Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | cyclin B2 | Starlite/ChEMBL | References |
Homo sapiens | cyclin B3 | Starlite/ChEMBL | References |
Homo sapiens | cyclin A1 | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | cyclins | 0.0064 | 0.0327 | 0.0919 |
Brugia malayi | Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog | 0.0082 | 0.0757 | 0.0757 |
Plasmodium falciparum | cyclin | 0.0064 | 0.0327 | 0.5 |
Echinococcus multilocularis | cyclins | 0.0064 | 0.0327 | 0.0919 |
Schistosoma mansoni | cyclin B | 0.0124 | 0.1768 | 0.4972 |
Echinococcus granulosus | cyclins | 0.0064 | 0.0327 | 0.0919 |
Entamoeba histolytica | cyclin, putative | 0.0124 | 0.1768 | 1 |
Trypanosoma brucei | mitotic cyclin 6 | 0.0124 | 0.1768 | 0.5 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0089 | 0.0917 | 0.258 |
Echinococcus granulosus | sodium channel protein | 0.0154 | 0.2495 | 0.7015 |
Trypanosoma cruzi | cyclin, putative | 0.0124 | 0.1768 | 0.5 |
Trichomonas vaginalis | cyclin B, putative | 0.0124 | 0.1768 | 1 |
Trichomonas vaginalis | cyclin B, putative | 0.0124 | 0.1768 | 1 |
Echinococcus multilocularis | cyclins | 0.0064 | 0.0327 | 0.0919 |
Echinococcus multilocularis | sodium channel protein | 0.0154 | 0.2495 | 0.7015 |
Onchocerca volvulus | 0.0124 | 0.1768 | 1 | |
Trichomonas vaginalis | cyclins, putative | 0.0075 | 0.0596 | 0.1865 |
Trichomonas vaginalis | cyclins, putative | 0.0124 | 0.1768 | 1 |
Echinococcus multilocularis | cyclins | 0.0064 | 0.0327 | 0.0919 |
Echinococcus granulosus | cyclins | 0.0064 | 0.0327 | 0.0919 |
Echinococcus multilocularis | potassium voltage gated channel subfamily H | 0.0082 | 0.0757 | 0.213 |
Echinococcus multilocularis | cyclin B | 0.0124 | 0.1768 | 0.4972 |
Echinococcus granulosus | potassium voltage gated channel subfamily H | 0.0082 | 0.0757 | 0.213 |
Echinococcus multilocularis | cyclin b3 | 0.0064 | 0.0327 | 0.0919 |
Loa Loa (eye worm) | hypothetical protein | 0.006 | 0.0223 | 0.0223 |
Trichomonas vaginalis | voltage and ligand gated potassium channel, putative | 0.0068 | 0.041 | 0.0576 |
Trypanosoma cruzi | cyclin, putative | 0.0124 | 0.1768 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0124 | 0.1768 | 0.1768 |
Trichomonas vaginalis | cyclin B, putative | 0.0124 | 0.1768 | 1 |
Trypanosoma cruzi | CYC2-like cyclin, putative | 0.0124 | 0.1768 | 0.5 |
Echinococcus granulosus | cyclin B3 1 | 0.0064 | 0.0327 | 0.0919 |
Brugia malayi | Cyclin, N-terminal domain containing protein | 0.0124 | 0.1768 | 0.1768 |
Brugia malayi | Cyclin, N-terminal domain containing protein | 0.0124 | 0.1768 | 0.1768 |
Echinococcus multilocularis | cyclins | 0.0064 | 0.0327 | 0.0919 |
Brugia malayi | Cyclin, N-terminal domain containing protein | 0.0199 | 0.3556 | 0.3556 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0089 | 0.0917 | 0.258 |
Trypanosoma cruzi | cyclin 6, putative | 0.0124 | 0.1768 | 0.5 |
Schistosoma mansoni | cyclins | 0.0064 | 0.0327 | 0.0919 |
Echinococcus multilocularis | cyclins | 0.0064 | 0.0327 | 0.0919 |
Trichomonas vaginalis | cyclin A, putative | 0.0124 | 0.1768 | 1 |
Echinococcus granulosus | cyclins | 0.0064 | 0.0327 | 0.0919 |
Echinococcus multilocularis | cyclins | 0.0064 | 0.0327 | 0.0919 |
Trichomonas vaginalis | cyclins, putative | 0.0124 | 0.1768 | 1 |
Echinococcus multilocularis | cyclins | 0.0064 | 0.0327 | 0.0919 |
Loa Loa (eye worm) | hypothetical protein | 0.0073 | 0.0527 | 0.0527 |
Loa Loa (eye worm) | voltage and ligand gated potassium channel | 0.0082 | 0.0757 | 0.0757 |
Trichomonas vaginalis | voltage and ligand gated potassium channel, putative | 0.0068 | 0.041 | 0.0576 |
Trichomonas vaginalis | cyclins, putative | 0.0124 | 0.1768 | 1 |
Echinococcus granulosus | cyclin b3 | 0.0064 | 0.0327 | 0.0919 |
Leishmania major | calcium channel protein, putative,ion transporter, putative | 0.0154 | 0.2495 | 1 |
Trichomonas vaginalis | cyclins, putative | 0.0124 | 0.1768 | 1 |
Echinococcus granulosus | G2:mitotic specific cyclin B3 | 0.0199 | 0.3556 | 1 |
Echinococcus granulosus | voltage gated sodium channel Nav1 alpha subunit | 0.0154 | 0.2495 | 0.7015 |
Schistosoma mansoni | cyclin B3 | 0.0199 | 0.3556 | 1 |
Echinococcus multilocularis | G2:mitotic specific cyclin B3 | 0.0199 | 0.3556 | 1 |
Echinococcus granulosus | cyclins | 0.0064 | 0.0327 | 0.0919 |
Loa Loa (eye worm) | hypothetical protein | 0.0467 | 1 | 1 |
Loa Loa (eye worm) | cyclin domain-containing protein | 0.0199 | 0.3556 | 0.3556 |
Loa Loa (eye worm) | hypothetical protein | 0.0124 | 0.1768 | 0.1768 |
Brugia malayi | sulfakinin receptor protein | 0.0467 | 1 | 1 |
Giardia lamblia | G2/mitotic-specific cyclin B | 0.0124 | 0.1768 | 1 |
Echinococcus multilocularis | cyclin B3 1 | 0.0064 | 0.0327 | 0.0919 |
Echinococcus granulosus | cyclin B | 0.0124 | 0.1768 | 0.4972 |
Trichomonas vaginalis | cyclin B, putative | 0.0124 | 0.1768 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 0.21 uM | Inhibition of cyclin-dependent kinase 2-cyclin A3 (CDK2) | ChEMBL. | 15239650 |
IC50 (binding) | = 0.21 uM | Inhibition of cyclin-dependent kinase 2-cyclin A3 (CDK2) | ChEMBL. | 15239650 |
IC50 (binding) | = 0.24 uM | Inhibitory activity against cyclin-dependent kinase 1-cyclin B. | ChEMBL. | 15239650 |
IC50 (binding) | = 0.24 uM | Inhibitory activity against cyclin-dependent kinase 1-cyclin B. | ChEMBL. | 15239650 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.