Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Echinococcus granulosus | matrix metallopeptidase 7 M10 family | matrix metallopeptidase 12 (macrophage elastase) | 470 aa | 467 aa | 32.1 % |
Echinococcus granulosus | matrix metallopeptidase 7 M10 family | matrix metallopeptidase 13 (collagenase 3) | 471 aa | 448 aa | 34.1 % |
Brugia malayi | Matrixin family protein | matrix metallopeptidase 1 (interstitial collagenase) | 403 aa | 401 aa | 27.7 % |
Echinococcus granulosus | matrix metallopeptidase 7 M10 family | matrix metallopeptidase 8 (neutrophil collagenase) | 467 aa | 467 aa | 33.4 % |
Echinococcus granulosus | matrix metallopeptidase 7 M10 family | matrix metallopeptidase 3 (stromelysin 1, progelatinase) | 477 aa | 431 aa | 34.6 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | matrix metallopeptidase 7 (M10 family) | 0.0795 | 1 | 0.5 |
Onchocerca volvulus | Matrix metalloproteinase homolog | 0.0432 | 0.3951 | 0.7317 |
Mycobacterium leprae | PROBABLE HYDROLASE | 0.0237 | 0.0707 | 0.5 |
Mycobacterium tuberculosis | Probable peptidoglycan hydrolase | 0.0237 | 0.0707 | 0.5 |
Loa Loa (eye worm) | matrixin family protein | 0.0558 | 0.6049 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0437 | 0.4042 | 0.6683 |
Onchocerca volvulus | Matrilysin homolog | 0.0519 | 0.54 | 1 |
Onchocerca volvulus | 0.0276 | 0.1356 | 0.2511 | |
Loa Loa (eye worm) | matrixin family protein | 0.0432 | 0.3951 | 0.6533 |
Loa Loa (eye worm) | hypothetical protein | 0.0282 | 0.1449 | 0.2395 |
Schistosoma mansoni | matrix metallopeptidase-7 (M10 family) | 0.0282 | 0.1449 | 1 |
Brugia malayi | Matrixin family protein | 0.0558 | 0.6049 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0237 | 0.0707 | 0.1169 |
Brugia malayi | ADAM-TS Spacer 1 family protein | 0.0437 | 0.4042 | 0.6683 |
Brugia malayi | Matrix metalloprotease, N-terminal domain containing protein | 0.0237 | 0.0707 | 0.1169 |
Mycobacterium ulcerans | hydrolase | 0.0237 | 0.0707 | 0.5 |
Brugia malayi | Hemopexin family protein | 0.0276 | 0.1356 | 0.2241 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 1 nM | AlphaScreen Assay | BINDINGDB. | No reference |
IC50 (binding) | = 2 nM | AlphaScreen Assay | BINDINGDB. | No reference |
IC50 (binding) | = 2 nM | AlphaScreen Assay | BINDINGDB. | No reference |
IC50 (binding) | < 5.1 nM | In Vitro Fluorescence Assay | BINDINGDB. | No reference |
IC50 (binding) | = 20 nM | Shift AlphaScreen Assay | BINDINGDB. | No reference |
IC50 (binding) | = 26 nM | In Vitro Fluorescence Assay | BINDINGDB. | No reference |
IC50 (binding) | = 326 nM | Shift AlphaScreen Assay | BINDINGDB. | No reference |
IC50 (binding) | = 439 nM | In Vitro Fluorescence Assay | BINDINGDB. | No reference |
IC50 (binding) | = 704 nM | In Vitro Fluorescence Assay | BINDINGDB. | No reference |
IC50 (binding) | = 897 nM | In Vitro Fluorescence Assay | BINDINGDB. | No reference |
IC50 (binding) | = 4189 nM | In Vitro Fluorescence Assay | BINDINGDB. | No reference |
IC50 (binding) | = 7990 nM | In Vitro Fluorescence Assay | BINDINGDB. | No reference |
IC50 (binding) | = 15342 nM | In Vitro Fluorescence Assay | BINDINGDB. | No reference |
IC50 (binding) | > 100000 nM | In Vitro Fluorescence Assay | BINDINGDB. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.