Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Rattus norvegicus | Glutamate NMDA receptor | Starlite/ChEMBL | References |
Sus scrofa | D-amino-acid oxidase | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Candida albicans | similar to putative d-amino acid oxidase | D-amino-acid oxidase | 347 aa | 390 aa | 23.3 % |
Onchocerca volvulus | Unconventional prefoldin RPB5 interactor 1 homolog | D-amino-acid oxidase | 347 aa | 351 aa | 30.8 % |
Mycobacterium ulcerans | D-amino acid oxidase Aao | D-amino-acid oxidase | 347 aa | 376 aa | 25.5 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Toxoplasma gondii | histone lysine methyltransferase SET/SUV39 | 0.0035 | 0.012 | 0.5 |
Brugia malayi | Pre-SET motif family protein | 0.0243 | 0.8628 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0193 | 0.6569 | 0.9881 |
Echinococcus granulosus | geminin | 0.0193 | 0.6569 | 1 |
Mycobacterium leprae | PROBABLE D-AMINO ACID OXIDASE AAO | 0.0195 | 0.6646 | 0.5 |
Plasmodium vivax | SET domain protein, putative | 0.0035 | 0.012 | 0.5 |
Loa Loa (eye worm) | pre-SET domain-containing protein family protein | 0.0243 | 0.8628 | 1 |
Mycobacterium tuberculosis | Probable D-amino acid oxidase Aao | 0.0179 | 0.5984 | 0.5 |
Mycobacterium ulcerans | D-amino acid oxidase Aao | 0.0195 | 0.6646 | 0.5 |
Echinococcus multilocularis | histone lysine methyltransferase setb histone lysine methyltransferase eggless | 0.0035 | 0.012 | 0.0183 |
Trichomonas vaginalis | set domain proteins, putative | 0.0277 | 1 | 0.5 |
Schistosoma mansoni | d-amino acid oxidase | 0.0195 | 0.6646 | 1 |
Echinococcus multilocularis | geminin | 0.0193 | 0.6569 | 1 |
Echinococcus granulosus | histone lysine methyltransferase setb | 0.0035 | 0.012 | 0.0183 |
Echinococcus granulosus | 5'partial|histone lysine N methyltransferase SETDB2 | 0.0034 | 0.0068 | 0.0103 |
Echinococcus multilocularis | histone lysine N methyltransferase SETMAR | 0.0035 | 0.012 | 0.0183 |
Loa Loa (eye worm) | hypothetical protein | 0.0195 | 0.6646 | 0.7671 |
Schistosoma mansoni | hypothetical protein | 0.0193 | 0.6569 | 0.9881 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 2.2 uM | Displacement of [3H]-DCKA at N-methyl-D-aspartate glutamate receptor 1 | ChEMBL. | 9357535 |
IC50 (binding) | = 2.2 uM | Displacement of [3H]-DCKA at N-methyl-D-aspartate glutamate receptor 1 | ChEMBL. | 9357535 |
IC50 (binding) | = 6.7 uM | Inhibition of DAAO in porcine kidney homogenate using D-alanine as substrate assessed as pyruvate production incubated for 5 mins by microplate reader analysis | ChEMBL. | 27089209 |
IC50 (binding) | = 22 uM | Displacement of [3H]-Kainate from rat brain cortical membrane Ionotropic glutamate receptor kainate | ChEMBL. | 9357535 |
IC50 (binding) | = 22 uM | Displacement of [3H]-Kainate from rat brain cortical membrane Ionotropic glutamate receptor kainate | ChEMBL. | 9357535 |
IC50 (binding) | = 38 uM | Binding affinity in rat brain cortical membranes by the displacement of [3H]-AMPA at Ionotropic glutamate receptor AMPA | ChEMBL. | 9357535 |
IC50 (binding) | = 38 uM | Binding affinity in rat brain cortical membranes by the displacement of [3H]-AMPA at Ionotropic glutamate receptor AMPA | ChEMBL. | 9357535 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.