TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 379.126 | Formula: C17H16F3N5O2
H donors: 2 H acceptors: 3 LogP: 2.63 Rotable bonds: 6
Rule of 5 violations (Lipinski): 0
SMILES: CCOc1ccc2c(c1)ncc(c2)c1nn(c(c1C(=O)N)N)CC(F)(F)F
InChi: InChI=1S/C17H16F3N5O2/c1-2-27-11-4-3-9-5-10(7-23-12(9)6-11)14-13(16(22)26)15(21)25(24-14)8-17(18,19)20/h3-7H,2,8,21H2,1H3,(H2,22,26)
InChiKey: QDNYKPYYLWQMPU-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	SRC proto-oncogene, non-receptor tyrosine kinase		References
Toxoplasma gondii	calcium-dependent protein kinase CDPK3		References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Echinococcus multilocularis	tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase	Get druggable targets OG5_127750	All targets in OG5_127750
Theileria parva	calcium-dependent protein kinase, putative	Get druggable targets OG5_126600	All targets in OG5_126600
Echinococcus granulosus	calcium:calmodulin dependent protein kinase type	Get druggable targets OG5_126600	All targets in OG5_126600
Echinococcus multilocularis	calcium:calmodulin dependent protein kinase type	Get druggable targets OG5_126600	All targets in OG5_126600
Loa Loa (eye worm)	CAMK/CAMK2 protein kinase	Get druggable targets OG5_126600	All targets in OG5_126600
Schistosoma japonicum	Calcium/calmodulin-dependent protein kinase type II alpha chain, putative	Get druggable targets OG5_126600	All targets in OG5_126600
Echinococcus multilocularis	tyrosine protein kinase Srms	Get druggable targets OG5_127750	All targets in OG5_127750
Neospora caninum	hypothetical protein	Get druggable targets OG5_126600	All targets in OG5_126600
Schistosoma mansoni	protein kinase	Get druggable targets OG5_126600	All targets in OG5_126600
Cryptosporidium parvum	calcium/calmodulin dependent protein kinase with a kinas domain and 4 calmodulin-like EF hands	Get druggable targets OG5_126600	All targets in OG5_126600
Echinococcus granulosus	calcium:calmodulin dependent protein kinase type 1	Get druggable targets OG5_126600	All targets in OG5_126600
Schistosoma japonicum	ko:K04515 calcium/calmodulin-dependent protein kinase (CaM kinase) II, putative	Get druggable targets OG5_126600	All targets in OG5_126600
Theileria parva	calmodulin-domain protein kinase, putative	Get druggable targets OG5_126600	All targets in OG5_126600
Entamoeba histolytica	protein kinase, putative	Get druggable targets OG5_126600	All targets in OG5_126600
Plasmodium knowlesi	calcium-dependent protein kinase 3, putative	Get druggable targets OG5_126600	All targets in OG5_126600
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_126600	All targets in OG5_126600
Plasmodium falciparum	calcium-dependent protein kinase 4	Get druggable targets OG5_126600	All targets in OG5_126600
Cryptosporidium parvum	calmodulin-domain protein kinase 1, putative	Get druggable targets OG5_126600	All targets in OG5_126600
Neospora caninum	hypothetical protein	Get druggable targets OG5_126600	All targets in OG5_126600
Plasmodium falciparum	calcium-dependent protein kinase 5	Get druggable targets OG5_126600	All targets in OG5_126600
Echinococcus multilocularis	tyrosine protein kinase Fyn	Get druggable targets OG5_127750	All targets in OG5_127750
Echinococcus granulosus	tyrosine protein kinase Blk	Get druggable targets OG5_127750	All targets in OG5_127750
Plasmodium knowlesi	calcium-dependent protein kinase 4, putative	Get druggable targets OG5_126600	All targets in OG5_126600
Plasmodium berghei	calcium-dependent protein kinase 3	Get druggable targets OG5_126600	All targets in OG5_126600
Schistosoma japonicum	Proto-oncogene tyrosine-protein kinase FGR, putative	Get druggable targets OG5_127750	All targets in OG5_127750
