Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Bacteroides fragilis | Beta-lactamase type II | Starlite/ChEMBL | References |
Escherichia coli | Beta-lactamase TEM | Starlite/ChEMBL | References |
Escherichia coli | penicillin-binding protein | Starlite/ChEMBL | References |
Enterobacter cloacae | IMI-1 | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Mycobacterium ulcerans | class a beta-lactamase, BlaC | Get druggable targets OG5_143180 | All targets in OG5_143180 |
Mycobacterium tuberculosis | Class a beta-lactamase BlaC | Get druggable targets OG5_143180 | All targets in OG5_143180 |
Mycobacterium tuberculosis | Possible penicillin-binding protein | Get druggable targets OG5_149948 | All targets in OG5_149948 |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Onchocerca volvulus | Beta-lactamase type II | 249 aa | 253 aa | 20.6 % | |
Mycobacterium tuberculosis | Nicotinic acid phosphoribosyltransferase PncB2 | Beta-lactamase type II | 249 aa | 214 aa | 19.6 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Leishmania major | hypothetical protein, conserved | 0.0043 | 0.0147 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0043 | 0.0147 | 1 |
Plasmodium vivax | hypothetical protein, conserved | 0.0043 | 0.0147 | 1 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0043 | 0.0147 | 1 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0043 | 0.0147 | 0.5 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0043 | 0.0147 | 0.5 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0043 | 0.0147 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0043 | 0.0147 | 1 |
Loa Loa (eye worm) | beta-LACTamase domain containing family member | 0.0043 | 0.0147 | 1 |
Brugia malayi | beta-lactamase family protein | 0.0043 | 0.0147 | 1 |
Trichomonas vaginalis | penicillin-binding protein, putative | 0.0043 | 0.0147 | 0.5 |
Onchocerca volvulus | 0.0043 | 0.0147 | 1 | |
Brugia malayi | Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative | 0.0043 | 0.0147 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0043 | 0.0147 | 1 |
Onchocerca volvulus | 0.0043 | 0.0147 | 1 | |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0043 | 0.0147 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0043 | 0.0147 | 1 |
Echinococcus multilocularis | beta LACTamase domain containing family member | 0.0043 | 0.0147 | 1 |
Loa Loa (eye worm) | beta-lactamase | 0.0043 | 0.0147 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0043 | 0.0147 | 1 |
Mycobacterium tuberculosis | Possible penicillin-binding protein | 0.0278 | 0.848 | 0.8457 |
Mycobacterium tuberculosis | Probable conserved lipoprotein LpqF | 0.0154 | 0.4073 | 0.3984 |
Mycobacterium ulcerans | lipoprotein LpqF | 0.0154 | 0.4073 | 0.3984 |
Trypanosoma brucei | beta lactamase | 0.0154 | 0.4073 | 1 |
Trichomonas vaginalis | penicillin-binding protein, putative | 0.0043 | 0.0147 | 0.5 |
Brugia malayi | beta-lactamase family protein | 0.0043 | 0.0147 | 1 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0043 | 0.0147 | 1 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0043 | 0.0147 | 1 |
Toxoplasma gondii | ABC1 family protein | 0.0043 | 0.0147 | 1 |
Echinococcus granulosus | beta LACTamase domain containing family member | 0.0043 | 0.0147 | 1 |
Mycobacterium ulcerans | class a beta-lactamase, BlaC | 0.0321 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0043 | 0.0147 | 1 |
Brugia malayi | beta-lactamase | 0.0043 | 0.0147 | 1 |
Trichomonas vaginalis | esterase, putative | 0.0043 | 0.0147 | 0.5 |
Plasmodium falciparum | cysteine repeat modular protein 1 | 0.0039 | 0 | 0.5 |
Onchocerca volvulus | 0.0043 | 0.0147 | 1 | |
Mycobacterium leprae | PROBABLE CONSERVED LIPOPROTEIN LPQF | 0.0154 | 0.4073 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 1 nM | In vitro inhibitory activity against Class A (TEM-1) beta-Lactamases | ChEMBL. | 15214794 |
IC50 (binding) | = 1 nM | In vitro inhibitory activity against Class A (TEM-1) beta-Lactamases | ChEMBL. | 15214794 |
IC50 (binding) | = 2 nM | In vitro inhibitory activity against Class C (Amp-C) beta-Lactamases | ChEMBL. | 15214794 |
IC50 (binding) | = 2 nM | In vitro inhibitory activity against Class C (Amp-C) beta-Lactamases | ChEMBL. | 15214794 |
IC50 (binding) | = 14 nM | In vitro inhibitory activity against Class B (CCRA) beta-Lactamases | ChEMBL. | 15214794 |
IC50 (binding) | = 14 nM | In vitro inhibitory activity against Class B (CCRA) beta-Lactamases | ChEMBL. | 15214794 |
IC50 (binding) | = 50 nM | In vitro inhibitory activity against Class A (Imi-1) beta-Lactamases | ChEMBL. | 15214794 |
IC50 (binding) | = 50 nM | In vitro inhibitory activity against Class A (Imi-1) beta-Lactamases | ChEMBL. | 15214794 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.