Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | monoamine oxidase B | No references | |
Homo sapiens | monoamine oxidase A | No references |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Mycobacterium tuberculosis | Probable flavin-containing monoamine oxidase AofH (amine oxidase) (MAO) | Get druggable targets OG5_130722 | All targets in OG5_130722 |
Mycobacterium ulcerans | flavin-containing monoamine oxidase AofH | Get druggable targets OG5_130722 | All targets in OG5_130722 |
Mycobacterium ulcerans | flavin-containing monoamine oxidase AofH | Get druggable targets OG5_130722 | All targets in OG5_130722 |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Brugia malayi | amine oxidase, flavin-containing family protein | monoamine oxidase A | 527 aa | 474 aa | 22.4 % |
Brugia malayi | amine oxidase, flavin-containing family protein | monoamine oxidase B | 520 aa | 462 aa | 19.7 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Chlamydia trachomatis | protoporphyrinogen oxidase | 0.0067 | 0.083 | 0.5 |
Schistosoma mansoni | Lysine-specific histone demethylase 1 | 0.0133 | 0.1738 | 1 |
Trypanosoma cruzi | UDP-galactopyranose mutase | 0.0067 | 0.083 | 0.5 |
Mycobacterium leprae | PROBABLE PROTOPORPHYRINOGEN OXIDASE HEMY (PROTOPORPHYRINOGEN-IX OXIDASE) (PROTOPORPHYRINOGENASE) (PPO) | 0.0067 | 0.083 | 0.5 |
Plasmodium vivax | hypothetical protein, conserved | 0.0067 | 0.083 | 0.5 |
Plasmodium vivax | hypothetical protein, conserved | 0.0067 | 0.083 | 0.5 |
Echinococcus granulosus | lysine specific histone demethylase 1A | 0.0133 | 0.1738 | 1 |
Plasmodium vivax | protoporphyrinogen oxidase, putative | 0.0067 | 0.083 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0074 | 0.0926 | 0.3382 |
Leishmania major | UDP-galactopyranose mutase | 0.0067 | 0.083 | 0.5 |
Plasmodium falciparum | lysine-specific histone demethylase 1, putative | 0.0067 | 0.083 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.014 | 0.1834 | 0.6698 |
Plasmodium vivax | lysine-specific histone demethylase 1, putative | 0.0067 | 0.083 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0067 | 0.083 | 0.303 |
Brugia malayi | hypothetical protein | 0.0067 | 0.083 | 0.3122 |
Echinococcus multilocularis | 0.0067 | 0.083 | 0.4775 | |
Echinococcus multilocularis | lysine specific histone demethylase 1A | 0.0133 | 0.1738 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0133 | 0.1738 | 0.6346 |
Brugia malayi | amine oxidase, flavin-containing family protein | 0.0074 | 0.0926 | 0.3485 |
Onchocerca volvulus | CoRest homolog | 0.0206 | 0.2738 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.02 | 0.2658 | 0.9706 |
Brugia malayi | SWIRM domain containing protein | 0.014 | 0.1834 | 0.6901 |
Mycobacterium tuberculosis | Probable flavin-containing monoamine oxidase AofH (amine oxidase) (MAO) | 0.0667 | 0.9074 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0067 | 0.083 | 0.303 |
Trypanosoma cruzi | UDP-galactopyranose mutase | 0.0067 | 0.083 | 0.5 |
Echinococcus granulosus | lysine specific histone demethylase 1A | 0.0067 | 0.083 | 0.4775 |
Loa Loa (eye worm) | hypothetical protein | 0.0206 | 0.2738 | 1 |
Schistosoma mansoni | Protoporphyrinogen oxidase chloroplast/mitochondrial precursor | 0.0067 | 0.083 | 0.4775 |
Plasmodium falciparum | protoporphyrinogen oxidase | 0.0067 | 0.083 | 0.5 |
Toxoplasma gondii | histone lysine-specific demethylase LSD1/BHC110/KDMA1A | 0.0067 | 0.083 | 1 |
Mycobacterium ulcerans | flavin-containing monoamine oxidase AofH | 0.0734 | 1 | 1 |
Plasmodium falciparum | conserved Plasmodium protein, unknown function | 0.0067 | 0.083 | 0.5 |
Schistosoma mansoni | amine oxidase | 0.0067 | 0.083 | 0.4775 |
Echinococcus multilocularis | protoporphyrinogen oxidase | 0.0067 | 0.083 | 0.4775 |
Loa Loa (eye worm) | hypothetical protein | 0.0133 | 0.1738 | 0.6346 |
Toxoplasma gondii | histone lysine-specific demethylase | 0.0067 | 0.083 | 1 |
Brugia malayi | Myb-like DNA-binding domain containing protein | 0.02 | 0.2658 | 1 |
Schistosoma mansoni | amine oxidase | 0.0067 | 0.083 | 0.4775 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 1360 nM | Fluorescence-Based (Inhibitor)-Screening Assay | BINDINGDB. | No reference |
IC50 (binding) | = 5230 nM | Fluorescence-Based (Inhibitor)-Screening Assay | BINDINGDB. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.