimulating hormone receptor	0.008	0.0256	0.0238
Echinococcus granulosus	orexin receptor type 2	0.008	0.0256	0.0238
Echinococcus granulosus	tyrosine kinase	0.005	0.0139	0.0121
Brugia malayi	hypothetical protein	0.008	0.0256	0.0238
Echinococcus multilocularis	Rab geranylgeranyltransferase, beta subunit	0.0407	0.1571	0.1555
Echinococcus multilocularis	geranylgeranyl transferase type I beta subunit	0.2508	1	1
Echinococcus granulosus	tm gpcr rhodopsin	0.008	0.0256	0.0238
Trichomonas vaginalis	type I geranylgeranyltransferase beta subunit, putative	0.049	0.1904	0.0395
Schistosoma mansoni	peptide (allatostatin)-like receptor	0.008	0.0256	0.0239
Trypanosoma cruzi	Protein prenyltransferase alpha subunit repeat, putative	0.06	0.2344	1
Brugia malayi	Tachykinin-like peptides receptor 99D	0.008	0.0256	0.0238
Echinococcus multilocularis	rhodopsin orphan GPCR	0.008	0.0256	0.0238
Brugia malayi	putative neuropeptide receptor NPR1	0.008	0.0256	0.0238
Plasmodium falciparum	geranylgeranyl transferase type-2 subunit alpha, putative	0.06	0.2344	0.2683
Echinococcus multilocularis	fmrfamide receptor	0.008	0.0256	0.0238
Schistosoma mansoni	hypothetical protein	0.008	0.0256	0.0239
Plasmodium vivax	conserved Plasmodium protein, unknown function	0.0083	0.027	0.0309
Echinococcus multilocularis	pyroglutamylated rfamide peptide receptor	0.008	0.0256	0.0238
Echinococcus granulosus	neuropeptides capa receptor	0.008	0.0256	0.0238
Echinococcus multilocularis	orexin receptor type 2	0.008	0.0256	0.0238
Trypanosoma cruzi	protein farnesyltransferase, putative	0.049	0.1904	0.4309
Schistosoma mansoni	biogenic amine receptor	0.008	0.0256	0.0239
Echinococcus granulosus	neuropeptides capa receptor	0.008	0.0256	0.0238
Echinococcus multilocularis	tyrosine protein kinase Src42A	0.0057	0.0166	0.0148
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.008	0.0256	0.0239
Echinococcus multilocularis	tyrosine protein kinase lyn tyrosine protein kinase blk	0.0057	0.0166	0.0148
Loa Loa (eye worm)	prenyltransferase and squalene oxidase repeat family protein	0.2508	1	1
Schistosoma mansoni	geranylgeranyl transferase type I beta subunit	0.2508	1	1
Onchocerca volvulus		0.008	0.0256	0.1021
Echinococcus granulosus	3'partial\|tyrosine protein kinase Fgr	0.0057	0.0166	0.0148
Schistosoma mansoni	hypothetical protein	0.008	0.0256	0.0239
Entamoeba histolytica	Rab geranylgeranyltransferase alpha subunit, putative	0.06	0.2344	0.233
Loa Loa (eye worm)	hypothetical protein	0.008	0.0256	0.0238
Echinococcus multilocularis	tyrosine protein kinase Src42A	0.0037	0.0085	0.0067
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.008	0.0256	0.0239
Brugia malayi	Prenyltransferase and squalene oxidase repeat family protein	0.049	0.1904	0.1889
Loa Loa (eye worm)	hypothetical protein	0.008	0.0256	0.0238
Echinococcus multilocularis	neuropeptide s receptor	0.008	0.0256	0.0238
Trypanosoma brucei	Protein prenyltransferase alpha subunit repeat, putative	0.06	0.2344	1
Trypanosoma brucei	Protein prenyltransferase alpha subunit repeat, putative	0.06	0.2344	1
Echinococcus multilocularis	g-protein coupled receptor	0.008	0.0256	0.0238
Onchocerca volvulus		0.008	0.0256	0.1021
Echinococcus granulosus	biogenic amine 5HT receptor	0.008	0.0256	0.0238
Loa Loa (eye worm)	TYRA-2 protein	0.008	0.0256	0.0238
Echinococcus granulosus	tyrosine protein kinase Src64B	0.0057	0.0166	0.0148
Echinococcus granulosus	proto oncogene tyrosine protein kinase LCK	0.0057	0.0166	0.0148
Onchocerca volvulus		0.008	0.0256	0.1021
Loa Loa (eye worm)	hypothetical protein	0.008	0.0256	0.0238
Brugia malayi	hypothetical protein	0.008	0.0256	0.0238
Echinococcus granulosus	peptide allatostatin:somatostatin	0.008	0.0256	0.0238
Onchocerca volvulus	Neuropeptide F receptor homolog	0.008	0.0256	0.1021
Onchocerca volvulus		0.008	0.0256	0.1021
Onchocerca volvulus		0.008	0.0256	0.1021
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.008	0.0256	0.0238
Loa Loa (eye worm)	G-protein coupled receptor	0.008	0.0256	0.0238
Echinococcus multilocularis	tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase	0.0057	0.0166	0.0148
Onchocerca volvulus		0.008	0.0256	0.1021
Schistosoma mansoni	amine GPCR	0.008	0.0256	0.0239
Leishmania major	protein farnesyltransferase alpha subunit, putative	0.06	0.2344	1
Schistosoma mansoni	hypothetical protein	0.008	0.0256	0.0239
Loa Loa (eye worm)	hypothetical protein	0.008	0.0256	0.0238
Brugia malayi	sulfakinin receptor protein	0.008	0.0256	0.0238
Brugia malayi	Protein prenyltransferase alpha subunit repeat containing protein	0.06	0.2344	0.233
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.008	0.0256	0.0239

Activities

Activity type	Activity value	Assay description	Source	Reference
Kd (binding)	= 144 nM	Displacement of [3H]-clonidine from alpha2-adrenergic receptor of calf neocortical membrane	ChEMBL.	6298426
Kd (binding)	= 380 nM	Displacement of [3H]-prazosin from alpha1-adrenergic receptor of calf neocortical membrane	ChEMBL.	6298426
Ratio (binding)	= 2.6	Relative affinity for alpha-1 and alpha-2 adrenergic receptors	ChEMBL.	6298426

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

No external resources registered for this compound

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 210783