Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | transient receptor potential cation channel, subfamily V, member 1 | Starlite/ChEMBL | No references |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | Type I phosphodiesterase / nucleotide pyrophosphatase family protein | 0.004 | 0.4211 | 0.4211 |
Leishmania major | DNA/RNA non-specific endonuclease-like protein | 0.0024 | 0.2216 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0034 | 0.3425 | 0.3425 |
Entamoeba histolytica | phosphatidylinositol-glycan biosynthesis class O protein, putative | 0.0006 | 0 | 0.5 |
Echinococcus multilocularis | ectonucleotide pyrophosphatase:phosphodiesterase | 0.004 | 0.4211 | 1 |
Trypanosoma cruzi | DNA/RNA non-specific endonuclease protein-like, putative | 0.0024 | 0.2216 | 0.5 |
Echinococcus granulosus | ectonucleotide pyrophosphatase:phosphodiesterase | 0.004 | 0.4211 | 1 |
Schistosoma mansoni | ectonucleotide pyrophosphatase/phosphodiesterase | 0.004 | 0.4211 | 0.4211 |
Schistosoma mansoni | ectonucleotide pyrophosphatase/phosphodiesterase | 0.004 | 0.4211 | 0.4211 |
Onchocerca volvulus | 0.0087 | 1 | 1 | |
Leishmania major | endonuclease G, putative | 0.0024 | 0.2216 | 1 |
Echinococcus multilocularis | ectonucleotide pyrophosphatase:phosphodiesterase | 0.004 | 0.4211 | 1 |
Loa Loa (eye worm) | thrombospondin type 1 domain-containing protein | 0.0087 | 1 | 1 |
Giardia lamblia | Phosphatidylinositol-glycan biosynthesis, class O protein | 0.0006 | 0 | 0.5 |
Echinococcus granulosus | ectonucleotide pyrophosphatase:phosphodiesterase | 0.004 | 0.4211 | 1 |
Echinococcus granulosus | ectonucleotide pyrophosphatase:phosphodiesterase | 0.004 | 0.4211 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0087 | 1 | 1 |
Echinococcus granulosus | ectonucleotide pyrophosphatase:phosphodiesterase | 0.004 | 0.4211 | 1 |
Echinococcus multilocularis | ectonucleotide pyrophosphatase:phosphodiesterase | 0.004 | 0.4211 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.004 | 0.4211 | 0.4211 |
Toxoplasma gondii | DNA/RNA non-specific endonuclease | 0.0024 | 0.2216 | 0.5 |
Entamoeba histolytica | phosphatidylinositol-glycan biosynthesis class O protein, putative | 0.0006 | 0 | 0.5 |
Echinococcus multilocularis | ectonucleotide pyrophosphatase:phosphodiesterase | 0.0034 | 0.3425 | 0.8134 |
Schistosoma mansoni | endonuclease related | 0.0024 | 0.2216 | 0.2216 |
Trypanosoma cruzi | endonuclease G, putative | 0.0024 | 0.2216 | 0.5 |
Echinococcus multilocularis | ectonucleotide pyrophosphatase:phosphodiesterase | 0.004 | 0.4211 | 1 |
Onchocerca volvulus | 0.004 | 0.4211 | 0.4211 | |
Trypanosoma brucei | endonuclease G, putative | 0.0024 | 0.2216 | 1 |
Brugia malayi | endonuclease G, mitochondrial precursor | 0.0024 | 0.2216 | 0.2216 |
Onchocerca volvulus | 0.004 | 0.4211 | 0.4211 | |
Loa Loa (eye worm) | hypothetical protein | 0.004 | 0.4211 | 0.4211 |
Mycobacterium leprae | hypothetical protein | 0.0006 | 0 | 0.5 |
Echinococcus granulosus | ectonucleotide pyrophosphatase:phosphodiesterase | 0.0034 | 0.3425 | 0.8134 |
Schistosoma mansoni | ectonucleotide pyrophosphatase/phosphodiesterase | 0.004 | 0.4211 | 0.4211 |
Schistosoma mansoni | ectonucleotide pyrophosphatase/phosphodiesterase | 0.004 | 0.4211 | 0.4211 |
Echinococcus multilocularis | ectonucleotide pyrophosphatase:phosphodiesterase | 0.004 | 0.4211 | 1 |
Mycobacterium ulcerans | hypothetical protein | 0.0006 | 0 | 0.5 |
Echinococcus granulosus | Endonuclease G | 0.0024 | 0.2216 | 0.5262 |
Loa Loa (eye worm) | hypothetical protein | 0.004 | 0.4211 | 0.4211 |
Echinococcus granulosus | ectonucleotide | 0.0034 | 0.3425 | 0.8134 |
Trypanosoma brucei | endonuclease G, putative | 0.0024 | 0.2216 | 1 |
Trypanosoma cruzi | DNA/RNA non-specific endonuclease protein-like, putative | 0.0024 | 0.2216 | 0.5 |
Trypanosoma brucei | endonuclease G, putative | 0.0024 | 0.2216 | 1 |
Echinococcus multilocularis | ectonucleotide pyrophosphatase:phosphodiesterase | 0.004 | 0.4211 | 1 |
Echinococcus multilocularis | Endonuclease G | 0.0024 | 0.2216 | 0.5262 |
Echinococcus granulosus | ectonucleotide pyrophosphatase:phosphodiesterase | 0.004 | 0.4211 | 1 |
Echinococcus multilocularis | ectonucleotide | 0.0034 | 0.3425 | 0.8134 |
Plasmodium falciparum | GPI ethanolamine phosphate transferase 3, putative | 0.0006 | 0 | 0.5 |
Trypanosoma cruzi | endonuclease G, putative | 0.0024 | 0.2216 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Inhibition (binding) | = 98 % | Inhibition of recombinant ATX (unknown origin) assessed as inhibition of hydrolysis of fluoregenic lysoPC analogue FS-3 at 10 uM | ChEMBL. | No reference |
Kd (binding) | = 1.1 uM | Activation of TRPV-1 channel (unknown origin) | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.