Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Plasmodium falciparum | conserved Plasmodium protein, unknown function | 0.0067 | 0.083 | 0.5 |
Mycobacterium ulcerans | flavin-containing monoamine oxidase AofH | 0.0734 | 1 | 1 |
Toxoplasma gondii | histone lysine-specific demethylase LSD1/BHC110/KDMA1A | 0.0067 | 0.083 | 1 |
Plasmodium falciparum | protoporphyrinogen oxidase | 0.0067 | 0.083 | 0.5 |
Schistosoma mansoni | Protoporphyrinogen oxidase chloroplast/mitochondrial precursor | 0.0067 | 0.083 | 0.4775 |
Loa Loa (eye worm) | hypothetical protein | 0.0206 | 0.2738 | 1 |
Trypanosoma cruzi | UDP-galactopyranose mutase | 0.0067 | 0.083 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0067 | 0.083 | 0.303 |
Echinococcus granulosus | lysine specific histone demethylase 1A | 0.0067 | 0.083 | 0.4775 |
Brugia malayi | Myb-like DNA-binding domain containing protein | 0.02 | 0.2658 | 1 |
Schistosoma mansoni | amine oxidase | 0.0067 | 0.083 | 0.4775 |
Toxoplasma gondii | histone lysine-specific demethylase | 0.0067 | 0.083 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0133 | 0.1738 | 0.6346 |
Echinococcus multilocularis | protoporphyrinogen oxidase | 0.0067 | 0.083 | 0.4775 |
Schistosoma mansoni | amine oxidase | 0.0067 | 0.083 | 0.4775 |
Brugia malayi | amine oxidase, flavin-containing family protein | 0.0074 | 0.0926 | 0.3485 |
Loa Loa (eye worm) | hypothetical protein | 0.0133 | 0.1738 | 0.6346 |
Echinococcus multilocularis | lysine specific histone demethylase 1A | 0.0133 | 0.1738 | 1 |
Echinococcus multilocularis | 0.0067 | 0.083 | 0.4775 | |
Brugia malayi | hypothetical protein | 0.0067 | 0.083 | 0.3122 |
Mycobacterium tuberculosis | Probable flavin-containing monoamine oxidase AofH (amine oxidase) (MAO) | 0.0667 | 0.9074 | 1 |
Brugia malayi | SWIRM domain containing protein | 0.014 | 0.1834 | 0.6901 |
Loa Loa (eye worm) | hypothetical protein | 0.02 | 0.2658 | 0.9706 |
Onchocerca volvulus | CoRest homolog | 0.0206 | 0.2738 | 1 |
Plasmodium vivax | protoporphyrinogen oxidase, putative | 0.0067 | 0.083 | 0.5 |
Echinococcus granulosus | lysine specific histone demethylase 1A | 0.0133 | 0.1738 | 1 |
Plasmodium vivax | hypothetical protein, conserved | 0.0067 | 0.083 | 0.5 |
Plasmodium vivax | lysine-specific histone demethylase 1, putative | 0.0067 | 0.083 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0067 | 0.083 | 0.303 |
Loa Loa (eye worm) | hypothetical protein | 0.014 | 0.1834 | 0.6698 |
Plasmodium falciparum | lysine-specific histone demethylase 1, putative | 0.0067 | 0.083 | 0.5 |
Leishmania major | UDP-galactopyranose mutase | 0.0067 | 0.083 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0074 | 0.0926 | 0.3382 |
Trypanosoma cruzi | UDP-galactopyranose mutase | 0.0067 | 0.083 | 0.5 |
Schistosoma mansoni | Lysine-specific histone demethylase 1 | 0.0133 | 0.1738 | 1 |
Chlamydia trachomatis | protoporphyrinogen oxidase | 0.0067 | 0.083 | 0.5 |
Plasmodium vivax | hypothetical protein, conserved | 0.0067 | 0.083 | 0.5 |
Mycobacterium leprae | PROBABLE PROTOPORPHYRINOGEN OXIDASE HEMY (PROTOPORPHYRINOGEN-IX OXIDASE) (PROTOPORPHYRINOGENASE) (PPO) | 0.0067 | 0.083 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 100000 nM | Fluorescence-Based (Inhibitor)-Screening Assay | BINDINGDB. | No reference |
IC50 (binding) | > 100000 nM | Fluorescence-Based (Inhibitor)-Screening Assay | BINDINGDB. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.