Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | cyclin B2 | Starlite/ChEMBL | References |
Homo sapiens | cyclin B3 | Starlite/ChEMBL | References |
Homo sapiens | cyclin A1 | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | G2:mitotic specific cyclin B3 | 0.0199 | 1 | 1 |
Trichomonas vaginalis | cyclin B, putative | 0.0124 | 0.4636 | 1 |
Trichomonas vaginalis | cyclins, putative | 0.0124 | 0.4636 | 1 |
Trichomonas vaginalis | cyclin A, putative | 0.0124 | 0.4636 | 1 |
Onchocerca volvulus | 0.0124 | 0.4636 | 0.5 | |
Schistosoma mansoni | cyclin B | 0.0124 | 0.4636 | 0.4463 |
Trypanosoma cruzi | CYC2-like cyclin, putative | 0.0124 | 0.4636 | 0.5 |
Trichomonas vaginalis | cyclin B, putative | 0.0124 | 0.4636 | 1 |
Trichomonas vaginalis | cyclin B, putative | 0.0124 | 0.4636 | 1 |
Plasmodium falciparum | cyclin | 0.0064 | 0.0312 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0124 | 0.4636 | 0.4636 |
Trypanosoma brucei | mitotic cyclin 6 | 0.0124 | 0.4636 | 0.5 |
Trichomonas vaginalis | cyclin B, putative | 0.0124 | 0.4636 | 1 |
Trypanosoma cruzi | cyclin 6, putative | 0.0124 | 0.4636 | 0.5 |
Echinococcus granulosus | cyclin B | 0.0124 | 0.4636 | 0.4463 |
Trichomonas vaginalis | cyclins, putative | 0.0124 | 0.4636 | 1 |
Trypanosoma cruzi | cyclin, putative | 0.0124 | 0.4636 | 0.5 |
Loa Loa (eye worm) | cyclin domain-containing protein | 0.0199 | 1 | 1 |
Trichomonas vaginalis | cyclins, putative | 0.0124 | 0.4636 | 1 |
Trichomonas vaginalis | cyclins, putative | 0.0075 | 0.1119 | 0.1865 |
Trichomonas vaginalis | cyclins, putative | 0.0124 | 0.4636 | 1 |
Trypanosoma cruzi | cyclin, putative | 0.0124 | 0.4636 | 0.5 |
Schistosoma mansoni | cyclin B3 | 0.0199 | 1 | 1 |
Echinococcus multilocularis | cyclin B | 0.0124 | 0.4636 | 0.4463 |
Leishmania major | cyclin | 0.0124 | 0.4636 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0124 | 0.4636 | 0.4636 |
Echinococcus granulosus | G2:mitotic specific cyclin B3 | 0.0199 | 1 | 1 |
Leishmania major | CYC2-like cyclin, putative,cyclin 6, putative | 0.0124 | 0.4636 | 0.5 |
Giardia lamblia | G2/mitotic-specific cyclin B | 0.0124 | 0.4636 | 1 |
Entamoeba histolytica | cyclin, putative | 0.0124 | 0.4636 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 2.8 uM | Inhibition of cyclin-dependent kinase 2-cyclin A3 (CDK2) | ChEMBL. | 15239650 |
IC50 (binding) | = 2.8 uM | Inhibition of cyclin-dependent kinase 2-cyclin A3 (CDK2) | ChEMBL. | 15239650 |
IC50 (binding) | = 3.2 uM | Inhibitory activity against cyclin-dependent kinase 1-cyclin B. | ChEMBL. | 15239650 |
IC50 (binding) | = 3.2 uM | Inhibitory activity against cyclin-dependent kinase 1-cyclin B. | ChEMBL. | 15239650 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.