Echinococcus multilocularis	calcium:calmodulin dependent protein kinase type	Get druggable targets OG5_126600	All targets in OG5_126600
Entamoeba histolytica	protein kinase, putative	Get druggable targets OG5_127750	All targets in OG5_127750
Entamoeba histolytica	protein kinase, putative	Get druggable targets OG5_126600	All targets in OG5_126600
Brugia malayi	SRC-1	Get druggable targets OG5_127750	All targets in OG5_127750
Schistosoma japonicum	Calcium/calmodulin-dependent protein kinase type II delta chain, putative	Get druggable targets OG5_126600	All targets in OG5_126600
Trypanosoma congolense	protein kinase, putative	Get druggable targets OG5_126600	All targets in OG5_126600
Loa Loa (eye worm)	calcium/calmodulin-dependent protein kinase ID	Get druggable targets OG5_126600	All targets in OG5_126600
Babesia bovis	calcium-dependent protein kinase 4	Get druggable targets OG5_126600	All targets in OG5_126600
Trypanosoma brucei gambiense	protein kinase, putative	Get druggable targets OG5_126600	All targets in OG5_126600
Leishmania donovani	protein kinase, putative	Get druggable targets OG5_126600	All targets in OG5_126600
Cryptosporidium parvum	calcium/calmodulin dependent protein kinase with a kinase domain and 4 calmodulin like EF hands	Get druggable targets OG5_126600	All targets in OG5_126600
Schistosoma japonicum	Proto-oncogene tyrosine-protein kinase FYN, putative	Get druggable targets OG5_127750	All targets in OG5_127750
Neospora caninum	Calmodulin-like domain protein kinase isoenzyme gamma, related	Get druggable targets OG5_126600	All targets in OG5_126600
Plasmodium yoelii	calcium-dependent protein kinase-3	Get druggable targets OG5_126600	All targets in OG5_126600
Neospora caninum	hypothetical protein	Get druggable targets OG5_126600	All targets in OG5_126600
Echinococcus multilocularis	proto oncogene tyrosine protein kinase LCK	Get druggable targets OG5_127750	All targets in OG5_127750
Candida albicans	Serine-threonine protein kinase similar to S. cerevisiae CMK2 (YOL016C) calcium/calmodulin-dependent protein kinase	Get druggable targets OG5_126600	All targets in OG5_126600
Echinococcus granulosus	tyrosine protein kinase HCK	Get druggable targets OG5_127750	All targets in OG5_127750
Schistosoma japonicum	Calcium/calmodulin-dependent protein kinase type 1, putative	Get druggable targets OG5_126600	All targets in OG5_126600
Plasmodium knowlesi	calcium-dependent protein kinase 1, putative	Get druggable targets OG5_126600	All targets in OG5_126600
Schistosoma mansoni	serine/threonine protein kinase	Get druggable targets OG5_126600	All targets in OG5_126600
Plasmodium berghei	calcium-dependent protein kinase 1	Get druggable targets OG5_126600	All targets in OG5_126600
Echinococcus granulosus	calcium dependent protein kinase	Get druggable targets OG5_126600	All targets in OG5_126600
Schistosoma japonicum	Proto-oncogene tyrosine-protein kinase Yrk, putative	Get druggable targets OG5_127750	All targets in OG5_127750
Plasmodium knowlesi	calcium-dependent protein kinase 5, putative	Get druggable targets OG5_126600	All targets in OG5_126600
Echinococcus granulosus	tyrosine protein kinase Src64B	Get druggable targets OG5_127750	All targets in OG5_127750
Leishmania infantum	protein kinase, putative	Get druggable targets OG5_126600	All targets in OG5_126600
Plasmodium yoelii	calcium-dept. protein kinase	Get druggable targets OG5_126600	All targets in OG5_126600
Echinococcus granulosus	calcium:calmodulin dependent protein kinase type	Get druggable targets OG5_126600	All targets in OG5_126600
