Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Rattus norvegicus | HMG-CoA reductase | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | tumor necrosis factor receptor related | 0.0231 | 0.3818 | 1 |
Leishmania major | 3-hydroxy-3-methylglutaryl-CoA reductase | 0.0165 | 0.2273 | 0.5 |
Echinococcus granulosus | hydroxymethylglutaryl coenzyme A reductase | 0.0165 | 0.2273 | 0.2273 |
Trichomonas vaginalis | 3-hydroxy-3-methylglutaryl-coenzyme A reductase, putative | 0.0078 | 0.0222 | 1 |
Trypanosoma cruzi | 3-hydroxy-3-methylglutaryl-CoA reductase | 0.0165 | 0.2273 | 0.5 |
Echinococcus granulosus | survival motor neuron protein 1 | 0.0253 | 0.4336 | 0.4336 |
Brugia malayi | hypothetical protein | 0.0253 | 0.4336 | 1 |
Echinococcus granulosus | neuropeptide receptor A26 | 0.0496 | 1 | 1 |
Echinococcus multilocularis | tumor necrosis factor receptor superfamily | 0.0231 | 0.3818 | 0.3818 |
Echinococcus multilocularis | neuropeptide receptor A26 | 0.0496 | 1 | 1 |
Trichomonas vaginalis | 3-hydroxy-3-methylglutaryl-coenzyme A reductase, putative | 0.0078 | 0.0222 | 1 |
Echinococcus multilocularis | nmda type glutamate receptor | 0.011 | 0.0981 | 0.0981 |
Treponema pallidum | amino acid ABC transporter, periplasmic binding protein (hisJ) | 0.0079 | 0.0259 | 0.5 |
Echinococcus multilocularis | Glutamate receptor, ionotropic kainate 3 | 0.011 | 0.0981 | 0.0981 |
Chlamydia trachomatis | arginine ABC transporter substrate-binding protein ArtJ | 0.0079 | 0.0259 | 0.5 |
Echinococcus multilocularis | neuropeptide s receptor | 0.0496 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0253 | 0.4336 | 1 |
Schistosoma mansoni | hydroxymethylglutaryl-CoA reductase (NADPH) | 0.0165 | 0.2273 | 0.5955 |
Echinococcus granulosus | nmda type glutamate receptor | 0.011 | 0.0981 | 0.0981 |
Mycobacterium ulcerans | hydroxymethylglutaryl-coenzyme a (HMG-CoA) reductase | 0.0165 | 0.2273 | 1 |
Echinococcus granulosus | tumor necrosis factor receptor superfamily | 0.0231 | 0.3818 | 0.3818 |
Treponema pallidum | amino acid ABC transporter, periplasmic binding protein | 0.0079 | 0.0259 | 0.5 |
Brugia malayi | Hydroxymethylglutaryl-coenzyme A reductase family protein | 0.0165 | 0.2273 | 0.5243 |
Loa Loa (eye worm) | hypothetical protein | 0.0165 | 0.2273 | 0.5243 |
Trichomonas vaginalis | 3-hydroxy-3-methylglutaryl-coenzyme A reductase, putative | 0.0078 | 0.0222 | 1 |
Echinococcus multilocularis | hydroxymethylglutaryl coenzyme A reductase | 0.0165 | 0.2273 | 0.2273 |
Echinococcus multilocularis | survival motor neuron protein 1 | 0.0253 | 0.4336 | 0.4336 |
Chlamydia trachomatis | glutamine binding protein | 0.0079 | 0.0259 | 0.5 |
Giardia lamblia | 3-hydroxy-3-methylglutaryl-coenzyme A reductase | 0.0078 | 0.0222 | 0.5 |
Trypanosoma cruzi | 3-hydroxy-3-methylglutaryl-CoA reductase, putative | 0.0165 | 0.2273 | 0.5 |
Mycobacterium tuberculosis | Probable glutamine-binding lipoprotein GlnH (GLNBP) | 0.0079 | 0.0259 | 0.5 |
Trypanosoma brucei | 3-hydroxy-3-methylglutaryl-CoA reductase, putative | 0.0165 | 0.2273 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 0.2 uM | Inhibition of HMG-CoA reductase activity in partially purified rat liver | ChEMBL. | 1992137 |
IC50 (binding) | = 0.2 uM | Inhibition of HMG-CoA reductase activity in partially purified rat liver | ChEMBL. | 1992137 |
Relative potency (functional) | = 35.5 | Relative potency against HMG-CoA reductase activity in partially purified rat liver | ChEMBL. | 1992137 |
Relative potency (functional) | = 35.5 | Relative potency against HMG-CoA reductase activity in partially purified rat liver | ChEMBL. | 1992137 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.