Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | REST corepressor 1 | References | |
Homo sapiens | monoamine oxidase A | References | |
Homo sapiens | monoamine oxidase B | References |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | Get druggable targets OG5_141013 | All targets in OG5_141013 |
Mycobacterium ulcerans | flavin-containing monoamine oxidase AofH | Get druggable targets OG5_130722 | All targets in OG5_130722 |
Onchocerca volvulus | CoRest homolog | Get druggable targets OG5_141013 | All targets in OG5_141013 |
Mycobacterium ulcerans | flavin-containing monoamine oxidase AofH | Get druggable targets OG5_130722 | All targets in OG5_130722 |
Brugia malayi | Myb-like DNA-binding domain containing protein | Get druggable targets OG5_141013 | All targets in OG5_141013 |
Mycobacterium tuberculosis | Probable flavin-containing monoamine oxidase AofH (amine oxidase) (MAO) | Get druggable targets OG5_130722 | All targets in OG5_130722 |
Loa Loa (eye worm) | hypothetical protein | Get druggable targets OG5_141013 | All targets in OG5_141013 |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Brugia malayi | amine oxidase, flavin-containing family protein | monoamine oxidase B | 520 aa | 462 aa | 19.7 % |
Brugia malayi | amine oxidase, flavin-containing family protein | monoamine oxidase A | 527 aa | 474 aa | 22.4 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0051 | 0.0628 | 0.223 |
Trypanosoma cruzi | UDP-galactopyranose mutase | 0.0051 | 0.0628 | 0.5 |
Echinococcus granulosus | lysine specific histone demethylase 1A | 0.0051 | 0.0628 | 1 |
Brugia malayi | Myb-like DNA-binding domain containing protein | 0.02 | 0.2733 | 1 |
Trypanosoma cruzi | UDP-galactopyranose mutase | 0.0051 | 0.0628 | 0.5 |
Plasmodium falciparum | conserved Plasmodium protein, unknown function | 0.0051 | 0.0628 | 0.5 |
Onchocerca volvulus | CoRest homolog | 0.0206 | 0.2815 | 1 |
Plasmodium vivax | lysine-specific histone demethylase 1, putative | 0.0051 | 0.0628 | 0.5 |
Leishmania major | UDP-galactopyranose mutase | 0.0051 | 0.0628 | 0.5 |
Plasmodium falciparum | lysine-specific histone demethylase 1, putative | 0.0051 | 0.0628 | 0.5 |
Mycobacterium ulcerans | flavin-containing monoamine oxidase AofH | 0.0717 | 1 | 1 |
Schistosoma mansoni | amine oxidase | 0.0051 | 0.0628 | 1 |
Mycobacterium tuberculosis | Probable flavin-containing monoamine oxidase AofH (amine oxidase) (MAO) | 0.0667 | 0.929 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0051 | 0.0628 | 0.223 |
Loa Loa (eye worm) | hypothetical protein | 0.02 | 0.2733 | 0.9708 |
Loa Loa (eye worm) | hypothetical protein | 0.0206 | 0.2815 | 1 |
Echinococcus multilocularis | lysine specific histone demethylase 1A | 0.0051 | 0.0628 | 1 |
Plasmodium vivax | hypothetical protein, conserved | 0.0051 | 0.0628 | 0.5 |
Plasmodium vivax | hypothetical protein, conserved | 0.0051 | 0.0628 | 0.5 |
Echinococcus multilocularis | 0.0051 | 0.0628 | 1 | |
Loa Loa (eye worm) | hypothetical protein | 0.0051 | 0.0628 | 0.223 |
Toxoplasma gondii | histone lysine-specific demethylase LSD1/BHC110/KDMA1A | 0.0051 | 0.0628 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0051 | 0.0628 | 0.223 |
Schistosoma mansoni | amine oxidase | 0.0051 | 0.0628 | 1 |
Echinococcus multilocularis | protoporphyrinogen oxidase | 0.0051 | 0.0628 | 1 |
Chlamydia trachomatis | protoporphyrinogen oxidase | 0.0051 | 0.0628 | 0.5 |
Mycobacterium leprae | PROBABLE PROTOPORPHYRINOGEN OXIDASE HEMY (PROTOPORPHYRINOGEN-IX OXIDASE) (PROTOPORPHYRINOGENASE) (PPO) | 0.0051 | 0.0628 | 0.5 |
Toxoplasma gondii | histone lysine-specific demethylase | 0.0051 | 0.0628 | 0.5 |
Schistosoma mansoni | Lysine-specific histone demethylase 1 | 0.0051 | 0.0628 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0051 | 0.0628 | 0.223 |
Schistosoma mansoni | Protoporphyrinogen oxidase chloroplast/mitochondrial precursor | 0.0051 | 0.0628 | 1 |
Plasmodium falciparum | protoporphyrinogen oxidase | 0.0051 | 0.0628 | 0.5 |
Echinococcus granulosus | lysine specific histone demethylase 1A | 0.0051 | 0.0628 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0051 | 0.0628 | 0.223 |
Plasmodium vivax | protoporphyrinogen oxidase, putative | 0.0051 | 0.0628 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 0.0548 uM | Inhibition of human recombinant MAOA expressed in Pichia pastoris preincubated for 15 mins measured after 30 mins by bioluminescent-coupled assay | ChEMBL. | 26702542 |
IC50 (binding) | = 0.0615 uM | Inhibition of human recombinant KDM1A/CoREST expressed in Escherichia coli using mono-methylated H3-K4 peptide as substrate assessed as H2O2 release preincubated for 15 mins followed by substrate addition measured for 12 mins by fluorescence-based microplate reader analysis | ChEMBL. | 26702542 |
IC50 (binding) | = 0.6 uM | Inhibition of human recombinant MAOB expressed in Pichia pastoris preincubated for 15 mins measured after 30 mins by bioluminescent-coupled assay | ChEMBL. | 26702542 |
IC50 (binding) | = 74.7 uM | Inhibition of KDM1B (unknown origin) | ChEMBL. | 26702542 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.