Trypanosoma brucei	calcium/calmodulin-dependent protein kinase, putative	Get druggable targets OG5_126600	All targets in OG5_126600
Toxoplasma gondii	calcium-dependent protein kinase CDPK3	Get druggable targets OG5_126600	All targets in OG5_126600
Echinococcus multilocularis	calcium dependent protein kinase	Get druggable targets OG5_126600	All targets in OG5_126600
Plasmodium berghei	calcium-dependent protein kinase 5	Get druggable targets OG5_126600	All targets in OG5_126600
Schistosoma japonicum	Proto-oncogene tyrosine-protein kinase FYN, putative	Get druggable targets OG5_127750	All targets in OG5_127750
Plasmodium yoelii	calmodulin-domain protein kinase	Get druggable targets OG5_126600	All targets in OG5_126600
Echinococcus multilocularis	tyrosine protein kinase Blk	Get druggable targets OG5_127750	All targets in OG5_127750
Cryptosporidium hominis	CDPK2	Get druggable targets OG5_126600	All targets in OG5_126600
Echinococcus multilocularis	tyrosine protein kinase Fyn	Get druggable targets OG5_127750	All targets in OG5_127750
Cryptosporidium parvum	calcium/calmodulin dependent protein kinase with a kinase domain and 4 calmodulin like EF hands	Get druggable targets OG5_126600	All targets in OG5_126600
Echinococcus multilocularis	tyrosine protein kinase lyn tyrosine protein kinase blk	Get druggable targets OG5_127750	All targets in OG5_127750
Loa Loa (eye worm)	TK protein kinase	Get druggable targets OG5_127750	All targets in OG5_127750
Echinococcus multilocularis	calcium:calmodulin dependent protein kinase type	Get druggable targets OG5_126600	All targets in OG5_126600
Trypanosoma congolense	protein kinase, putative	Get druggable targets OG5_126600	All targets in OG5_126600
Cryptosporidium hominis	calcium-dependent protein kinase	Get druggable targets OG5_126600	All targets in OG5_126600
Echinococcus granulosus	tyrosine protein kinase Fyn	Get druggable targets OG5_127750	All targets in OG5_127750
Echinococcus granulosus	tyrosine protein kinase Src42A	Get druggable targets OG5_127750	All targets in OG5_127750
Echinococcus granulosus	tyrosine protein kinase Src42A	Get druggable targets OG5_127750	All targets in OG5_127750
Brugia malayi	Calcium/calmodulin-dependent protein kinase type II alpha chain	Get druggable targets OG5_126600	All targets in OG5_126600
Loa Loa (eye worm)	SRC-1	Get druggable targets OG5_127750	All targets in OG5_127750
Schistosoma japonicum	ko:K08794 calcium/calmodulin-dependent protein kinase I, putative	Get druggable targets OG5_126600	All targets in OG5_126600
Loa Loa (eye worm)	TK protein kinase	Get druggable targets OG5_127750	All targets in OG5_127750
Plasmodium yoelii	Plasmodium falciparum CDPK2 protein	Get druggable targets OG5_126600	All targets in OG5_126600
Candida albicans	Serine-threonine protein kinase similar to S. cerevisiae CMK2 (YOL016C) calcium/calmodulin-dependent protein kinase	Get druggable targets OG5_126600	All targets in OG5_126600
Echinococcus granulosus	tyrosine protein kinase Fyn	Get druggable targets OG5_127750	All targets in OG5_127750
Leishmania mexicana	protein kinase, putative	Get druggable targets OG5_126600	All targets in OG5_126600
Echinococcus multilocularis	calcium:calmodulin dependent protein kinase type	Get druggable targets OG5_126600	All targets in OG5_126600
Plasmodium falciparum	calcium-dependent protein kinase 3	Get druggable targets OG5_126600	All targets in OG5_126600
Cryptosporidium hominis	calmodulin-domain protein kinase 1	Get druggable targets OG5_126600	All targets in OG5_126600
Echinococcus granulosus	tyrosine kinase\|tyrosine protein kinase Fyn	Get druggable targets OG5_127750	All targets in OG5_127750
Schistosoma mansoni	protein kinase	Get druggable targets OG5_126600	All targets in OG5_126600
