Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | protease, serine, 1 (trypsin 1) | Starlite/ChEMBL | References |
Homo sapiens | coagulation factor X | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Brugia malayi | Trypsin family protein | protease, serine, 1 (trypsin 1) | 247 aa | 287 aa | 21.6 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.0138 | 0.4474 | 0.4474 |
Loa Loa (eye worm) | hypothetical protein | 0.0259 | 0.9566 | 0.9559 |
Loa Loa (eye worm) | hypothetical protein | 0.009 | 0.243 | 0.23 |
Schistosoma mansoni | subfamily M12A unassigned peptidase (M12 family) | 0.027 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0117 | 0.357 | 0.346 |
Brugia malayi | Fibulin-1 precursor | 0.0098 | 0.2776 | 0.7666 |
Brugia malayi | Trypsin family protein | 0.0117 | 0.357 | 1 |
Onchocerca volvulus | 0.0106 | 0.3133 | 0.8716 | |
Onchocerca volvulus | 0.0117 | 0.357 | 1 | |
Toxoplasma gondii | calcium binding egf domain-containing protein | 0.0098 | 0.2776 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0098 | 0.2776 | 0.2652 |
Loa Loa (eye worm) | hypothetical protein | 0.0119 | 0.368 | 0.3572 |
Schistosoma mansoni | egf-like domain protein | 0.009 | 0.243 | 0.243 |
Loa Loa (eye worm) | AStacin protease | 0.0159 | 0.5325 | 0.5245 |
Toxoplasma gondii | calcium binding egf domain-containing protein | 0.0098 | 0.2776 | 0.5 |
Loa Loa (eye worm) | multiple epidermal growth factor-like domains 6 | 0.0098 | 0.2776 | 0.2652 |
Brugia malayi | Low-density lipoprotein receptor repeat class B containing protein | 0.009 | 0.243 | 0.6648 |
Loa Loa (eye worm) | hypothetical protein | 0.0117 | 0.357 | 0.346 |
Brugia malayi | Calcium binding EGF domain containing protein | 0.0098 | 0.2776 | 0.7666 |
Loa Loa (eye worm) | bone morphogenetic protein 1b | 0.027 | 1 | 1 |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.0117 | 0.357 | 0.357 |
Loa Loa (eye worm) | low-density lipoprotein receptor repeat class B containing protein | 0.009 | 0.243 | 0.23 |
Loa Loa (eye worm) | hypothetical protein | 0.009 | 0.243 | 0.23 |
Onchocerca volvulus | Arrow homolog | 0.009 | 0.243 | 0.6648 |
Echinococcus multilocularis | Tolloid protein 1 | 0.027 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Clearance (ADMET) | > 2 l hr-1 kg-1 | Clearance rate of the compound in rabbits | ChEMBL. | 10328312 |
Ki (binding) | = 5.8 nM | Binding affinity against Coagulation factor X in an enzyme inhibition assay. | ChEMBL. | 10328312 |
Ki (binding) | = 5.8 nM | Binding affinity against Coagulation factor X in an enzyme inhibition assay. | ChEMBL. | 10328312 |
Ki (binding) | = 98 nM | Binding affinity against trypsin in an enzyme inhibition assay. | ChEMBL. | 10328312 |
Ki (binding) | = 98 nM | Binding affinity against trypsin in an enzyme inhibition assay. | ChEMBL. | 10328312 |
T1/2 (ADMET) | < 1 hr | Half life value of the compound in rabbits | ChEMBL. | 10328312 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.