Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | prolyl endopeptidase | No references | |
Mus musculus | fibroblast activation protein | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Trypanosoma brucei | oligopeptidase b | prolyl endopeptidase | 710 aa | 630 aa | 27.0 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | prolyl oligopeptidase family protein | 0.0226 | 0.3882 | 1 |
Echinococcus granulosus | dipeptidyl aminopeptidaseprotein | 0.0226 | 0.3882 | 0.3759 |
Echinococcus multilocularis | dipeptidyl aminopeptidaseprotein | 0.0226 | 0.3882 | 0.3759 |
Leishmania major | dipeptidyl-peptidase 8-like serine peptidase, putative,serine peptidase, Clan SC, Family S9B | 0.0087 | 0.0198 | 0.0784 |
Schistosoma mansoni | family S28 unassigned peptidase (S28 family) | 0.0456 | 1 | 1 |
Toxoplasma gondii | prolyl endopeptidase | 0.0175 | 0.2526 | 1 |
Schistosoma mansoni | prolyl oligopeptidase (S09 family) | 0.0175 | 0.2526 | 0.2375 |
Brugia malayi | prolyl oligopeptidase family protein | 0.0175 | 0.2526 | 0.632 |
Echinococcus granulosus | prolyl endopeptidase | 0.0175 | 0.2526 | 0.2375 |
Mycobacterium tuberculosis | Probable protease II PtrBa [first part] (oligopeptidase B) | 0.0142 | 0.1647 | 1 |
Trypanosoma cruzi | prolyl endopeptidase | 0.0175 | 0.2526 | 1 |
Mycobacterium leprae | PROBABLE PROTEASE II PTRBB (OLIGOPEPTIDASE B) | 0.0079 | 0 | 0.5 |
Loa Loa (eye worm) | prolyl oligopeptidase | 0.0226 | 0.3882 | 1 |
Leishmania major | prolyl oligopeptidase, putative,serine peptidase clan SC, family S9A, putative | 0.0175 | 0.2526 | 1 |
Schistosoma mansoni | subfamily S9B unassigned peptidase (S09 family) | 0.0226 | 0.3882 | 0.3759 |
Trypanosoma cruzi | serine peptidase, Clan SC, Family S9B | 0.0087 | 0.0198 | 0.0784 |
Echinococcus multilocularis | prolyl endopeptidase | 0.0175 | 0.2526 | 0.2375 |
Trypanosoma cruzi | dipeptidyl-peptidase 8-like serine peptidase | 0.0087 | 0.0198 | 0.0784 |
Trypanosoma brucei | prolyl endopeptidase | 0.0175 | 0.2526 | 1 |
Echinococcus multilocularis | Lysosomal Pro X carboxypeptidase | 0.0456 | 1 | 1 |
Schistosoma mansoni | prolyl oligopeptidase (S09 family) | 0.0175 | 0.2526 | 0.2375 |
Trypanosoma brucei | serine peptidase, Clan SC, Family S9B | 0.0087 | 0.0198 | 0.0784 |
Trypanosoma brucei | Dipeptidyl-peptidase 8-like, putative | 0.0087 | 0.0198 | 0.0784 |
Onchocerca volvulus | Dipeptidyl peptidase family member 1 homolog | 0.0226 | 0.3882 | 1 |
Mycobacterium ulcerans | protease II (oligopeptidase B), PtrB | 0.0079 | 0 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 5300 nM | Enzymatic Assay | BINDINGDB. | No reference |
IC50 (binding) | = 9000 nM | Enzymatic Assay | BINDINGDB. | No reference |
IC50 (binding) | > 100000 nM | Enzymatic Assay | BINDINGDB. | No reference |
IC50 (binding) | > 100000 nM | Enzymatic Assay | BINDINGDB. | No reference |
IC50 (binding) | > 100000 nM | Enzymatic Assay | BINDINGDB. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.