Leishmania braziliensis	protein kinase, putative	Get druggable targets OG5_126600	All targets in OG5_126600
Plasmodium vivax	calcium-dependent protein kinase 3, putative	Get druggable targets OG5_126600	All targets in OG5_126600
Echinococcus granulosus	tyrosine protein kinase Fyn	Get druggable targets OG5_127750	All targets in OG5_127750
Plasmodium falciparum	calcium-dependent protein kinase 2	Get druggable targets OG5_126600	All targets in OG5_126600
Echinococcus granulosus	tyrosine kinase	Get druggable targets OG5_127750	All targets in OG5_127750
Schistosoma japonicum	ko:K08892 fyn-related kinase, putative	Get druggable targets OG5_127750	All targets in OG5_127750
Plasmodium falciparum	calcium-dependent protein kinase 1	Get druggable targets OG5_126600	All targets in OG5_126600
Brugia malayi	protein-tyrosine kinase	Get druggable targets OG5_127750	All targets in OG5_127750
Echinococcus multilocularis	tyrosine protein kinase Fgr	Get druggable targets OG5_127750	All targets in OG5_127750
Toxoplasma gondii	calcium-dependent protein kinase CDPK2B	Get druggable targets OG5_126600	All targets in OG5_126600
Schistosoma mansoni	tyrosine kinase	Get druggable targets OG5_127750	All targets in OG5_127750
Echinococcus granulosus	calcium:calmodulin dependent protein kinase type	Get druggable targets OG5_126600	All targets in OG5_126600
Neospora caninum	Calcium-dependent protein kinase 2, related	Get druggable targets OG5_126600	All targets in OG5_126600
Schistosoma japonicum	ko:K05703 proto-oncogene tyrosine-protein kinase Fyn, putative	Get druggable targets OG5_127750	All targets in OG5_127750
Echinococcus multilocularis	tyrosine protein kinase Src42A	Get druggable targets OG5_127750	All targets in OG5_127750
Echinococcus multilocularis	tyrosine protein kinase HCK	Get druggable targets OG5_127750	All targets in OG5_127750
Echinococcus multilocularis	tyrosine protein kinase Fyn	Get druggable targets OG5_127750	All targets in OG5_127750
Echinococcus granulosus	proto oncogene tyrosine protein kinase LCK	Get druggable targets OG5_127750	All targets in OG5_127750
Echinococcus multilocularis	tyrosine protein kinase Src64B	Get druggable targets OG5_127750	All targets in OG5_127750
Echinococcus multilocularis	tyrosine protein kinase Src42A	Get druggable targets OG5_127750	All targets in OG5_127750
Schistosoma mansoni	tyrosine kinase	Get druggable targets OG5_127750	All targets in OG5_127750
Plasmodium vivax	calcium-dependent protein kinase 1, putative	Get druggable targets OG5_126600	All targets in OG5_126600
Trichomonas vaginalis	CAMK family protein kinase	Get druggable targets OG5_126600	All targets in OG5_126600
Schistosoma mansoni	protein kinase	Get druggable targets OG5_126600	All targets in OG5_126600
Schistosoma japonicum	Calcium/calmodulin-dependent protein kinase type II beta chain, putative	Get druggable targets OG5_126600	All targets in OG5_126600
Toxoplasma gondii	calcium-dependent protein kinase CDPK2A	Get druggable targets OG5_126600	All targets in OG5_126600
Plasmodium vivax	calcium-dependent protein kinase 4, putative	Get druggable targets OG5_126600	All targets in OG5_126600
Plasmodium vivax	calcium-dependent protein kinase, putative	Get druggable targets OG5_126600	All targets in OG5_126600
Echinococcus granulosus	tyrosine protein kinase Lyn	Get druggable targets OG5_127750	All targets in OG5_127750
Echinococcus multilocularis	tyrosine protein kinase Fyn	Get druggable targets OG5_127750	All targets in OG5_127750
Leishmania major	protein kinase, putative	Get druggable targets OG5_126600	All targets in OG5_126600
