Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trichomonas vaginalis | glucosylceramidase, putative | 0.0253 | 0.4692 | 1 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0175 | 0.2202 | 0.4494 |
Brugia malayi | O-Glycosyl hydrolase family 30 protein | 0.0253 | 0.4692 | 0.9718 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0253 | 0.4692 | 1 |
Giardia lamblia | Ceramide glucosyltransferase | 0.0106 | 0 | 0.5 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0166 | 0.1916 | 0.3863 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0175 | 0.2202 | 0.4494 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0253 | 0.4692 | 1 |
Loa Loa (eye worm) | alpha-L-fucosidase | 0.0254 | 0.471 | 1 |
Mycobacterium ulcerans | alpha-L-fucosidase | 0.042 | 1 | 0.5 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0166 | 0.1916 | 0.3863 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0253 | 0.4692 | 1 |
Echinococcus multilocularis | fucosidase, alpha L 1, tissue | 0.042 | 1 | 1 |
Loa Loa (eye worm) | O-glycosyl hydrolase family 30 protein | 0.0253 | 0.4692 | 0.9718 |
Leishmania major | lanosterol synthase, putative | 0.0125 | 0.0592 | 0.5 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0166 | 0.1916 | 0.3863 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0166 | 0.1916 | 0.3863 |
Trypanosoma cruzi | lanosterol synthase, putative | 0.0144 | 0.1221 | 0.5 |
Brugia malayi | Alpha-L-fucosidase family protein | 0.0254 | 0.471 | 1 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0253 | 0.4692 | 1 |
Trypanosoma cruzi | lanosterol synthase, putative | 0.0144 | 0.1221 | 0.5 |
Schistosoma mansoni | alpha-l-fucosidase | 0.0254 | 0.471 | 1 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0166 | 0.1916 | 0.3863 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0166 | 0.1916 | 0.3863 |
Trypanosoma brucei | lanosterol synthase | 0.0144 | 0.1221 | 0.5 |
Onchocerca volvulus | Ceramide glucosyltransferase homolog | 0.0234 | 0.4076 | 1 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0166 | 0.1916 | 0.3863 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0253 | 0.4692 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
clogP | = 4.6 | Calculated partition coefficient (clogP) | ChEMBL. | 15203135 |
IC50 (functional) | NT 0 uM | Inhibition of [3H]-Arachidonic acid production by stimulated HL60 (human leukaemia) cells; NT=Not tested. | ChEMBL. | 15203135 |
IC50 (binding) | = 34 uM | In vitro inhibition of human recombinant cytosolic phsopholipase A2 (c-PLA2). | ChEMBL. | 15203135 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.