Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | leucine rich repeat serine:threonine protein | 0.0072 | 0.2573 | 0.2573 |
Echinococcus granulosus | serine threonine protein kinase | 0.0124 | 0.4517 | 0.4517 |
Echinococcus multilocularis | myosin iiia | 0.0063 | 0.2255 | 0.2255 |
Brugia malayi | Protein kinase domain containing protein | 0.0071 | 0.2555 | 0.2555 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0124 | 0.4517 | 0.5886 |
Trichomonas vaginalis | STE family protein kinase | 0.0124 | 0.4517 | 1 |
Echinococcus multilocularis | serine threonine protein kinase | 0.0124 | 0.4517 | 0.4517 |
Echinococcus multilocularis | serine:threonine protein kinase 3 | 0.027 | 1 | 1 |
Trichomonas vaginalis | STE family protein kinase | 0.0063 | 0.2255 | 0.4991 |
Plasmodium vivax | serine/threonine-specific protein kinase, putative | 0.0124 | 0.4517 | 1 |
Onchocerca volvulus | 0.0003 | 0 | 0.5 | |
Loa Loa (eye worm) | STE/STE20/MST protein kinase | 0.027 | 1 | 1 |
Entamoeba histolytica | serine/threonine protein kinase STE20, putative | 0.0063 | 0.2255 | 0.4991 |
Trypanosoma cruzi | STE/STE20 serine/threonine-protein kinase, putative | 0.0063 | 0.2255 | 1 |
Echinococcus granulosus | serine:threonine protein kinase 3 | 0.027 | 1 | 1 |
Trypanosoma cruzi | STE/STE20 serine/threonine-protein kinase, putative | 0.0063 | 0.2255 | 1 |
Plasmodium falciparum | protein kinase, putative | 0.0124 | 0.4517 | 1 |
Giardia lamblia | Kinase, STE STE20 | 0.0063 | 0.2255 | 0.5 |
Entamoeba histolytica | protein kinase, putative | 0.0124 | 0.4517 | 1 |
Schistosoma mansoni | ste20-related kinase | 0.0208 | 0.7674 | 1 |
Loa Loa (eye worm) | TKL/LRRK protein kinase | 0.0071 | 0.2555 | 0.2555 |
Trypanosoma brucei | STE20-like serine/threonine-protein kinase 1, putative | 0.0063 | 0.2255 | 1 |
Trichomonas vaginalis | STE family protein kinase | 0.0124 | 0.4517 | 1 |
Echinococcus multilocularis | leucine rich repeat serine:threonine protein | 0.0071 | 0.2555 | 0.2555 |
Entamoeba histolytica | serine/threonine-protein kinase 3, putative | 0.0063 | 0.2255 | 0.4991 |
Onchocerca volvulus | Mitochondrial Rho GTPase homolog | 0.0003 | 0 | 0.5 |
Loa Loa (eye worm) | STE/STE20/YSK protein kinase | 0.0124 | 0.4517 | 0.4517 |
Leishmania major | protein kinase, putative | 0.0063 | 0.2255 | 1 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.