Brugia malayi	Cam kinase protein 1	Get druggable targets OG5_126600	All targets in OG5_126600
Babesia bovis	protein kinase domain containing protein	Get druggable targets OG5_126600	All targets in OG5_126600
Cryptosporidium hominis	hypothetical protein	Get druggable targets OG5_126600	All targets in OG5_126600
Echinococcus granulosus	3'partial\|tyrosine protein kinase Fgr	Get druggable targets OG5_127750	All targets in OG5_127750
Plasmodium berghei	calcium-dependent protein kinase 4	Get druggable targets OG5_126600	All targets in OG5_126600

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0045	0.991	1
Brugia malayi	SH2 domain containing protein	0.0006	0.0309	0.0312
Brugia malayi	Protein kinase domain containing protein	0.0006	0.0309	0.0312
Echinococcus granulosus	calcium:calmodulin dependent protein kinase type	0.0018	0.3376	0.3376
Entamoeba histolytica	protein kinase, putative	0.0005	0.009	0.0116
Echinococcus multilocularis	calcium:calmodulin dependent protein kinase type	0.0018	0.3376	0.3407
Entamoeba histolytica	protein kinase, putative	0.0036	0.7736	1
Brugia malayi	SRC-1	0.0045	0.991	1
Schistosoma mansoni	serine/threonine protein kinase	0.0006	0.0282	0.0284
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0045	0.991	0.991
Echinococcus multilocularis	tyrosine protein kinase shark	0.0006	0.0309	0.0312
Plasmodium falciparum	calcium-dependent protein kinase 4	0.0018	0.3379	0.5
Echinococcus granulosus	calcium dependent protein kinase	0.0018	0.3289	0.3289
Brugia malayi	protein-tyrosine kinase	0.0041	0.8837	0.8917
Loa Loa (eye worm)	CAMK/CAMK2 protein kinase	0.0018	0.3376	0.3407
Schistosoma mansoni	tyrosine kinase	0.0006	0.0309	0.0312
Brugia malayi	Variant SH3 domain containing protein	0.0009	0.1074	0.1083
Schistosoma mansoni	protein kinase	0.0018	0.3376	0.3407
Schistosoma mansoni	adapter molecule crk	0.0009	0.1074	0.1083
Loa Loa (eye worm)	TK protein kinase	0.0041	0.8837	0.8917
Loa Loa (eye worm)	hypothetical protein	0.0009	0.1074	0.1083
Schistosoma mansoni	tyrosine kinase	0.0045	0.991	1
Onchocerca volvulus		0.0005	0.0063	0.2024
Schistosoma mansoni	tyrosine kinase	0.001	0.1383	0.1395
Echinococcus multilocularis	tyrosine protein kinase ABL1	0.0006	0.0309	0.0312
Schistosoma mansoni	nck2/grb4	0.0009	0.1074	0.1083
Schistosoma mansoni	proto-oncogene tyrosine-protein kinase src	0.001	0.1383	0.1395
Echinococcus granulosus	tyrosine protein kinase Src64B	0.0045	0.991	0.991
Plasmodium vivax	calcium-dependent protein kinase, putative	0.0018	0.3379	0.5
Echinococcus multilocularis	tyrosine protein kinase lyn tyrosine protein kinase blk	0.0045	0.991	1
Echinococcus granulosus	tyrosine kinase	0.0041	0.8837	0.8837
Loa Loa (eye worm)	SRC-1	0.0045	0.991	1
Echinococcus granulosus	tyrosine protein kinase Blk	0.0041	0.8837	0.8837
Echinococcus granulosus	tyrosine protein kinase Srms	0.0006	0.0309	0.0309
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0045	0.991	0.991
Echinococcus multilocularis	tyrosine protein kinase Src64B	0.0045	0.991	1
Toxoplasma gondii	calcium-dependent protein kinase CDPK2B	0.0018	0.3379	0.5
Loa Loa (eye worm)	TK/FER protein kinase	0.0006	0.0309	0.0312
Echinococcus multilocularis	calcium dependent protein kinase	0.0018	0.3289	0.3319
Entamoeba histolytica	SH2-protein kinase domain containing protein	0.0006	0.0309	0.04
Echinococcus multilocularis	tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase	0.0045	0.991	1
Plasmodium falciparum	calcium-dependent protein kinase 2	0.0018	0.3379	0.5
Echinococcus granulosus	NCK adaptor protein	0.0009	0.1074	0.1074
Plasmodium falciparum	calcium-dependent protein kinase 5	0.0018	0.3379	0.5
Echinococcus multilocularis	calcium:calmodulin dependent protein kinase type	0.0018	0.3376	0.3407
Onchocerca volvulus		0.0006	0.0309	1
Echinococcus granulosus	tyrosine protein kinase shark	0.0006	0.0309	0.0309
Echinococcus granulosus	tyrosine protein kinase ABL1	0.0006	0.0309	0.0309
Plasmodium vivax	calcium-dependent protein kinase 3, putative	0.0018	0.3379	0.5
Toxoplasma gondii	calcium-dependent protein kinase CDPK2A	0.0018	0.3379	0.5
Onchocerca volvulus		0.0006	0.0309	1
Schistosoma mansoni	protein kinase	0.0018	0.3376	0.3407
Schistosoma mansoni	serine/threonine protein kinase	0.0018	0.3376	0.3407
Schistosoma mansoni	growth factor receptor-bound protein	0.0009	0.1074	0.1083
Brugia malayi	Protein kinase domain containing protein	0.0006	0.0309	0.0312
Echinococcus granulosus	tyrosine protein kinase Src42A	0.004	0.8528	0.8528
Loa Loa (eye worm)	TK/FER protein kinase	0.0006	0.0309	0.0312
Echinococcus multilocularis	proto oncogene tyrosine protein kinase LCK	0.0045	0.991	1
Onchocerca volvulus		0.0006	0.0309	1
Loa Loa (eye worm)	hypothetical protein	0.0018	0.3376	0.3407
Echinococcus granulosus	tyrosine protein kinase Src42A	0.0045	0.991	0.991
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0045	0.991	1
Trichomonas vaginalis	CAMK family protein kinase	0.0018	0.3376	0.5
Echinococcus multilocularis	calcium:calmodulin dependent protein kinase type	0.0018	0.3376	0.3407
Onchocerca volvulus		0.0006	0.0309	1
Echinococcus granulosus	tyrosine kinase\|tyrosine protein kinase Fyn	0.0041	0.8837	0.8837
Echinococcus granulosus	calcium:calmodulin dependent protein kinase type 1	0.0018	0.3376	0.3376
Brugia malayi	Calcium/calmodulin-dependent protein kinase type II alpha chain	0.0018	0.3376	0.3407
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0045	0.991	1
Plasmodium vivax	calcium-dependent protein kinase 1, putative	0.0018	0.3379	0.5
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0045	0.991	0.991
Echinococcus multilocularis	tyrosine protein kinase HCK	0.0036	0.7736	0.7806
Schistosoma mansoni	growth factor receptor-bound protein	0.0009	0.1074	0.1083
Echinococcus granulosus	tyrosine kinase	0.0006	0.0309	0.0309
Loa Loa (eye worm)	TK/FER protein kinase	0.0006	0.0309	0.0312
Entamoeba histolytica	protein kinase, putative	0.0018	0.3376	0.4365
Echinococcus multilocularis	tyrosine protein kinase Src42A	0.004	0.8528	0.8605
Brugia malayi	Tyrosine-protein kinase abl-1	0.001	0.1383	0.1395
Loa Loa (eye worm)	TK/FER protein kinase	0.0006	0.0309	0.0312
Echinococcus granulosus	calcium:calmodulin dependent protein kinase type	0.0018	0.3376	0.3376
Loa Loa (eye worm)	TK/FER protein kinase	0.0006	0.0309	0.0312
Brugia malayi	Protein kinase domain containing protein	0.0006	0.0309	0.0312
Plasmodium falciparum	calcium-dependent protein kinase 3	0.0018	0.3379	0.5
Loa Loa (eye worm)	TK/FER protein kinase	0.0006	0.0309	0.0312
Loa Loa (eye worm)	hypothetical protein	0.0006	0.0309	0.0312
Plasmodium vivax	calcium-dependent protein kinase 4, putative	0.0018	0.3379	0.5
Onchocerca volvulus		0.0006	0.0309	1
Echinococcus multilocularis	growth factor receptor bound protein 2	0.0009	0.1074	0.1083
Echinococcus multilocularis	tyrosine protein kinase Abl	0.001	0.1383	0.1395
Brugia malayi	Cam kinase protein 1	0.0018	0.3376	0.3407
Echinococcus multilocularis	tyrosine protein kinase Btk29A	0.001	0.1383	0.1395
Echinococcus multilocularis	tyrosine protein kinase Fgr	0.0045	0.991	1
Schistosoma mansoni	protein kinase	0.0018	0.3376	0.3407
Echinococcus multilocularis	c src tyrosine kinase	0.001	0.1383	0.1395
Echinococcus granulosus	tyrosine protein kinase Fps85D	0.0006	0.0309	0.0309
Loa Loa (eye worm)	calcium/calmodulin-dependent protein kinase ID	0.0018	0.3376	0.3407
Onchocerca volvulus		0.0006	0.0309	1
Toxoplasma gondii	calcium-dependent protein kinase CDPK3	0.0018	0.3379	0.5
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0041	0.8837	0.8917
Echinococcus multilocularis	tyrosine kinase	0.0006	0.0309	0.0312
Loa Loa (eye worm)	TK protein kinase	0.0036	0.7736	0.7806
Echinococcus multilocularis	tyrosine protein kinase Fps85D	0.0006	0.0309	0.0312
Plasmodium falciparum	calcium-dependent protein kinase 1	0.0018	0.3379	0.5
Schistosoma mansoni	proto-oncogene tyrosine-protein kinase abl1	0.0009	0.1074	0.1083
Brugia malayi	Variant SH3 domain containing protein	0.0009	0.1074	0.1083
Echinococcus multilocularis	calcium:calmodulin dependent protein kinase type	0.0018	0.3376	0.3407
Brugia malayi	SH2 domain containing protein	0.0006	0.0309	0.0312
Echinococcus granulosus	3'partial\|tyrosine protein kinase Fgr	0.0045	0.991	0.991
Echinococcus granulosus	tyrosine protein kinase Btk29A	0.001	0.1383	0.1383
Echinococcus granulosus	calcium:calmodulin dependent protein kinase type	0.0018	0.3376	0.3376
Loa Loa (eye worm)	TK/FER protein kinase	0.0006	0.0309	0.0312
Echinococcus granulosus	c src tyrosine kinase	0.001	0.1383	0.1383
Echinococcus multilocularis	tyrosine protein kinase Srms	0.0041	0.8837	0.8917
Echinococcus granulosus	proto oncogene tyrosine protein kinase LCK	0.0045	0.991	0.991
Echinococcus granulosus	growth factor receptor bound protein 2	0.0009	0.1074	0.1074
Brugia malayi	Sex muscle abnormal protein 5	0.0009	0.1074	0.1083
Echinococcus granulosus	tyrosine protein kinase HCK	0.0036	0.7736	0.7736
Loa Loa (eye worm)	variant SH3 domain-containing protein	0.0009	0.1074	0.1083
Loa Loa (eye worm)	TK/ABL protein kinase	0.0006	0.0309	0.0312
Loa Loa (eye worm)	TK/FER protein kinase	0.0006	0.0309	0.0312
Leishmania major	protein kinase, putative	0.0018	0.3376	0.5
Brugia malayi	Protein kinase domain containing protein	0.0006	0.0309	0.0312
Brugia malayi	Protein kinase domain containing protein	0.0006	0.0309	0.0312
Echinococcus multilocularis	tyrosine protein kinase Blk	0.0041	0.8837	0.8917
Schistosoma mansoni	tyrosine kinase	0.001	0.1383	0.1395
Echinococcus multilocularis	tyrosine protein kinase Src42A	0.0045	0.991	1
Schistosoma mansoni	tyrosine kinase	0.0045	0.991	1
Entamoeba histolytica	protein kinase, putative	0.0018	0.3376	0.4365
Echinococcus multilocularis	NCK adaptor protein	0.0009	0.1074	0.1083
Loa Loa (eye worm)	TK/FER protein kinase	0.0006	0.0309	0.0312
Loa Loa (eye worm)	sex muscle abnormal protein 5	0.0009	0.1074	0.1083
Schistosoma mansoni	tyrosine kinase	0.0006	0.0309	0.0312
Brugia malayi	hypothetical protein	0.0006	0.0309	0.0312
Loa Loa (eye worm)	TK/FER protein kinase	0.0006	0.0309	0.0312
Trypanosoma brucei	calcium/calmodulin-dependent protein kinase, putative	0.0018	0.3376	0.5
Entamoeba histolytica	SH2-protein kinase domain containing protein	0.0005	0.009	0.0116

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	= 13 nM	Inhibition of Toxoplasma gondii CDPK1 assessed as ATP consumption using (Biotin-C6-PLARTLSVAGLPGKK) as substrate after 90 mins by luciferase reporter assay	ChEMBL.	26693272
IC50 (binding)	= 0.013 uM	Inhibition of recombinant Toxoplasma gondii CDPK1 using Syntide 2 as substrate assessed as decrease in depletion of ATP after 90 mins by Kinase glo luciferase assay	LITERATURE.	27780638
IC50 (binding)	> 10 uM	Inhibition of human SRC using Ac-EIYGEFKKK as substrate after 90 mins by Kinase glo luciferase assay	LITERATURE.	27780638

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL3769900

Bibliographic References

2 literature references were collected for this gene.

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Detailed information for compound 2113126